Justin R. Gregg, MD
justinrgregg.bsky.social
Justin R. Gregg, MD
@justinrgregg.bsky.social
Associate Professor of #Urology and Health Disparities Research at MD Anderson Cancer Center. Focused on #prostatecancer treatment and translational and behavioral research. @VanderbiltU alum.
(8/8) My key takeaway here is that ANY of the prescribed dietary changes had a modest effect on weight loss (though more loss would have been better!).

While these diets aren’t used as often now, the lesson for patients is that the best weight loss diet is the one they can STICK TO!
December 4, 2024 at 8:21 PM
(7/8) Finally, a major point here is that weight loss directly correlates with compliance (more compliant = more weight loss). Perhaps a boring finding, but important to the big picture:
December 4, 2024 at 8:21 PM
(6/8) Now for weight loss. In all groups, weight loss was present at 1 year (figure below). There was no difference between the groups (P=0.4). Weight loss ranged from 8.6 lbs to 14.6.

Not showing the data, but cardiovascular markers (e.g. LDL, insulin, CRP) had a moderate decrease.
December 4, 2024 at 8:21 PM
(5/8) Starting with adherence, the below figure shows adherence by diet (Y axis) over time (x axis). 10 is perfect 1 is none.

This shows something that many of us know: adherence to a diet goes down over time!
December 4, 2024 at 8:21 PM
(4/8) Primary outcomes were weight change and cardiac risk factors (labs). They also looked at adherence.
December 4, 2024 at 8:21 PM
(3/8) In the study, 160 participants were randomized to 1 of 4 diets:
1. Atkins (low carb)
2. Zone (macro targets)
3. Weight watchers (calorie restrict)
4. Ornish (fat restrict)

Bit of a blast from the past, huh?
December 4, 2024 at 8:21 PM
(2/8) Today we're taking a look at how diet can affect weight loss.

Here is a 2005 paper from Dansinger et al. in JAMA that examines the effect of 4 different diets on weight loss and cardiovascular risk factors at 1 year:

jamanetwork.com/journals/jam...
Comparison of the Atkins, Ornish, Weight Watchers, and Zone Diets for Weight Loss and Heart Disease Risk Reduction
Context The scarcity of data addressing the health effects of popular diets is an important public health concern, especially since patients and physicians are interested in using popular diets as ind...
jamanetwork.com
December 4, 2024 at 8:21 PM