Great work from our PhD student @gaonskim and huge thanks to the rest of the team @BramshQ @Sebastian1Ben @wendyfyx @PTenigma We hope this work helps the field towards more precise, reproducible white matter mapping in autism.

Read the preprint 👉 biorxiv.org/content/10.1... (5/5)

These tracts connected frontal, parietal, temporal, and occipital regions—suggesting that white matter microstructure differences in autism may be greater within specific regions of individual tracts, and that the implicated tracts are distributed across the brain. (4/5)

We analyzed dMRI data from 365 participants (ages 5–24, 34% female) across 10 cohorts. Our findings?
🧠 Autism was linked to lower FA and higher diffusivity
📍 But not uniformly—alterations were localized to specific subregions of commissural & association tracts (3/5)

Prior dMRI studies in autism have found inconsistent results across tracts—partly due to limitations in conventional analysis methods. We took a different approach:
✅BUAN (along-tract analytics)
✅TDF (advanced microstructure modeling)
= sharper, more reliable insights (2/5)

ENIGMA Autism is always accepting new sites. If you have neuroimaging data from autistic participants and are interested in joining or learning more, just reach out!

It'd be great if I could be added, thank you!

Hope you've been doing well Arielle! I'd like to be added please, thank you.