Sometimes not, but that’s the beauty of it. I save so much time by not fiddling around on the computer until the sketched panels are mostly set!

Yes! I wholeheartedly recommend this method.

Congratulations to Dr. Nandadasa (one of UMass Chan’s rising stars), his research group, and his collaborators! It was such a joy for me to think about cilia and developmental signaling again while helping with this project. Check out the full paper here:
www.nature.com/articles/s41...

Incredibly, several patient mutations occur exactly on or around this dotted line. Understanding how TMEM67 is split into its two functional forms could explain why its various mutations cause such a wide range of symptoms and provide new directions for therapeutic development.

When TMEM67 is cut at this site, half of the protein goes to the base of the cilium to direct its formation and function. When the protein remains whole, however, it stays at the cell surface to regulate Wnt signaling!

Dr. Nandadasa's team discovered a conserved cut site within TMEM67’s protein sequence – like a dotted line for a pair of molecular scissors (extracellular matrix metalloprotease ADAMTS9 ✂️).

Gorgeous shot! I thought this was a painting at first!

Also Luddite!? C’mon NYT!