Kat Boniface
@katboniface.bsky.social
Riverside, CA
Equine History Collective
Renegade Research
https://katboniface.wordpress.com/the-glutamate-boss/
Equine History Collective
Renegade Research
https://katboniface.wordpress.com/the-glutamate-boss/
Whereas it seems like the hydroxy (oxe- and troxe-rutins) simply aren't metabolized. Not sure how much that point is oversold, but that would certainly change the effects. I could see each form working better for different purposes. (2/2)
April 14, 2025 at 5:23 PM
Whereas it seems like the hydroxy (oxe- and troxe-rutins) simply aren't metabolized. Not sure how much that point is oversold, but that would certainly change the effects. I could see each form working better for different purposes. (2/2)
I haven't been able to find much research looking at the hydroxy forms at all (much less in comparison!) The -hydrate forms (typically trihydrate) regularly underperform compared to quercetin-3-o-rutinoside (the most common form in parsely, buckwheat, pagoda tree), but metabolize similarly (1/2)
April 14, 2025 at 5:20 PM
I haven't been able to find much research looking at the hydroxy forms at all (much less in comparison!) The -hydrate forms (typically trihydrate) regularly underperform compared to quercetin-3-o-rutinoside (the most common form in parsely, buckwheat, pagoda tree), but metabolize similarly (1/2)
My loss of other languages was the first concrete evidence that something was very, very wrong.
March 16, 2025 at 5:18 PM
My loss of other languages was the first concrete evidence that something was very, very wrong.
And for folks outside @renegaderesearch.bsky.social, I am currently taking appointments to review labs or DNA, assist with communicating with your doctor, and of course discussion of the finer details of the glutamate system.
katboniface.wordpress.com/the-glutamat...
katboniface.wordpress.com/the-glutamat...
The Glutamate Boss
Services I am not a doctor, vet, or any other form of medical professional. I am a historian of technology with a background in animal science. I hold non-board certifications in equine nutrition, …
katboniface.wordpress.com
March 4, 2025 at 9:10 PM
And for folks outside @renegaderesearch.bsky.social, I am currently taking appointments to review labs or DNA, assist with communicating with your doctor, and of course discussion of the finer details of the glutamate system.
katboniface.wordpress.com/the-glutamat...
katboniface.wordpress.com/the-glutamat...
I can often be found with @renegaderesearch.bsky.social and @equinehistory.bsky.social
March 4, 2025 at 9:07 PM
I can often be found with @renegaderesearch.bsky.social and @equinehistory.bsky.social
Kainate! Yes!! It's role in mast cells is part of why I've been looking into it; rare to see a study really look at the subtype level (e.g. not just lumping all Kainate together, or even all non-NMDA).
March 4, 2025 at 8:55 PM
Kainate! Yes!! It's role in mast cells is part of why I've been looking into it; rare to see a study really look at the subtype level (e.g. not just lumping all Kainate together, or even all non-NMDA).
Can cause rebound effects, including increased acoustic startle ("anxiety"), irritability, muscle weakness.
March 4, 2025 at 8:54 PM
Can cause rebound effects, including increased acoustic startle ("anxiety"), irritability, muscle weakness.
Zzzquil as in diphenhydramine? Inhibits NMDA (competitive, channel rather than binding site- similar to magnesium but extreme); alters GABA (this effect will last longer); blocks acetylcholine central & peripheral (handle with care); and very mild SSRI- prozac was built from it!
March 4, 2025 at 8:53 PM
Zzzquil as in diphenhydramine? Inhibits NMDA (competitive, channel rather than binding site- similar to magnesium but extreme); alters GABA (this effect will last longer); blocks acetylcholine central & peripheral (handle with care); and very mild SSRI- prozac was built from it!
Working on a custom report with Genetic Life Hacks, focusing on the genes that are both over-represented in ME/CFS and are immediately actionable. Always happy for suggestions, right now we're starting with in born errors of metabolism and the glutamate system.
March 4, 2025 at 8:32 PM
Working on a custom report with Genetic Life Hacks, focusing on the genes that are both over-represented in ME/CFS and are immediately actionable. Always happy for suggestions, right now we're starting with in born errors of metabolism and the glutamate system.
Fascinating! I've come across valproic a few times due to it's inhibitory effects on NMDA and Kainate (both of which can be good or bad, depending on the starting state).
March 4, 2025 at 8:28 PM
Fascinating! I've come across valproic a few times due to it's inhibitory effects on NMDA and Kainate (both of which can be good or bad, depending on the starting state).
💯
90% of my breakthroughs at least have been due to my messing something up for my own system, or talking through things with folks who have had an unexpected reaction to something!
Probably very on brand that this is my first post here 😆
90% of my breakthroughs at least have been due to my messing something up for my own system, or talking through things with folks who have had an unexpected reaction to something!
Probably very on brand that this is my first post here 😆
November 21, 2024 at 9:12 PM
💯
90% of my breakthroughs at least have been due to my messing something up for my own system, or talking through things with folks who have had an unexpected reaction to something!
Probably very on brand that this is my first post here 😆
90% of my breakthroughs at least have been due to my messing something up for my own system, or talking through things with folks who have had an unexpected reaction to something!
Probably very on brand that this is my first post here 😆