Leon Kaulen
@kaulenleon.bsky.social
Neurologist @uniklinik_hd | Clinician Scientist @HdNeurooncology @DKFZ, @MGHNeuroOnc | Interested in CNS lymphomas and development of personalized therapies
🚨Excited to share 📝 on TIAN in CNS lymphoma after CD19 CAR T. Key findings: 1) TIAN occurs early after CAR (median 3.5d). 2) Larger baseline tumor volume is a risk factor. 3) TIAN correlates with improved ORR/PFS 4) Autopsy findings support localized on-tumor, on-target neurotox, distinct from ICANS
July 21, 2025 at 10:56 AM
🚨Excited to share 📝 on TIAN in CNS lymphoma after CD19 CAR T. Key findings: 1) TIAN occurs early after CAR (median 3.5d). 2) Larger baseline tumor volume is a risk factor. 3) TIAN correlates with improved ORR/PFS 4) Autopsy findings support localized on-tumor, on-target neurotox, distinct from ICANS