I missed this poll but this is a bit scary!!! 8 % said Ribociclib which is absolutely contraindicated and honestly I would be hesitant to start her on any cdk4/6 inhibitor with a QTc that high particularly given she is on seroquel. Speed dial to cardio-oncology! Education needed!

⭐Thank you everyone for participating in the 2nd poll on diarrhea 💩 management for our patient with HR+, HER2- MBC on a 1L CDK4/6i! Here are the results from that other site for reference 🐦❌ 📊👇

Let’s 🔎 closer at considerations for management of diarrhea 💩 associated with a CDK4/6i Tx. Please watch a short 📹 explaining what I would do. What are your experiences, Qs? Then access the full @PeerView #CME activity and get credit at PeerView.com/AGR @peerview.bsky.social

👍Thank you to all of you who participated in my 3rd poll on 2L Tx for a patient with HR+, HER2- #MBC progressing on a 1L CDK4/6i.
Here are the results 📊👇from that other site as a reference

☑️Which of the following 2L Tx options would you recommend for this patient with HR+, HER2- #MBC progressing on 1L palbociclib? Please answer & explain in a comment 💬 why you made the choice you did.
1️⃣Capecitabine
2️⃣Abemaciclib + fulvestrant
3️⃣Exemestane + everolimus
4️⃣Something else (Tell me 💬⬇️)

Our next case scenario looks at a patient with HR+, HER2- #MBC who has progressed on 1L CDK4/6i 💊 with palbociclib + ET. Please consider the case details, answer the following poll 📊 on what Tx option you would choose next, and share your reason in the comments 💬! @peerview.bsky.social

Thank you for participating in this #OncSky Thread 🧵 on individualizing Tx of HR+, HER2- #MBC. Here are some takeaways. I hope you enjoyed this as much as I did! To participate in the full Peer View #CME activity and to get credit, please visit PeerView.com/AGR.

Now, let’s explore 2L options in HR+, HER2- #MBC after progression on 1L CDK4/6i. Please watch the short 📹 explaining my choice and rationale. What are your thoughts, Qs? 🙋 Go to 👉 PeerView.com/AGR for full @peerview.bsky.social content & credit.

In addition to starting antidiarrheal tx & ⬆️ hydration to manage persistent/recurrent grade 2 diarrhea 💩 experienced by this patient, you hold ⚠️ abemaciclib until toxicity resolves to grade ≤1. When resuming CDK4/6i 💊 what dose would you use for abema?
1️⃣150 mg BID
2️⃣100 mg BID
3️⃣50 mg BID
4️⃣No idea!

Now, let’s 💬⁉️ about individualized selection of CDK4/6i 💊for 1L Tx of HR+, HER2- #MBC. Watch this short 📹 to hear my thoughts on this case, then share your comments + questions. You can also access the full @PeerView activity & claim #CME credits at PeerView.com/AGR @peerview.bsky.social

⏰ Time for our case 1️⃣ of a patient with ER+, PgR-, HER2- #MBC who also has well-controlled #mentalhealth and a baseline ❤️ QTc of 575 ms. Review the case details, answer the poll 📊 about your preferred 1L CDK4/6i, & comment 💬 with the rationale. What would you recommend and why?