kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F... 🎉 50 days free accesos🎉🎉 @bbajournals thanks

9/ Many thanks to @unsamoficial.bsky.social #EByNUNSAM #CONICET #Agencia i+d+i #UBA

@ebynunsam

@CONICETDialoga

@agenciaidiar

@Exactas_UBA

8/ 📢 This work is part of Antonella Leon's with contributions from Gabriela, Rocio and Facundo. Huge thanks to our collaborators Laura Estrada and Ignacio Salaberry for the N&B experiments! 🔬🙌

7/ Studying gene variants gives critical insights into disease mechanisms and genetic susceptibility. Understanding GPM6a’s role in neuropsychiatric disorders may improve diagnosis and therapeutic strategies in the future. 🏥🧠

6/ We also compared silico predictions with functional assays. Surprisingly, computational models didn’t always align with experimental results. This highlights the need to validate genetic risk factors with lab experiments! ⚠️

5/ Additionally, several nsSNPs weakened GPM6a-mediated cell aggregation, reinforcing the importance of its extracellular domains in the homophilic interaction.

4/ However, some nsSNPs disrupted GPM6a’s distributionat the membrane. One variant also altered GPM6a oligomerization, suggesting it plays a key role in homophilic cis interactions.

3/ We analyzed 13 non-synonymous SNPs (nsSNPs) in GPM6a’s extracellular domains of which 6 (T71P, T76I, M154V, F156Y, R163Q, T210N) impair GPM6a-induced neuronal development—but without altering expression, folding, or membrane localization. 🧬🔍

2/ GPM6a is crucial for neurite outgrowth, filopodia formation, and synapse maintenance. But how do genetic variations impact its function? 🤔

1/ Psychiatric disorders arise from complex interactions between genes & environment, often affecting neuronal morphogenesis. Our work focuses on GPM6a, a neuronal glycoprotein linked to schizophrenia, depression, and claustrophobia.

In 2023, we also decided to have three organizers in different continents to increase awareness and reach more researchers and trainees. We were still an EMBO and IUBMB event. This time the organizers were @stephgupton.bsky.social @christlet.bsky.social and Carlos Wilson

May I join it .. Thanks

Please add me !!!! Thanks