Justin Wilkins
@justinwilkins.bsky.social
Pharmacometrician, PhD. Senior consultant and founder at Occams, past president of the International Society of Pharmacometrics, co-developer of nlmixr2. Opinions my own. 🇿🇦🇩🇪🇬🇧🇸🇪🇨🇭🇪🇺🇺🇦
Wenn der Cybertruck ein deutsches Wort wäre, wäre es „Unstreichholzschachtelpanzergerät“
November 21, 2025 at 6:19 AM
Wenn der Cybertruck ein deutsches Wort wäre, wäre es „Unstreichholzschachtelpanzergerät“
We don’t see any at all around here. They are not compliant with European standards (too heavy, too many sharp edges) and are therefore not street legal
November 21, 2025 at 6:04 AM
We don’t see any at all around here. They are not compliant with European standards (too heavy, too many sharp edges) and are therefore not street legal
Not sure I can help with that one…
November 3, 2025 at 7:42 PM
Not sure I can help with that one…
Depends on the topic…?
November 1, 2025 at 10:13 PM
Depends on the topic…?
Reposted by Justin Wilkins
In short, acetaminophen exposure during pregnancy is not linked to the risk of developing autism, ADHD, or intellectual disability.
The study has been published in Journal of the American Medical Association (JAMA). YES, it is PEER-REVIEWED.
• jamanetwork.com/journals/jam...
🧪🧵⬇️
The study has been published in Journal of the American Medical Association (JAMA). YES, it is PEER-REVIEWED.
• jamanetwork.com/journals/jam...
🧪🧵⬇️
![Design, Setting, and Participants
This nationwide cohort study with sibling control analysis included a population-based sample of 2,480,797 children born in 1995 to 2019 in Sweden, with follow-up through December 31, 2021.
Exposure
Use of acetaminophen during pregnancy prospectively recorded from antenatal and prescription records.
Main Outcomes and Measures
Autism, ADHD, and intellectual disability based on International Classification of Diseases, Ninth Revision and International Classification of Diseases, Tenth Revision codes in health registers.
Results
In total, 185909 children (7.49%) were exposed to acetaminophen during pregnancy. Crude absolute risks at 10 years of age for those not exposed vs those exposed to acetaminophen were 1.33% vs 1.53% for autism, 2.46% vs 2.87% for ADHD, and 0.70% vs 0.82% for intellectual disability. In models without sibling control, ever-use vs no use of acetaminophen during pregnancy was associated with marginally increased risk of autism (hazard ratio [HR], 1.05 [95% CI, 1.02-1.08]; risk difference [RD] at 10 years of age, 0.09% [95% Cl,
-0.01% to 0.20%l), ADHD (HR, 1.07 [95% Cl, 1.05-1.10];
RD, 0.21% [95% Cl, 0.08%-0.34%]), and intellectual disability (HR, 1.05 [95% CI, 1.00-1.10]; RD, 0.04% [95% Cl, -0.04% to 0.12%]).
To address unobserved confounding, matched full sibling pairs were also analyzed. Sibling control analyses found no evidence that acetaminophen use during pregnancy was associated with autism (HR, 0.98 [95% Cl, 0.93-1.04]; RD, 0.02% [95% Cl, -0.14% to 0.18%l), ADHD (HR, 0.98 [95% Cl, 0.94-1.02]; RD, -0.02% [95% Cl, -0.21% to 0.15%]), or intellectual disability (HR, 1.01 195% Cl, 0.92-1.10]; RD, 0% [95% Cl, -0.10% to 0.13%1).](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:llgfbjvsqkaicezsf7mzjxr3/bafkreicpuvkboryiemrnkjuo7g2yj7garvjkjiw7i33ktwnguhri4csrn4@jpeg)
October 30, 2025 at 4:02 PM
In short, acetaminophen exposure during pregnancy is not linked to the risk of developing autism, ADHD, or intellectual disability.
The study has been published in Journal of the American Medical Association (JAMA). YES, it is PEER-REVIEWED.
• jamanetwork.com/journals/jam...
🧪🧵⬇️
The study has been published in Journal of the American Medical Association (JAMA). YES, it is PEER-REVIEWED.
• jamanetwork.com/journals/jam...
🧪🧵⬇️
We have problems with right-wing extremists just like everyone else. We also have a bit of a blind spot with the Israel-Palestine conflict. We have not, however, “normalised racism and state violence”. A bit of perspective, please.
October 30, 2025 at 6:53 AM
We have problems with right-wing extremists just like everyone else. We also have a bit of a blind spot with the Israel-Palestine conflict. We have not, however, “normalised racism and state violence”. A bit of perspective, please.
To be fair, no one’s accused me of being an LLM yet. And my wife assures me I am probably somewhere on the spectrum, so it’s a fair cop
October 28, 2025 at 5:55 AM
To be fair, no one’s accused me of being an LLM yet. And my wife assures me I am probably somewhere on the spectrum, so it’s a fair cop
But I‘ve been using emdashes for decades 😬
October 27, 2025 at 10:45 PM
But I‘ve been using emdashes for decades 😬
Truer words were never typed
September 8, 2025 at 9:54 PM
Truer words were never typed
The Mist is my favourite King piece, but I really struggle with the (excellent) movie because of the ending. I have kids and it hits very hard.
August 27, 2025 at 6:45 PM
The Mist is my favourite King piece, but I really struggle with the (excellent) movie because of the ending. I have kids and it hits very hard.
Oh, he’s racist as well. What a surprise
August 27, 2025 at 6:22 PM
Oh, he’s racist as well. What a surprise
Huh. Mine was considerably stupider.
August 8, 2025 at 8:17 PM
Huh. Mine was considerably stupider.
Can relate. I used to batch Thai green curry, lasted me for a week and got better with every reheat 🌶️
July 27, 2025 at 9:27 AM
Can relate. I used to batch Thai green curry, lasted me for a week and got better with every reheat 🌶️
I think I understood. :-)
July 26, 2025 at 8:24 AM
I think I understood. :-)
It’s bloody hard, to be sure. We have family members with gluten and dairy intolerance, so we really have no choice but to cook daily.
Working from home obviously helps a huge amount. Can’t imagine how much more difficult it is for people who don’t have that luxury.
Working from home obviously helps a huge amount. Can’t imagine how much more difficult it is for people who don’t have that luxury.
July 26, 2025 at 7:37 AM
It’s bloody hard, to be sure. We have family members with gluten and dairy intolerance, so we really have no choice but to cook daily.
Working from home obviously helps a huge amount. Can’t imagine how much more difficult it is for people who don’t have that luxury.
Working from home obviously helps a huge amount. Can’t imagine how much more difficult it is for people who don’t have that luxury.
We’ll just have to agree to disagree there
June 16, 2025 at 5:07 AM
We’ll just have to agree to disagree there
Hard disagree. Yeah, ageing him up was a terrible mistake, but Taylor’s run redeemed it pretty thoroughly
June 15, 2025 at 7:39 PM
Hard disagree. Yeah, ageing him up was a terrible mistake, but Taylor’s run redeemed it pretty thoroughly