Katrin Böttcher
@kboettcherlab.bsky.social
physician scientist 👩🏻⚕️🔬
aims at understanding #MAIT cell biology in #tissueimmunity and #cancer
passionate about #immunometabolism
based at M3 Research Center at University of Tübingen
aims at understanding #MAIT cell biology in #tissueimmunity and #cancer
passionate about #immunometabolism
based at M3 Research Center at University of Tübingen
9/ 📖 Read more: www.journal-of-hepatology.eu/article/S016...
@easlnews.bsky.social @jhepatology.bsky.social @cd1mr1.bsky.social
#Immunometabolism #MAITcells #LiverImmunology #Ferroptosis #MASLD #HCC #LipidPeroxidation #TcellDysfunction #CancerImmunotherapy #TumorMicroenvironment #FattyLiver
@easlnews.bsky.social @jhepatology.bsky.social @cd1mr1.bsky.social
#Immunometabolism #MAITcells #LiverImmunology #Ferroptosis #MASLD #HCC #LipidPeroxidation #TcellDysfunction #CancerImmunotherapy #TumorMicroenvironment #FattyLiver
Polyunsaturated fatty acid-induced metabolic exhaustion and ferroptosis impair the anti-tumour function of MAIT cells in MASLD
Mucosal-associated invariant T (MAIT) cells constitute a highly abundant innate-like
T cell population in the human liver that is critical for immune surveillance of hepatic
cancers but often dysfunct...
www.journal-of-hepatology.eu
June 23, 2025 at 7:51 AM
8/ 🙏 Grateful to an outstanding team of collaborators and co-authors for their input to our project. @knollelab.bsky.social @jboettcherlab.bsky.social and all others that are not on social media
June 23, 2025 at 7:51 AM
8/ 🙏 Grateful to an outstanding team of collaborators and co-authors for their input to our project. @knollelab.bsky.social @jboettcherlab.bsky.social and all others that are not on social media
7/ 🏥 Clinical implications:
The PUFA–lipid peroxide axis we have identified represents a targetable metabolic checkpoint to enhance immunotherapy in HCC.
The PUFA–lipid peroxide axis we have identified represents a targetable metabolic checkpoint to enhance immunotherapy in HCC.
June 23, 2025 at 7:51 AM
7/ 🏥 Clinical implications:
The PUFA–lipid peroxide axis we have identified represents a targetable metabolic checkpoint to enhance immunotherapy in HCC.
The PUFA–lipid peroxide axis we have identified represents a targetable metabolic checkpoint to enhance immunotherapy in HCC.
6/ 💡 Conclusion:
MASLD generates a lipid-driven immunosuppressive microenvironment by inducing metabolic exhaustion-mediated dysfunction and ferroptosis in MAIT cells - an abundant intrahepatic T cell subset with anti-tumour properties.
MASLD generates a lipid-driven immunosuppressive microenvironment by inducing metabolic exhaustion-mediated dysfunction and ferroptosis in MAIT cells - an abundant intrahepatic T cell subset with anti-tumour properties.
June 23, 2025 at 7:51 AM
6/ 💡 Conclusion:
MASLD generates a lipid-driven immunosuppressive microenvironment by inducing metabolic exhaustion-mediated dysfunction and ferroptosis in MAIT cells - an abundant intrahepatic T cell subset with anti-tumour properties.
MASLD generates a lipid-driven immunosuppressive microenvironment by inducing metabolic exhaustion-mediated dysfunction and ferroptosis in MAIT cells - an abundant intrahepatic T cell subset with anti-tumour properties.
5/
• Interfering with lipid peroxide formation reverses MAIT dysfunction and restores anti-cancer activity.
• A PUFA-MAIT cell gene signature correlates with poor overall survival of patients with HCC.
• Interfering with lipid peroxide formation reverses MAIT dysfunction and restores anti-cancer activity.
• A PUFA-MAIT cell gene signature correlates with poor overall survival of patients with HCC.
June 23, 2025 at 7:51 AM
5/
• Interfering with lipid peroxide formation reverses MAIT dysfunction and restores anti-cancer activity.
• A PUFA-MAIT cell gene signature correlates with poor overall survival of patients with HCC.
• Interfering with lipid peroxide formation reverses MAIT dysfunction and restores anti-cancer activity.
• A PUFA-MAIT cell gene signature correlates with poor overall survival of patients with HCC.
4/
• PUFAs induce intracellular lipid peroxidation, driving metabolic exhaustion – i.e. mitochondrial and glycolytic dysfunction – and triggering ferroptosis.
• PUFAs induce intracellular lipid peroxidation, driving metabolic exhaustion – i.e. mitochondrial and glycolytic dysfunction – and triggering ferroptosis.
June 23, 2025 at 7:51 AM
4/
• PUFAs induce intracellular lipid peroxidation, driving metabolic exhaustion – i.e. mitochondrial and glycolytic dysfunction – and triggering ferroptosis.
• PUFAs induce intracellular lipid peroxidation, driving metabolic exhaustion – i.e. mitochondrial and glycolytic dysfunction – and triggering ferroptosis.
3/ 🔬Core findings:
• In MASLD, MAIT cells exhibit profound functional exhaustion, including impaired cytokine production and anti-tumour activity.
• Mechanistically, PUFAs accumulate selectively in MAIT cells, not in conventional CD8⁺ or NK cells.
• In MASLD, MAIT cells exhibit profound functional exhaustion, including impaired cytokine production and anti-tumour activity.
• Mechanistically, PUFAs accumulate selectively in MAIT cells, not in conventional CD8⁺ or NK cells.
June 23, 2025 at 7:51 AM
3/ 🔬Core findings:
• In MASLD, MAIT cells exhibit profound functional exhaustion, including impaired cytokine production and anti-tumour activity.
• Mechanistically, PUFAs accumulate selectively in MAIT cells, not in conventional CD8⁺ or NK cells.
• In MASLD, MAIT cells exhibit profound functional exhaustion, including impaired cytokine production and anti-tumour activity.
• Mechanistically, PUFAs accumulate selectively in MAIT cells, not in conventional CD8⁺ or NK cells.
2/ In our study, we identify a previously unrecognised immunometabolic axis that links polyunsaturated fatty acids (PUFAs) to MAIT cell dysfunction in patients with MASLD.
June 23, 2025 at 7:51 AM
2/ In our study, we identify a previously unrecognised immunometabolic axis that links polyunsaturated fatty acids (PUFAs) to MAIT cell dysfunction in patients with MASLD.
1/ Our latest findings provide a possible mechanism on why patients with MASLD (metabolic dysfunction-associated steatotic liver disease) are more vulnerable to liver cancer.
June 23, 2025 at 7:51 AM
1/ Our latest findings provide a possible mechanism on why patients with MASLD (metabolic dysfunction-associated steatotic liver disease) are more vulnerable to liver cancer.
7/ 💡 Clinical implications:
Targeting the PUFA–lipid peroxide axis represents a targetable metabolic checkpoint to enhance immunotherapy in HCC.
Targeting the PUFA–lipid peroxide axis represents a targetable metabolic checkpoint to enhance immunotherapy in HCC.
June 23, 2025 at 7:42 AM
7/ 💡 Clinical implications:
Targeting the PUFA–lipid peroxide axis represents a targetable metabolic checkpoint to enhance immunotherapy in HCC.
Targeting the PUFA–lipid peroxide axis represents a targetable metabolic checkpoint to enhance immunotherapy in HCC.
6/ 🧠 Conclusion:
MASLD generates a lipid-driven immunosuppressive microenvironment by inducing metabolic exhaustion-mediated dysfunction and ferroptosis in MAIT cells—an abundant intrahepatic T cell subset with anti-tumour properties.
MASLD generates a lipid-driven immunosuppressive microenvironment by inducing metabolic exhaustion-mediated dysfunction and ferroptosis in MAIT cells—an abundant intrahepatic T cell subset with anti-tumour properties.
June 23, 2025 at 7:42 AM
6/ 🧠 Conclusion:
MASLD generates a lipid-driven immunosuppressive microenvironment by inducing metabolic exhaustion-mediated dysfunction and ferroptosis in MAIT cells—an abundant intrahepatic T cell subset with anti-tumour properties.
MASLD generates a lipid-driven immunosuppressive microenvironment by inducing metabolic exhaustion-mediated dysfunction and ferroptosis in MAIT cells—an abundant intrahepatic T cell subset with anti-tumour properties.
5/
• Interfering with lipid peroxide formation reverses MAIT dysfunction and restores anti-cancer activity.
• A PUFA-MAIT cell gene signature correlates with poor overall survival of patients with HCC.
• Interfering with lipid peroxide formation reverses MAIT dysfunction and restores anti-cancer activity.
• A PUFA-MAIT cell gene signature correlates with poor overall survival of patients with HCC.
June 23, 2025 at 7:42 AM
5/
• Interfering with lipid peroxide formation reverses MAIT dysfunction and restores anti-cancer activity.
• A PUFA-MAIT cell gene signature correlates with poor overall survival of patients with HCC.
• Interfering with lipid peroxide formation reverses MAIT dysfunction and restores anti-cancer activity.
• A PUFA-MAIT cell gene signature correlates with poor overall survival of patients with HCC.
4/
• PUFAs induce intracellular lipid peroxidation, driving metabolic exhaustion – mitochondrial and glycolytic dysfunction – and triggering ferroptosis.
• PUFAs induce intracellular lipid peroxidation, driving metabolic exhaustion – mitochondrial and glycolytic dysfunction – and triggering ferroptosis.
June 23, 2025 at 7:42 AM
4/
• PUFAs induce intracellular lipid peroxidation, driving metabolic exhaustion – mitochondrial and glycolytic dysfunction – and triggering ferroptosis.
• PUFAs induce intracellular lipid peroxidation, driving metabolic exhaustion – mitochondrial and glycolytic dysfunction – and triggering ferroptosis.
3/ 🔬Core findings:
• In MASLD, MAIT cells exhibit profound functional exhaustion, including impaired cytokine production and anti-tumor activity.
• Mechanistically, PUFAs accumulate selectively in MAIT cells, not in conventional CD8⁺ or NK cells.
• In MASLD, MAIT cells exhibit profound functional exhaustion, including impaired cytokine production and anti-tumor activity.
• Mechanistically, PUFAs accumulate selectively in MAIT cells, not in conventional CD8⁺ or NK cells.
June 23, 2025 at 7:42 AM
3/ 🔬Core findings:
• In MASLD, MAIT cells exhibit profound functional exhaustion, including impaired cytokine production and anti-tumor activity.
• Mechanistically, PUFAs accumulate selectively in MAIT cells, not in conventional CD8⁺ or NK cells.
• In MASLD, MAIT cells exhibit profound functional exhaustion, including impaired cytokine production and anti-tumor activity.
• Mechanistically, PUFAs accumulate selectively in MAIT cells, not in conventional CD8⁺ or NK cells.
2/ In our study, we identify a previously unrecognized immunometabolic axis that links polyunsaturated fatty acids (PUFAs) to MAIT cell dysfunction in patients with MASLD.
June 23, 2025 at 7:42 AM
2/ In our study, we identify a previously unrecognized immunometabolic axis that links polyunsaturated fatty acids (PUFAs) to MAIT cell dysfunction in patients with MASLD.
1/ Our latest findings provide a possible mechanism on why patients with MASLD (metabolic dysfunction-associated steatotic liver disease) are more vulnerable to liver cancer.
June 23, 2025 at 7:42 AM
1/ Our latest findings provide a possible mechanism on why patients with MASLD (metabolic dysfunction-associated steatotic liver disease) are more vulnerable to liver cancer.
8/ 🙏 Grateful to an outstanding team of collaborators and co-authors for their input to our project. @knollelab.bsky.social @jboettcherlab.bsky.social
June 23, 2025 at 7:35 AM
8/ 🙏 Grateful to an outstanding team of collaborators and co-authors for their input to our project. @knollelab.bsky.social @jboettcherlab.bsky.social
7/ 💡 Clinical implications:
Targeting the PUFA–lipid peroxide axis represents a targetable metabolic checkpoint to enhance immunotherapy in HCC.
Targeting the PUFA–lipid peroxide axis represents a targetable metabolic checkpoint to enhance immunotherapy in HCC.
June 23, 2025 at 7:35 AM
7/ 💡 Clinical implications:
Targeting the PUFA–lipid peroxide axis represents a targetable metabolic checkpoint to enhance immunotherapy in HCC.
Targeting the PUFA–lipid peroxide axis represents a targetable metabolic checkpoint to enhance immunotherapy in HCC.
6/ 🧠 Conclusion:
MASLD generates a lipid-driven immunosuppressive microenvironment by inducing metabolic exhaustion-mediated dysfunction and ferroptosis in MAIT cells—an abundant intrahepatic T cell subset with anti-tumour properties.
MASLD generates a lipid-driven immunosuppressive microenvironment by inducing metabolic exhaustion-mediated dysfunction and ferroptosis in MAIT cells—an abundant intrahepatic T cell subset with anti-tumour properties.
June 23, 2025 at 7:35 AM
6/ 🧠 Conclusion:
MASLD generates a lipid-driven immunosuppressive microenvironment by inducing metabolic exhaustion-mediated dysfunction and ferroptosis in MAIT cells—an abundant intrahepatic T cell subset with anti-tumour properties.
MASLD generates a lipid-driven immunosuppressive microenvironment by inducing metabolic exhaustion-mediated dysfunction and ferroptosis in MAIT cells—an abundant intrahepatic T cell subset with anti-tumour properties.
5/
• Interfering with lipid peroxide formation reverses MAIT dysfunction and restores anti-cancer activity.
• A PUFA-MAIT cell gene signature correlates with poor overall survival of patients with HCC.
• Interfering with lipid peroxide formation reverses MAIT dysfunction and restores anti-cancer activity.
• A PUFA-MAIT cell gene signature correlates with poor overall survival of patients with HCC.
June 23, 2025 at 7:35 AM
5/
• Interfering with lipid peroxide formation reverses MAIT dysfunction and restores anti-cancer activity.
• A PUFA-MAIT cell gene signature correlates with poor overall survival of patients with HCC.
• Interfering with lipid peroxide formation reverses MAIT dysfunction and restores anti-cancer activity.
• A PUFA-MAIT cell gene signature correlates with poor overall survival of patients with HCC.
4/
• PUFAs induce intracellular lipid peroxidation, driving metabolic exhaustion – mitochondrial and glycolytic dysfunction – and triggering ferroptosis.
• PUFAs induce intracellular lipid peroxidation, driving metabolic exhaustion – mitochondrial and glycolytic dysfunction – and triggering ferroptosis.
June 23, 2025 at 7:35 AM
4/
• PUFAs induce intracellular lipid peroxidation, driving metabolic exhaustion – mitochondrial and glycolytic dysfunction – and triggering ferroptosis.
• PUFAs induce intracellular lipid peroxidation, driving metabolic exhaustion – mitochondrial and glycolytic dysfunction – and triggering ferroptosis.
3/ 🔬Core findings:
• In MASLD, MAIT cells exhibit profound functional exhaustion, including impaired cytokine production and anti-tumour activity.
• Mechanistically, PUFAs accumulate selectively in MAIT cells, not in conventional CD8⁺ or NK cells.
• In MASLD, MAIT cells exhibit profound functional exhaustion, including impaired cytokine production and anti-tumour activity.
• Mechanistically, PUFAs accumulate selectively in MAIT cells, not in conventional CD8⁺ or NK cells.
June 23, 2025 at 7:35 AM
3/ 🔬Core findings:
• In MASLD, MAIT cells exhibit profound functional exhaustion, including impaired cytokine production and anti-tumour activity.
• Mechanistically, PUFAs accumulate selectively in MAIT cells, not in conventional CD8⁺ or NK cells.
• In MASLD, MAIT cells exhibit profound functional exhaustion, including impaired cytokine production and anti-tumour activity.
• Mechanistically, PUFAs accumulate selectively in MAIT cells, not in conventional CD8⁺ or NK cells.
2/ In our study, we identify a previously unrecognised immunometabolic axis that links polyunsaturated fatty acids (PUFAs) to MAIT cell dysfunction in patients with MASLD.
June 23, 2025 at 7:35 AM
2/ In our study, we identify a previously unrecognised immunometabolic axis that links polyunsaturated fatty acids (PUFAs) to MAIT cell dysfunction in patients with MASLD.