Karen Slattery
@karen--s.bsky.social
Cancer immunologist with an interest in metabolism.
Delighted to have our work on ovarian cancer highlighted by Cancer Discovery News this week! 😊
ICYMI: Ascites-derived Lipid Uptake Drives NK Cell Dysfunction in Ovarian Cancer, a #ResearchWatch summary of a new study by @karen--s.bsky.social, @lydialynch.bsky.social, and colleagues at @ludwigcancer.bsky.social @princetonmolbio.bsky.social
aacrjournals.org/cdnews/news/...
aacrjournals.org/cdnews/news/...
Ascites-derived Lipid Uptake Drives NK Cell Dysfunction in Ovarian Cancer
Major Finding: Lipids derived from ascites are taken up by NK cells and drive NK cell dysfunction in ovarian cancer.
Concept: Polar lipids such as phosphatidylcholine disrupt NK plasma membrane order ...
aacrjournals.org
June 12, 2025 at 11:43 AM
Delighted to have our work on ovarian cancer highlighted by Cancer Discovery News this week! 😊
Thrilled to share our new study showing that lipids drive immune dysfunction in ovarian cancer — and that blocking lipid uptake through SR-B1 can prevent it! @lydialynch.bsky.social @tcddublin.bsky.social
Researchers led by Ludwig Princeton’s @lydialynch.bsky.social report that certain fats in ascites fluid—which accumulates as ovarian cancer spreads from the ovaries into the abdomen—sabotage anti-tumor immune responses and show how this effect might be blocked for immunotherapy. bit.ly/4jGuUtU
May 12, 2025 at 2:05 PM
Thrilled to share our new study showing that lipids drive immune dysfunction in ovarian cancer — and that blocking lipid uptake through SR-B1 can prevent it! @lydialynch.bsky.social @tcddublin.bsky.social
Reposted by Karen Slattery
Our paper @sciimmunology.bsky.social shows certain lipids are responsible for the immunosupression of ascites & propose blocking lipid uptake thru SCARB1 may help immunotherapy in ovarian cancer. Wonderful to collaborate with Donal Brennan, Marcia Haigis & super postdoc @karen--s.bsky.social
Researchers led by Ludwig Princeton’s @lydialynch.bsky.social report that certain fats in ascites fluid—which accumulates as ovarian cancer spreads from the ovaries into the abdomen—sabotage anti-tumor immune responses and show how this effect might be blocked for immunotherapy. bit.ly/4jGuUtU
May 12, 2025 at 1:28 PM
Our paper @sciimmunology.bsky.social shows certain lipids are responsible for the immunosupression of ascites & propose blocking lipid uptake thru SCARB1 may help immunotherapy in ovarian cancer. Wonderful to collaborate with Donal Brennan, Marcia Haigis & super postdoc @karen--s.bsky.social
I was honored to recieve the Translational Project of the Year Award at the Irish Cancer Society Awards last week! Thanks so much to the ICS for funding and acknowledging this work, and to @lydialynch.bsky.social for all of the support over the years! 😊🥰
February 24, 2025 at 8:45 PM
I was honored to recieve the Translational Project of the Year Award at the Irish Cancer Society Awards last week! Thanks so much to the ICS for funding and acknowledging this work, and to @lydialynch.bsky.social for all of the support over the years! 😊🥰
Reposted by Karen Slattery
I'm delighted to share a new story from our lab published today at @cp-cellmetabolism.bsky.social! In it, we describe how cellular therapies for cancer can be metabolically and epigenetically enhanced by redirecting how glucose is utilized during in vitro expansion. 1/ www.cell.com/cell-metabol...
Redirecting glucose flux during in vitro expansion generates epigenetically and metabolically superior T cells for cancer immunotherapy
T cell therapies for cancer currently rely on extensive in vitro expansion in hypermetabolic
conditions. Frisch et al. demonstrate that T cells grown in vitro perform extensive
aerobic glycolysis. Rer...
www.cell.com
January 28, 2025 at 6:34 PM
I'm delighted to share a new story from our lab published today at @cp-cellmetabolism.bsky.social! In it, we describe how cellular therapies for cancer can be metabolically and epigenetically enhanced by redirecting how glucose is utilized during in vitro expansion. 1/ www.cell.com/cell-metabol...
Reposted by Karen Slattery
I’m really proud to announce the 2025 Cancer Metabolism Showcase and Workshop, May 5th and 6th, 9:30 AM - 3 PM EST. This year, our Keynote Speaker is Dr. Jeffrey Rathmell from VUMC.
I'm excited to come together, talk science, and support researchers in our field.
www.cancermetabolismshowcase.org
I'm excited to come together, talk science, and support researchers in our field.
www.cancermetabolismshowcase.org
9:30 AM - 3 PM EST, May 5th and 6th, 2025
www.cancermetabolismshowcase.org
January 23, 2025 at 2:05 PM
I’m really proud to announce the 2025 Cancer Metabolism Showcase and Workshop, May 5th and 6th, 9:30 AM - 3 PM EST. This year, our Keynote Speaker is Dr. Jeffrey Rathmell from VUMC.
I'm excited to come together, talk science, and support researchers in our field.
www.cancermetabolismshowcase.org
I'm excited to come together, talk science, and support researchers in our field.
www.cancermetabolismshowcase.org
Reposted by Karen Slattery
Mitochondria consist of networks of cylindrical tubes, right? Not necessarily! - in our new preprint, @gavsturm.bsky.social investigates how mitochondria transiently adopt a beads-on-a-string morphology
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
December 23, 2024 at 5:49 PM
Mitochondria consist of networks of cylindrical tubes, right? Not necessarily! - in our new preprint, @gavsturm.bsky.social investigates how mitochondria transiently adopt a beads-on-a-string morphology
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Check out our new commentary on this interesting study by @justinaguerrero.bsky.social and team on Glut1 overexpressing CAR T cells. Excited to see what comes next for these metabolically enhanced T cells!
@davidfinlaytcd.bsky.social
@davidfinlaytcd.bsky.social
La dolce vita: fueling chimeric antigen receptor (CAR) T... : Immunometabolism
y of patients relapse, which is concomitant with poor CAR T cell persistence. Similarly, the efficacy of CAR T cell therapy is limited in solid tumors, largely due to tumor antigen heterogeneity, immu...
journals.lww.com
January 13, 2025 at 1:33 PM
Check out our new commentary on this interesting study by @justinaguerrero.bsky.social and team on Glut1 overexpressing CAR T cells. Excited to see what comes next for these metabolically enhanced T cells!
@davidfinlaytcd.bsky.social
@davidfinlaytcd.bsky.social
Reposted by Karen Slattery
Delighted to share our paper on adipose gd T cells making IL-17 every night for homeostasis, coordinating lipid metabolism after eating @natureportfolio.bsky.social Huge effort by whole team and collaborators to work this out. www.nature.com/articles/s41...
Article Metrics - Rhythmic IL-17 production by γδ T cells maintains adipose de novo lipogenesis | Nature
www.nature.com
December 19, 2024 at 1:05 AM
Delighted to share our paper on adipose gd T cells making IL-17 every night for homeostasis, coordinating lipid metabolism after eating @natureportfolio.bsky.social Huge effort by whole team and collaborators to work this out. www.nature.com/articles/s41...
Reposted by Karen Slattery
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
December 11, 2024 at 4:29 PM
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
Reposted by Karen Slattery
Working on immunometabolism? Or looking for people who do? Then here’s the starter pack for you! 😊 #Immunosky
go.bsky.app/MvxkA4Q
go.bsky.app/MvxkA4Q
November 24, 2024 at 1:35 PM
Working on immunometabolism? Or looking for people who do? Then here’s the starter pack for you! 😊 #Immunosky
go.bsky.app/MvxkA4Q
go.bsky.app/MvxkA4Q