URochester Biology has a tenure-track position open in evolutionary genetics/genomics, particularly those with mathematical, computational, and/or quantitative approaches.
Deadline: Nov 10
apply.interfolio.com/173431
Bio Dept retreat photo for attention

Work is sometimes fun, having fun requires some work. I've found a blend of sampling yeast and riding that is a euphoric mix, and makes me wonder why its taken so many years to find. Route is via the finger lakes national forest, 16 miles round trip, 1hr biking straight out, 5 hours sampling back.

Great to hear back in the day stories, chum with alumns and progeny research at Roc-Fest, a celebration of Orr, Werren, Eickbush, and Jaenike and their contributions to adaptation, speciation, and selfish genetic elements. sites.google.com/view/rocfest...
I contributed wine:

Very pleased to share this long term (nearly 20 years) study of yeasts isolated from vineyards and forests, now up on biorxiv:
www.biorxiv.org/content/10.1...

Ella Al-Shamahi (muslim missionary turned evolutionary biologist, host of BBC human series) opinion piece on why follow the science fails.
www.washingtonpost.com/opinions/202...

Second, we generated AF2 structures for both S. uvarum and S. cerevisiae proteins and found that S. cerevisiae amino acids were consistently predicted to be more stabilizing (ΔΔG) than S. uvarum amino acids.

We conducted two additional lines of investigation into protein stability differences. First, we purified two proteins (Guk1 and Aha1) from each species and found their thermal stability differences are structurally encoded.

We used thermal proteomic profiling to measure temperature induced aggregation as an indicator of stability and found a small but consistent shift in melting temperatures between S. cerevisiae and S. uvarum.

We examined divergence in protein stability in Saccharomyces species that have evolved substantial differences in thermotolerance.