Kevin Debatisse
@kdebatisse.bsky.social
Postdoctoral researcher - Institut Pasteur - Team "Bacterial Genome Plasticity" - Mazel's Lab -Molecular microbiology - HGT - MGE - DNA recombination.
Mechanistically, incoming ssDNA is a game changer: it promotes attC site folding, triggers integrase expression via SOS, and allows cassette excision without the need for replicative resolution. This suggests both intra- and inter-bacterial shuffling shape integron recombination dynamics. 4/5
November 17, 2025 at 3:44 PM
Mechanistically, incoming ssDNA is a game changer: it promotes attC site folding, triggers integrase expression via SOS, and allows cassette excision without the need for replicative resolution. This suggests both intra- and inter-bacterial shuffling shape integron recombination dynamics. 4/5
Integrons are genetic “biobanks” that bacteria use to adapt on demand. They store cassettes that provide functions from antibiotic resistance to phage defense. Our lab showed that cassette shuffling in SCIs is limited because toxin–antitoxin cassettes keep cassette excision rate low. 2/5
November 17, 2025 at 3:44 PM
Integrons are genetic “biobanks” that bacteria use to adapt on demand. They store cassettes that provide functions from antibiotic resistance to phage defense. Our lab showed that cassette shuffling in SCIs is limited because toxin–antitoxin cassettes keep cassette excision rate low. 2/5
Integrons are genetic “biobanks” that bacteria use to adapt on demand. They store cassettes that provide functions from antibiotic resistance to phage defense. Our lab showed that cassette shuffling in SCIs is limited because toxin–antitoxin cassettes keep cassette excision rate low. 2/5
November 17, 2025 at 3:34 PM
Integrons are genetic “biobanks” that bacteria use to adapt on demand. They store cassettes that provide functions from antibiotic resistance to phage defense. Our lab showed that cassette shuffling in SCIs is limited because toxin–antitoxin cassettes keep cassette excision rate low. 2/5