Kate Adamala
@kateadamala.bsky.social
Life as we don't know it: building biology from scratch with synthetic cells.
http://www.protobiology.org/
http://www.protobiology.org/
Stay tuned :) We're about to post on archive a protocol that will solve the problem. The precious Roche stocks will be replaced by warm fresh homemade tRNAs.
March 25, 2025 at 7:47 PM
Stay tuned :) We're about to post on archive a protocol that will solve the problem. The precious Roche stocks will be replaced by warm fresh homemade tRNAs.
Unfortunately yes.
We need to engineer new pathway, either with a racemase or starting with achiral precursors.
We need to engineer new pathway, either with a racemase or starting with achiral precursors.
December 14, 2024 at 6:00 PM
Unfortunately yes.
We need to engineer new pathway, either with a racemase or starting with achiral precursors.
We need to engineer new pathway, either with a racemase or starting with achiral precursors.
Yes.
I'm hoping the attention will help with making plans.
I'm hoping the attention will help with making plans.
December 14, 2024 at 5:29 PM
Yes.
I'm hoping the attention will help with making plans.
I'm hoping the attention will help with making plans.
Me too. That's why this whole thing in the first place. I hope common sense (in short supply recently) will actually prevail.
December 14, 2024 at 5:27 PM
Me too. That's why this whole thing in the first place. I hope common sense (in short supply recently) will actually prevail.
Antimatter life would at least be useful. Make a planet into nice fireworks.
December 14, 2024 at 3:03 PM
Antimatter life would at least be useful. Make a planet into nice fireworks.
The cheerful holiday thought here is that people who worked on mirror life recognized the concerns and will now work against it ever being built.
The timing is nice, that's a Christmas present for all of us.
The timing is nice, that's a Christmas present for all of us.
December 14, 2024 at 3:01 PM
The cheerful holiday thought here is that people who worked on mirror life recognized the concerns and will now work against it ever being built.
The timing is nice, that's a Christmas present for all of us.
The timing is nice, that's a Christmas present for all of us.
They would likely not be resistant to mirror antibiotics.
Still should not be made.
Still should not be made.
December 14, 2024 at 2:59 PM
They would likely not be resistant to mirror antibiotics.
Still should not be made.
Still should not be made.
That's kind of the point though, we will _not_ make it.
We're determined to leave wiping of us to the climate and other already existing threats, without adding a new one.
We're determined to leave wiping of us to the climate and other already existing threats, without adding a new one.
December 14, 2024 at 2:43 AM
That's kind of the point though, we will _not_ make it.
We're determined to leave wiping of us to the climate and other already existing threats, without adding a new one.
We're determined to leave wiping of us to the climate and other already existing threats, without adding a new one.
Origin of life is harder process than rational design. Mirror cell engineered in the lab would be fully baked, with all pathways needed for survival. Origins of life produces millions of years of wimpy barely-alive things. That's why we don't see any alternative trees of life - infant mortality.
December 14, 2024 at 2:41 AM
Origin of life is harder process than rational design. Mirror cell engineered in the lab would be fully baked, with all pathways needed for survival. Origins of life produces millions of years of wimpy barely-alive things. That's why we don't see any alternative trees of life - infant mortality.
If the original has mustache, then mirror clone would have a goatee.
December 14, 2024 at 2:37 AM
If the original has mustache, then mirror clone would have a goatee.
That's actually an not-happened existential crisis that might be calming to read about, because surprisingly and for a change we did the right thing.
December 14, 2024 at 2:33 AM
That's actually an not-happened existential crisis that might be calming to read about, because surprisingly and for a change we did the right thing.
Anyone fighting in favor of making mirror life can go eat a hotdog without ketchup. 🤢
December 14, 2024 at 1:27 AM
Anyone fighting in favor of making mirror life can go eat a hotdog without ketchup. 🤢
We kind of took the stove away. Or rather, decided not to build it.
December 14, 2024 at 1:24 AM
We kind of took the stove away. Or rather, decided not to build it.
not now, and not ever.
December 14, 2024 at 1:22 AM
not now, and not ever.
A week ago, we had less. Just people working on it without discussion of concerns.
That's progres I'd rather have than not.
That's progres I'd rather have than not.
December 13, 2024 at 11:32 PM
A week ago, we had less. Just people working on it without discussion of concerns.
That's progres I'd rather have than not.
That's progres I'd rather have than not.
True. We identified the threat. But we're also the people who have influence over this field, we're it. So preventing is on the table.
I would rather at least try, than ignore it and hope.
I would rather at least try, than ignore it and hope.
December 13, 2024 at 9:35 PM
True. We identified the threat. But we're also the people who have influence over this field, we're it. So preventing is on the table.
I would rather at least try, than ignore it and hope.
I would rather at least try, than ignore it and hope.
We're far enough away from actually knowing how to build the thing, that calling it quits right now is a pretty good safeguard. We're stopping early enough.
December 13, 2024 at 9:32 PM
We're far enough away from actually knowing how to build the thing, that calling it quits right now is a pretty good safeguard. We're stopping early enough.
Nah, this is actually good, calming reading. The take home message is that we identified the threat and prevented it.
I'd much more worry if the message was "trust us it'll be done safely", then you want to run for the hills.
I'd much more worry if the message was "trust us it'll be done safely", then you want to run for the hills.
December 13, 2024 at 9:30 PM
Nah, this is actually good, calming reading. The take home message is that we identified the threat and prevented it.
I'd much more worry if the message was "trust us it'll be done safely", then you want to run for the hills.
I'd much more worry if the message was "trust us it'll be done safely", then you want to run for the hills.
It's only 300 pages, light reading for the weekend.
December 13, 2024 at 9:28 PM
It's only 300 pages, light reading for the weekend.
D-protein therapeutics will be great. Same as Spiegelmer drugs.
I hope that discussion on not making a whole replicating mirror cell with serve to point out how non-replicating polymers are actually safe and have impactful applications.
I hope that discussion on not making a whole replicating mirror cell with serve to point out how non-replicating polymers are actually safe and have impactful applications.
December 13, 2024 at 9:27 PM
D-protein therapeutics will be great. Same as Spiegelmer drugs.
I hope that discussion on not making a whole replicating mirror cell with serve to point out how non-replicating polymers are actually safe and have impactful applications.
I hope that discussion on not making a whole replicating mirror cell with serve to point out how non-replicating polymers are actually safe and have impactful applications.
It would be a turtle in a world of hares.
But a turtle with an invisibility cloak, able to bide it's time and grow persistently.
But a turtle with an invisibility cloak, able to bide it's time and grow persistently.
December 13, 2024 at 9:24 PM
It would be a turtle in a world of hares.
But a turtle with an invisibility cloak, able to bide it's time and grow persistently.
But a turtle with an invisibility cloak, able to bide it's time and grow persistently.
We're more like ringing a dinner bell than alarm bell: we want to bring people together for a discussion. It's working: we're talking about it right here.
I would rather have those conversations while mirror cells do not exist, than have to scramble if they do exist and our concerns were right.
I would rather have those conversations while mirror cells do not exist, than have to scramble if they do exist and our concerns were right.
December 13, 2024 at 9:23 PM
We're more like ringing a dinner bell than alarm bell: we want to bring people together for a discussion. It's working: we're talking about it right here.
I would rather have those conversations while mirror cells do not exist, than have to scramble if they do exist and our concerns were right.
I would rather have those conversations while mirror cells do not exist, than have to scramble if they do exist and our concerns were right.