Katja Kobow
@katjakobow.bsky.social
Epigenetics enthusiast. Working in molecular neuropathology 🧠🔬🧬 @FAU.de. Visiting scientist @UKL_Leipzig. Malformations and #epilepsy. DNA methylation and #aging.
kobowlab.org
kobowlab.org
q.e.d. is a game changer. Thank you. Great to see the partnering with biorxiv!
November 6, 2025 at 7:58 PM
q.e.d. is a game changer. Thank you. Great to see the partnering with biorxiv!
Fantastic work led by PhD student Erica Cecchini and bright Neuropathology resident Lucas Hoffmann! Congratulations 🎊 @ebmresearch.bsky.social
October 20, 2025 at 8:30 AM
Fantastic work led by PhD student Erica Cecchini and bright Neuropathology resident Lucas Hoffmann! Congratulations 🎊 @ebmresearch.bsky.social
PCR for the Y-chromosome-specific SRY locus from microdissected areas in surgical 🧠 tissue confirms lesion-specific Y-chromosome gains in female MOGHE patients in the white matter, but not cortex
October 20, 2025 at 8:30 AM
PCR for the Y-chromosome-specific SRY locus from microdissected areas in surgical 🧠 tissue confirms lesion-specific Y-chromosome gains in female MOGHE patients in the white matter, but not cortex
FISH analysis on surgical 🧠 samples with probes mapping to sex chromosomes confirms Y-chromosome gains in both sexes
October 20, 2025 at 8:30 AM
FISH analysis on surgical 🧠 samples with probes mapping to sex chromosomes confirms Y-chromosome gains in both sexes
Copy number analysis based on brain-derived DNA Methylation signatures shows Y-chromosome gains in males and females
October 20, 2025 at 8:30 AM
Copy number analysis based on brain-derived DNA Methylation signatures shows Y-chromosome gains in males and females
Take-home message:
Epilepsy and aging intersect at the molecular level.
Recognizing accelerated epigenetic aging as part of epileptogenesis may reshape how we understand, and eventually treat, epilepsy.
Epilepsy and aging intersect at the molecular level.
Recognizing accelerated epigenetic aging as part of epileptogenesis may reshape how we understand, and eventually treat, epilepsy.
October 8, 2025 at 10:18 AM
Take-home message:
Epilepsy and aging intersect at the molecular level.
Recognizing accelerated epigenetic aging as part of epileptogenesis may reshape how we understand, and eventually treat, epilepsy.
Epilepsy and aging intersect at the molecular level.
Recognizing accelerated epigenetic aging as part of epileptogenesis may reshape how we understand, and eventually treat, epilepsy.
Why it’s important:
These results identify biological aging as a mechanistic feature of epilepsy, opening new perspectives for intervention and disease modification possibly through targeting aging pathways.
These results identify biological aging as a mechanistic feature of epilepsy, opening new perspectives for intervention and disease modification possibly through targeting aging pathways.
October 8, 2025 at 10:18 AM
Why it’s important:
These results identify biological aging as a mechanistic feature of epilepsy, opening new perspectives for intervention and disease modification possibly through targeting aging pathways.
These results identify biological aging as a mechanistic feature of epilepsy, opening new perspectives for intervention and disease modification possibly through targeting aging pathways.
In mice:
Findings were confirmed. Moreover, accelerated aging in some animals appeared before seizures developed, indicating it is not merely a consequence of epilepsy, but part of the epileptogenic process itself.
Findings were confirmed. Moreover, accelerated aging in some animals appeared before seizures developed, indicating it is not merely a consequence of epilepsy, but part of the epileptogenic process itself.
October 8, 2025 at 10:18 AM
In mice:
Findings were confirmed. Moreover, accelerated aging in some animals appeared before seizures developed, indicating it is not merely a consequence of epilepsy, but part of the epileptogenic process itself.
Findings were confirmed. Moreover, accelerated aging in some animals appeared before seizures developed, indicating it is not merely a consequence of epilepsy, but part of the epileptogenic process itself.
What we found:
🧠 Epileptic brain tissue showed accelerated biological aging compared to non-epileptic autopsy controls.
🩸 Blood samples revealed similar patterns, across different etiologies.
🧬 The brain aged faster than the blood.
🧠 Epileptic brain tissue showed accelerated biological aging compared to non-epileptic autopsy controls.
🩸 Blood samples revealed similar patterns, across different etiologies.
🧬 The brain aged faster than the blood.
October 8, 2025 at 10:18 AM
What we found:
🧠 Epileptic brain tissue showed accelerated biological aging compared to non-epileptic autopsy controls.
🩸 Blood samples revealed similar patterns, across different etiologies.
🧬 The brain aged faster than the blood.
🧠 Epileptic brain tissue showed accelerated biological aging compared to non-epileptic autopsy controls.
🩸 Blood samples revealed similar patterns, across different etiologies.
🧬 The brain aged faster than the blood.
What we did:
We analyzed DNA methylation from surgical brain and blood samples of 298 epilepsy patients (structural and genetic forms) and compared them to controls.
We also studied an mTOR mouse model of epilepsy.
We analyzed DNA methylation from surgical brain and blood samples of 298 epilepsy patients (structural and genetic forms) and compared them to controls.
We also studied an mTOR mouse model of epilepsy.
October 8, 2025 at 10:18 AM
What we did:
We analyzed DNA methylation from surgical brain and blood samples of 298 epilepsy patients (structural and genetic forms) and compared them to controls.
We also studied an mTOR mouse model of epilepsy.
We analyzed DNA methylation from surgical brain and blood samples of 298 epilepsy patients (structural and genetic forms) and compared them to controls.
We also studied an mTOR mouse model of epilepsy.
The question:
Is accelerated biological aging measured by “epigenetic clocks” involved in epilepsy? While these clocks have linked aging to cancer, cardiovascular, and neurodegenerative diseases, their role in epilepsy was unknown.
Is accelerated biological aging measured by “epigenetic clocks” involved in epilepsy? While these clocks have linked aging to cancer, cardiovascular, and neurodegenerative diseases, their role in epilepsy was unknown.
October 8, 2025 at 10:18 AM
The question:
Is accelerated biological aging measured by “epigenetic clocks” involved in epilepsy? While these clocks have linked aging to cancer, cardiovascular, and neurodegenerative diseases, their role in epilepsy was unknown.
Is accelerated biological aging measured by “epigenetic clocks” involved in epilepsy? While these clocks have linked aging to cancer, cardiovascular, and neurodegenerative diseases, their role in epilepsy was unknown.
Why it matters: People with epilepsy have a 10-12 years reduced life expectancy and an increased burden of age-related comorbidities. Seizures trigger molecular and cellular hallmarks of aging, yet direct evidence for accelerated aging in epilepsy has been lacking.
October 8, 2025 at 10:18 AM
Why it matters: People with epilepsy have a 10-12 years reduced life expectancy and an increased burden of age-related comorbidities. Seizures trigger molecular and cellular hallmarks of aging, yet direct evidence for accelerated aging in epilepsy has been lacking.