Justin Perry - Perry Lab
@justinperryphd.bsky.social
Scientist @MSKCC | We study dead cell clearance / phagocytosis | #Immunology | #CellBiology | #Metabolism | views my own, not MSKCC. FreeCon Signatory. Alaskan.
It does raise the question of why the thymus hate? There should be a campaign to stop the thymus hate!
October 6, 2025 at 2:51 PM
It does raise the question of why the thymus hate? There should be a campaign to stop the thymus hate!
I think my lab works on immunometabolism 🤔🤷♂️🤣
September 27, 2025 at 11:49 PM
I think my lab works on immunometabolism 🤔🤷♂️🤣
Cool! Have you built in a way to integrate published phenotypes?
September 9, 2025 at 1:47 AM
Cool! Have you built in a way to integrate published phenotypes?
What's the concern? They awarded it this most recent cycle. www.research.gov/grfp/Login.do
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www.research.gov
August 29, 2025 at 4:14 PM
What's the concern? They awarded it this most recent cycle. www.research.gov/grfp/Login.do
Makes me miss the talented people back home in AK. Was just back at Forest Fair, another reminder of how great it is there.
July 28, 2025 at 9:17 PM
Makes me miss the talented people back home in AK. Was just back at Forest Fair, another reminder of how great it is there.
Interesting. Congrats.
July 2, 2025 at 4:42 PM
Interesting. Congrats.
Update: Free-ish link: rdcu.be/eqx2G
Early life high fructose impairs microglial phagocytosis and neurodevelopment
Nature - Exposure of mice to high fructose during gestation or early postnatal life causes decreased microglial phagocytosis during brain development and leads to anxiety-like behaviour in...
rdcu.be
June 11, 2025 at 4:11 PM
Update: Free-ish link: rdcu.be/eqx2G
3) A bit hidden in the supplement, but we propose a mostly-observational, not at all proven, mechanism of action in which HK2 localization is responsible for the defect in phagocytosis and altered metabolism. Very excited to work on this and the role of GLUT5/fructose in aging!
June 11, 2025 at 3:43 PM
3) A bit hidden in the supplement, but we propose a mostly-observational, not at all proven, mechanism of action in which HK2 localization is responsible for the defect in phagocytosis and altered metabolism. Very excited to work on this and the role of GLUT5/fructose in aging!
2) Quantitation of fructose in the brain and important clarification that our effect did not seem to be due to circulating- or CNS-derived glucose (polyol pathway) or circulating lactate.
June 11, 2025 at 3:43 PM
2) Quantitation of fructose in the brain and important clarification that our effect did not seem to be due to circulating- or CNS-derived glucose (polyol pathway) or circulating lactate.
What was new in the revision? A few things:
1) We created SLC2A5 (GLUT5) floxed mice to delete the transporter from myeloid cells during embryogenesis. This completely reversed the phagocytosis, metabolism, and behavioral phenotypes due to high fructose exposure.
1) We created SLC2A5 (GLUT5) floxed mice to delete the transporter from myeloid cells during embryogenesis. This completely reversed the phagocytosis, metabolism, and behavioral phenotypes due to high fructose exposure.
June 11, 2025 at 3:43 PM
What was new in the revision? A few things:
1) We created SLC2A5 (GLUT5) floxed mice to delete the transporter from myeloid cells during embryogenesis. This completely reversed the phagocytosis, metabolism, and behavioral phenotypes due to high fructose exposure.
1) We created SLC2A5 (GLUT5) floxed mice to delete the transporter from myeloid cells during embryogenesis. This completely reversed the phagocytosis, metabolism, and behavioral phenotypes due to high fructose exposure.
@mskcancercenter.bsky.social has a nice writeup on it here: www.mskcc.org/news/high-fr...
And we have a preprint here: pubmed.ncbi.nlm.nih.gov/37645894/ with an explainer here x.com/JustinPerryP...
And we have a preprint here: pubmed.ncbi.nlm.nih.gov/37645894/ with an explainer here x.com/JustinPerryP...
High-Fructose Diet Harms Neurodevelopment and Leads to Anxiety in Mice, MSK Study Finds
A new laboratory study from MSK is shedding light on the mechanisms by which high fructose consumption early in life may directly impact brain development and increase the risk of anxiety disorders la...
www.mskcc.org
June 11, 2025 at 3:25 PM
@mskcancercenter.bsky.social has a nice writeup on it here: www.mskcc.org/news/high-fr...
And we have a preprint here: pubmed.ncbi.nlm.nih.gov/37645894/ with an explainer here x.com/JustinPerryP...
And we have a preprint here: pubmed.ncbi.nlm.nih.gov/37645894/ with an explainer here x.com/JustinPerryP...
Cool story. Wonder what this means when considering our finding that microglia (numbers defined by conventional protein markers, anyway) were surprisingly unaffected. rdcu.be/eoaRm
What are these other factors? 🤔
What are these other factors? 🤔
WNK1 mediates M-CSF-induced macropinocytosis to enforce macrophage lineage fidelity
Nature Communications - Tissue-resident macrophages (TRM) are important mediators of local immunity. Here the authors show that the deficiency or inhibition of a kinase, WNK1, unlinks macrophage...
rdcu.be
June 3, 2025 at 4:20 PM
Cool story. Wonder what this means when considering our finding that microglia (numbers defined by conventional protein markers, anyway) were surprisingly unaffected. rdcu.be/eoaRm
What are these other factors? 🤔
What are these other factors? 🤔
Naturally, lots of questions remaining, including about how WNK1 is actually functioning to inform macrophage lineage commitment. Nevertheless, excited to see this story out. It's one of the best I have ever been a part of. @edinuni-irr.bsky.social writeup is here: edin.ac/3FtYS5B
Cell ‘drinking’ and enzyme activation shape immune cell fate
New study shows that a specific growth factor causes early-stage immune cells (macrophage precursors) to ‘drink’, which activates a special enzyme. This cell drinking and enzyme activation determines ...
edin.ac
June 2, 2025 at 1:25 AM
Naturally, lots of questions remaining, including about how WNK1 is actually functioning to inform macrophage lineage commitment. Nevertheless, excited to see this story out. It's one of the best I have ever been a part of. @edinuni-irr.bsky.social writeup is here: edin.ac/3FtYS5B
5. Alissa then performed a whole bunch of experiments to demonstrate that WNK1 acts downstream of CSF1R (M-CSF receptor) to inform macrophage differentiation.
June 2, 2025 at 1:25 AM
5. Alissa then performed a whole bunch of experiments to demonstrate that WNK1 acts downstream of CSF1R (M-CSF receptor) to inform macrophage differentiation.
4. M-CSF-stimulated macropinocytosis is required for differentiation of myeloid progenitors into macrophages🤯.
June 2, 2025 at 1:25 AM
4. M-CSF-stimulated macropinocytosis is required for differentiation of myeloid progenitors into macrophages🤯.