4/4 Please also be aware about the mobility rules that apply for MSCA actions - no residence in Germany for more than 12 months in the last three years.

3/4 Based in scenic Kiel by the Baltic Sea, we offer a competitive salary, collaborative environment, and support for work-life balance. 🌊 Ready to make a difference? Apply by November 30th, 2025, and be part of our research team! 📅 Learn more & contact us here: c.kaleta@iem.uni-kiel.de #Hiring

2/4 You'll apply #metabolic #modeling integrating diverse OMICs data sets to reveal how the microbiome impacts cognitive function during menopause. You'll work closely with our partners at Jena University and the entire MenoBrain consortium (www.uniklinikum-jena.de/menobrain/en/). 🌟 #ScienceJobs

So, is this bacterial metabolite relevant in humans? With help from @kaletalab.bsky.social we predicted its production is significantly higher in the gut microbiomes of colorectal cancer patients. It is also present in cancer-associated microbiomes.

What does it actually do to cancer cells?

Our results suggest that uropathogens may depend on a broad network of metabolic interactions during infection, potentially unlocking new treatment strategies for UTIs. (7/7)

A closer look at the modeled communities revealed a complex network of metabolic interactions, including compounds implicated in UTI pathogenesis like sorbitol. (6/7)

Although the predicted metabolic fluxes showed mostly small differences post-metatranscriptomic data integration, we observed a notable reduction in overall flux due to the fastcore algorithm. (5/7)

We simulated the bacterial community using BacArena, integrating both metabolic models and context-specific metatranscriptomic data. (4/7)

Our findings reveal a diverse array of species within the uromicrobiome, extending beyond the commonly identified uropathogenic E. coli. (3/7)

In this study, we combined metabolic modeling with metatranscriptomics to study the uromicrobiome's metabolic interactions during infections in women. (2/7)