Kesavardan S
LightNews LightNews
banner
keshu-vrimmch.bsky.social
Kesavardan S
@keshu-vrimmch.bsky.social
60 followers 27 following 20 posts
Asst Professor at #Biochemistry, Indian Institute of Science #IISc.
Interested in Zoonotic & H5Nx viruses, Bats/Birds, Z-RNAs, Inflammasomes & Cell death.
Posts Replies Media Videos
keshu-vrimmch.bsky.social
www.biorxiv.org/content/10.1...
Avian influenza virus neuraminidase stalk length and haemagglutinin glycosylation patterns reveal molecularly directed reassortment promoting the emergence of highly pathogenic clade 2.3.4.4b A (H5N1)...
The recently emerged panzootic clade 2.3.4.4b H5N1 influenza viruses show unprecedented extensive spread in wild birds and have been transmitted to several mammals, including humans. The virologic fac...
www.biorxiv.org
March 3, 2025 at 10:54 AM
keshu-vrimmch.bsky.social
Our observations led us to establish and validate the hypothesis that the pairing of #avian #influenza virus HA and NA subtypes is not stochastic but is rather molecularly regulated by HA glycosylation and NA stalk length.
March 3, 2025 at 10:52 AM
keshu-vrimmch.bsky.social
We identified the emergence of 2.3.4.4b H5 HA with a distinct #glycosylation pattern in its #RBD that drove its preferential pairing with #longStalk N1 and the emergence of this novel variant.
March 3, 2025 at 10:52 AM
keshu-vrimmch.bsky.social
#Gs/GD lineage #H5 successfully paired with a variety of NAs (N2, N5, N6 & N8). But the emergence of long stalk N1 led to the dominance of #H5N1 of 2.3.4.4b clade. Why did this particular clade need a long stalk, unlike the previous clades having short stalk N1?
March 3, 2025 at 10:51 AM
keshu-vrimmch.bsky.social
Thanks.!
February 22, 2025 at 1:12 PM