Keith Matthews
@keithrmatthews.bsky.social
Professor of Parasite Biology at the University of Edinburgh. #Trypanosomes, #parasites, #infections, #UniversityofEdinburgh
https://biology.ed.ac.uk/the-matthews-lab
https://biology.ed.ac.uk/the-matthews-lab
We have a 3+ year post doc available in our lab to study trypanosome transmission and virulence. Combined wet lab and bioinformatics expertise preferred. Please apply via the HR link (elxw.fa.em3.oraclecloud.com/hcmUI/Candid...). Find out more about us in the link below.
The Matthews Lab | Biology
The Matthews Lab
biology.ed.ac.uk
October 17, 2025 at 12:06 PM
We have a 3+ year post doc available in our lab to study trypanosome transmission and virulence. Combined wet lab and bioinformatics expertise preferred. Please apply via the HR link (elxw.fa.em3.oraclecloud.com/hcmUI/Candid...). Find out more about us in the link below.
Please consider applying for a post doc in our lab if you have bioinformatics and wet lab skills, and are interested in parasites!
elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
Postdoctoral Research Associate
This project will seek to understand the basis of increased virulence after long term coinfection by a combination of genomic, transcriptomic and laboratory manipulation of the selected parasite lines...
elxw.fa.em3.oraclecloud.com
May 16, 2025 at 10:48 AM
Please consider applying for a post doc in our lab if you have bioinformatics and wet lab skills, and are interested in parasites!
elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
Exploring the chromatin proteome of Trypanosoma brucei repetitive elements (telomeres, centromeres, 70bp repeats, 177bp repeats) using TALEs. Another great collaboration with @allshire-lab.bsky.social
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Defining the chromatin-associated protein landscapes on Trypanosoma brucei repetitive elements using synthetic TALE proteins
Kinetoplastids, such as Trypansoma brucei, are eukaryotes that likely separated from the main lineage at an exceptionally early point in evolution. Consequently, many aspects of kinetoplastid biology ...
www.biorxiv.org
April 24, 2025 at 8:30 AM
Exploring the chromatin proteome of Trypanosoma brucei repetitive elements (telomeres, centromeres, 70bp repeats, 177bp repeats) using TALEs. Another great collaboration with @allshire-lab.bsky.social
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Reposted by Keith Matthews
I'm very pleased to have two lab positions open this week, to join our team looking at immune regulation in infection and co-infection. We're especially interested in tissue-based immunity, cytokine regulation and immune metabolism. Join us! Postdoc (3y) and research technician (12mo) posts open.
March 3, 2025 at 8:46 AM
I'm very pleased to have two lab positions open this week, to join our team looking at immune regulation in infection and co-infection. We're especially interested in tissue-based immunity, cytokine regulation and immune metabolism. Join us! Postdoc (3y) and research technician (12mo) posts open.
We've previously looked at the developmental biology of trypanosome infections in mice, but parastaemias are unnaturally high in mice compared to cattle. Read what happens in cattle when blood parasitaemias are low and so quorum sensing may be limited...
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Trypanosoma brucei cattle infections contain cryptic transmission-adapted bloodstream forms at low parasitaemia
Tsetse-transmitted Trypanosoma parasites infect a wide host range and cause Human African Trypanosomiasis and Animal African Trypanosomosis in sub-Saharan Africa. The primary hosts of Trypanosoma bruc...
www.biorxiv.org
February 24, 2025 at 9:28 AM
We've previously looked at the developmental biology of trypanosome infections in mice, but parastaemias are unnaturally high in mice compared to cattle. Read what happens in cattle when blood parasitaemias are low and so quorum sensing may be limited...
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Keith Matthews
Really interesting day discussing impacts of climate change on vector borne diseases workshop today. Lots of great science and discussion about exciting projects to take forwards. @keithrmatthews.bsky.social #reecelab @roslininstitute.bsky.social @amypedersen.bsky.social
February 7, 2025 at 3:28 PM
Really interesting day discussing impacts of climate change on vector borne diseases workshop today. Lots of great science and discussion about exciting projects to take forwards. @keithrmatthews.bsky.social #reecelab @roslininstitute.bsky.social @amypedersen.bsky.social
Having played a small part in a manuscript to be published in the journal 'Bioinformatics' I was interested to read the inaugural article about the journal from founding editor Rob Beynon in 1985. Worth a read (I hope OA) to see how things move on.
academic.oup.com/bioinformati...
academic.oup.com/bioinformati...
CABIOS EDITORIAL
R.J. Beynon; CABIOS EDITORIAL, Bioinformatics, Volume 1, Issue 1, 1 January 1985, Pages 1, https://doi.org/10.1093/bioinformatics/1.1.1
academic.oup.com
January 30, 2025 at 9:53 AM
Having played a small part in a manuscript to be published in the journal 'Bioinformatics' I was interested to read the inaugural article about the journal from founding editor Rob Beynon in 1985. Worth a read (I hope OA) to see how things move on.
academic.oup.com/bioinformati...
academic.oup.com/bioinformati...
Reposted by Keith Matthews
As the world marks Neglected Tropical Diseases Day, researchers from @edinburgh-uni.bsky.social are collaborating with the #RoyalSocietyofEdinburgh and #UnitingtoCombatNeglectedTropicalDiseases to host a free, public exhibition 31 Jan - 4 Feb. Get tickets now!
www.eventbrite.co.uk/e/amplifying...
www.eventbrite.co.uk/e/amplifying...
Amplifying affected voices: neglected tropical diseases | Free exhibition
A powerful exhibition to mark World Neglected Tropical Disease Day.
www.eventbrite.co.uk
January 20, 2025 at 9:32 AM
As the world marks Neglected Tropical Diseases Day, researchers from @edinburgh-uni.bsky.social are collaborating with the #RoyalSocietyofEdinburgh and #UnitingtoCombatNeglectedTropicalDiseases to host a free, public exhibition 31 Jan - 4 Feb. Get tickets now!
www.eventbrite.co.uk/e/amplifying...
www.eventbrite.co.uk/e/amplifying...
Breakfast with colleagues at a conference when you’ve just received mixed reviews on your latest paper
January 16, 2025 at 7:28 PM
Breakfast with colleagues at a conference when you’ve just received mixed reviews on your latest paper
The Institute kindly provided us with a new board to display our papers. Only a selection, but each one of them brought back such strong memories of the people involved, their effort, the setbacks, the battles with referees and final celebration. Important not to forget the stories behind any paper!
January 16, 2025 at 3:29 PM
The Institute kindly provided us with a new board to display our papers. Only a selection, but each one of them brought back such strong memories of the people involved, their effort, the setbacks, the battles with referees and final celebration. Important not to forget the stories behind any paper!
I’ve been enjoying the Apple Intelligence summaries of iMessages. But it gave me a fright when we were planning a trip to my mother-in-law’s and not sure whether to take some lunch as she hadn’t phoned to confirm. The AI message from my wife flashed up as “mum unresponsive, not taking food”
January 13, 2025 at 8:42 PM
I’ve been enjoying the Apple Intelligence summaries of iMessages. But it gave me a fright when we were planning a trip to my mother-in-law’s and not sure whether to take some lunch as she hadn’t phoned to confirm. The AI message from my wife flashed up as “mum unresponsive, not taking food”
How SPPIRIT is transforming early career profiles in Parasitology in Scotland
www.cell.com/action/showP...
www.cell.com/action/showP...
www.cell.com
January 8, 2025 at 4:03 PM
How SPPIRIT is transforming early career profiles in Parasitology in Scotland
www.cell.com/action/showP...
www.cell.com/action/showP...
Reposted by Keith Matthews
Many thanks to the @siegel-lab.bsky.social, to our collaborators @allshire-lab.bsky.social and @keithrmatthews.bsky.social,and to the funding agencies that supported this project.
December 24, 2024 at 12:11 PM
Many thanks to the @siegel-lab.bsky.social, to our collaborators @allshire-lab.bsky.social and @keithrmatthews.bsky.social,and to the funding agencies that supported this project.
Congratulations to all at the Siegel group - Christmas comes (a little) early!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Inter-chromosomal transcription hubs shape the 3D genome architecture of African trypanosomes - Nature Communications
Decoding the role of inter-chromosomal DNA-DNA interactions remains challenging. Here, the authors use Micro-C to study the T. brucei genome architecture at high resolution and reveal an intricate net...
www.nature.com
December 24, 2024 at 8:23 AM
Congratulations to all at the Siegel group - Christmas comes (a little) early!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Keith Matthews
Genes linked to deadly parasites’ spread beyond Africa identified.
Parasites that cause the deadly illness known as sleeping sickness can spread beyond their native Africa as a result of mutations to key genes.
@keithrmatthews.bsky.social
@goldrieve.bsky.social
Full article: shorturl.at/9jlGS
Parasites that cause the deadly illness known as sleeping sickness can spread beyond their native Africa as a result of mutations to key genes.
@keithrmatthews.bsky.social
@goldrieve.bsky.social
Full article: shorturl.at/9jlGS
December 19, 2024 at 10:49 AM
Genes linked to deadly parasites’ spread beyond Africa identified.
Parasites that cause the deadly illness known as sleeping sickness can spread beyond their native Africa as a result of mutations to key genes.
@keithrmatthews.bsky.social
@goldrieve.bsky.social
Full article: shorturl.at/9jlGS
Parasites that cause the deadly illness known as sleeping sickness can spread beyond their native Africa as a result of mutations to key genes.
@keithrmatthews.bsky.social
@goldrieve.bsky.social
Full article: shorturl.at/9jlGS
Reposted by Keith Matthews
Excited to share our work on life cycle simplification (monomorphism) in Trypanosoma brucei in Nature Comms @natureportfolio.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Mechanisms of life cycle simplification in African trypanosomes - Nature Communications
African trypanosomes can reduce their requirement for tsetse fly transmission, allowing an expanded geographical range. Here, molecular analyses of field and laboratory selected lines has identified a...
www.nature.com
December 2, 2024 at 4:32 PM
Excited to share our work on life cycle simplification (monomorphism) in Trypanosoma brucei in Nature Comms @natureportfolio.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
What good way to start with Bluesky!
Delighted to share our paper on how non-tsetse transmitted trypanosomes lose the ability to make stumpy forms (and adapt to the monomorphic life style) and so can spread outside Africa. A great reward after years of hard work from Guy Oldrieve !
rdcu.be/d13YK
Delighted to share our paper on how non-tsetse transmitted trypanosomes lose the ability to make stumpy forms (and adapt to the monomorphic life style) and so can spread outside Africa. A great reward after years of hard work from Guy Oldrieve !
rdcu.be/d13YK
Mechanisms of life cycle simplification in African trypanosomes
Nature Communications - African trypanosomes can reduce their requirement for tsetse fly transmission, allowing an expanded geographical range. Here, molecular analyses of field and laboratory...
rdcu.be
December 2, 2024 at 3:53 PM
What good way to start with Bluesky!
Delighted to share our paper on how non-tsetse transmitted trypanosomes lose the ability to make stumpy forms (and adapt to the monomorphic life style) and so can spread outside Africa. A great reward after years of hard work from Guy Oldrieve !
rdcu.be/d13YK
Delighted to share our paper on how non-tsetse transmitted trypanosomes lose the ability to make stumpy forms (and adapt to the monomorphic life style) and so can spread outside Africa. A great reward after years of hard work from Guy Oldrieve !
rdcu.be/d13YK
Reposted by Keith Matthews
Here’s my spreadsheet of starter packs (>80!) related to broadly ‘mechanistic biology’ plus some intriguing extras
Complete with collective nouns
I’ve been tracking these but now can’t keep up
Hope it’s helpful
2/2
docs.google.com/spreadsheets...
Complete with collective nouns
I’ve been tracking these but now can’t keep up
Hope it’s helpful
2/2
docs.google.com/spreadsheets...
@mjafreeman.bsky.social's BlueSky starter packs for 'mechanistic' biologists
docs.google.com
November 19, 2024 at 9:58 PM
Here’s my spreadsheet of starter packs (>80!) related to broadly ‘mechanistic biology’ plus some intriguing extras
Complete with collective nouns
I’ve been tracking these but now can’t keep up
Hope it’s helpful
2/2
docs.google.com/spreadsheets...
Complete with collective nouns
I’ve been tracking these but now can’t keep up
Hope it’s helpful
2/2
docs.google.com/spreadsheets...