Ke Xie
@kexie.bsky.social
PhD candidate @MICA Lab (https://mica-mni.github.io/index.html) @McGill University @Montreal Neurological Institute
epilepsy | neuroimaging | connectomics
epilepsy | neuroimaging | connectomics
5️⃣ Toward precision medicine in epilepsy!
✅ Using these individual deviation maps, machine learning models achieved precise diagnosis, seizure onset zone lateralization, and prediction of postsurgical seizure outcome. 💊 📃
✅ Using these individual deviation maps, machine learning models achieved precise diagnosis, seizure onset zone lateralization, and prediction of postsurgical seizure outcome. 💊 📃
April 27, 2025 at 7:48 AM
5️⃣ Toward precision medicine in epilepsy!
✅ Using these individual deviation maps, machine learning models achieved precise diagnosis, seizure onset zone lateralization, and prediction of postsurgical seizure outcome. 💊 📃
✅ Using these individual deviation maps, machine learning models achieved precise diagnosis, seizure onset zone lateralization, and prediction of postsurgical seizure outcome. 💊 📃
4️⃣ Superficial white matter (SWM) anomalies emerge as a key driver. 🧠
🎯 SWM microstructure disruption primarily underpins cortical functional alterations in TLE.
🎯 SWM microstructure disruption primarily underpins cortical functional alterations in TLE.
April 27, 2025 at 7:48 AM
4️⃣ Superficial white matter (SWM) anomalies emerge as a key driver. 🧠
🎯 SWM microstructure disruption primarily underpins cortical functional alterations in TLE.
🎯 SWM microstructure disruption primarily underpins cortical functional alterations in TLE.
3️⃣ The brain’s structural connectome acts as a scaffold!
🧩 Functional alteration patterns are strongly shaped by the white matter network architecture.
🧩 Functional alteration patterns are strongly shaped by the white matter network architecture.
April 27, 2025 at 7:48 AM
3️⃣ The brain’s structural connectome acts as a scaffold!
🧩 Functional alteration patterns are strongly shaped by the white matter network architecture.
🧩 Functional alteration patterns are strongly shaped by the white matter network architecture.
2️⃣ TLE patients show substantial heterogeneity in cortical alteration patterns.
📊 The greatest overlap is in the temporolimbic cortex, but no two patients are exactly the same.
📊 The greatest overlap is in the temporolimbic cortex, but no two patients are exactly the same.
April 27, 2025 at 7:48 AM
2️⃣ TLE patients show substantial heterogeneity in cortical alteration patterns.
📊 The greatest overlap is in the temporolimbic cortex, but no two patients are exactly the same.
📊 The greatest overlap is in the temporolimbic cortex, but no two patients are exactly the same.
1️⃣ We computed individualized brain functional deviations at local, regional, and global levels.
📈 Highlighted brain regions with extreme deviations — for every single TLE patient.
📈 Highlighted brain regions with extreme deviations — for every single TLE patient.
April 27, 2025 at 7:48 AM
1️⃣ We computed individualized brain functional deviations at local, regional, and global levels.
📈 Highlighted brain regions with extreme deviations — for every single TLE patient.
📈 Highlighted brain regions with extreme deviations — for every single TLE patient.
(5/5) Out-of-sample replication
Findings are robustly replicated in the UNAM #TLE cohort, demonstrating strong generalizability and reliability.
Findings are robustly replicated in the UNAM #TLE cohort, demonstrating strong generalizability and reliability.
January 15, 2025 at 1:55 AM
(5/5) Out-of-sample replication
Findings are robustly replicated in the UNAM #TLE cohort, demonstrating strong generalizability and reliability.
Findings are robustly replicated in the UNAM #TLE cohort, demonstrating strong generalizability and reliability.
(3/5) Connectome constraints on local E/I imbalance
Regions structurally and functionally connected to atypical clusters are more vulnerable, facilitating disease spread. Temporal and frontal cortices emerge as potential disease epicenters.
Regions structurally and functionally connected to atypical clusters are more vulnerable, facilitating disease spread. Temporal and frontal cortices emerge as potential disease epicenters.
January 15, 2025 at 1:53 AM
(3/5) Connectome constraints on local E/I imbalance
Regions structurally and functionally connected to atypical clusters are more vulnerable, facilitating disease spread. Temporal and frontal cortices emerge as potential disease epicenters.
Regions structurally and functionally connected to atypical clusters are more vulnerable, facilitating disease spread. Temporal and frontal cortices emerge as potential disease epicenters.
