David Katz
@katzlab.bsky.social
The Katz Lab at Emory University School of Medicine studies transgenerational epigenetics and the role of epigenetics in Alzheimer’s Disease using C. elegans and mouse
If the same thing is true in the corresponding human patients, might it be possible to revert cognitive/behavior deficits in the human patients also?
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media.tenor.com
October 7, 2025 at 2:43 PM
If the same thing is true in the corresponding human patients, might it be possible to revert cognitive/behavior deficits in the human patients also?
So, expressing germline genes in neurons can block their function in a way that is reversible if you shut off the inappropriate transcription
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October 7, 2025 at 2:43 PM
So, expressing germline genes in neurons can block their function in a way that is reversible if you shut off the inappropriate transcription
Turning off the ectopic germline gene expression in the neurons of worms that already have a chemotaxis behavior defect, reverses the behavior back to normal
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October 7, 2025 at 2:43 PM
Turning off the ectopic germline gene expression in the neurons of worms that already have a chemotaxis behavior defect, reverses the behavior back to normal
So, could the chemotaxis behavior defect be due to an ongoing defect in an intact nervous system? If so, might it be possible to reverse the chemotaxis behavior defect even after the nervous system has fully formed?
October 7, 2025 at 2:43 PM
So, could the chemotaxis behavior defect be due to an ongoing defect in an intact nervous system? If so, might it be possible to reverse the chemotaxis behavior defect even after the nervous system has fully formed?
And an intact nervous system
October 7, 2025 at 2:43 PM
And an intact nervous system
No changes in the embryonic lineage
October 7, 2025 at 2:43 PM
No changes in the embryonic lineage
Progeny of spr-5 (lsd1) and met-2 (setdb1) double mutants have germline genes expressed in somatic cells, which causes a severe chemotaxis behavior defect, but surprise...
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October 7, 2025 at 2:43 PM
Progeny of spr-5 (lsd1) and met-2 (setdb1) double mutants have germline genes expressed in somatic cells, which causes a severe chemotaxis behavior defect, but surprise...
The invariant C. elegans lineage and adult nervous system provide the perfect opportunity to find out how every cell responds to inappropriately inherited chromatin and altered transcription
October 7, 2025 at 2:43 PM
The invariant C. elegans lineage and adult nervous system provide the perfect opportunity to find out how every cell responds to inappropriately inherited chromatin and altered transcription
Ever wonder how something as broad as a chromatin mutant causes cell specific phenotypes?
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media.tenor.com
October 7, 2025 at 2:43 PM
Ever wonder how something as broad as a chromatin mutant causes cell specific phenotypes?
Really cool. Looking forward to reading it. The Peters’ lab publishes amazing science.
September 12, 2025 at 10:34 AM
Really cool. Looking forward to reading it. The Peters’ lab publishes amazing science.
A lot of important views expressed here. I am just curious how the potential to flood the zone with fake papers feeds into all of this?
September 9, 2025 at 12:12 PM
A lot of important views expressed here. I am just curious how the potential to flood the zone with fake papers feeds into all of this?