John R. Ussher
@jussherlab.bsky.social
Proud father, loving husband, enthusiastic scientist, Detroit Red Wings & Lions diehard, trekkie/space lover, casual Madden player and Game of Thrones Fanatic
Looking forward to sharing new research stories from our lab in 2026, Happy Holidays and Happy New Year to all!
December 22, 2025 at 7:12 PM
Looking forward to sharing new research stories from our lab in 2026, Happy Holidays and Happy New Year to all!
Last, very happy to share the first original research paper from PhD student, Tanin Shafaati, demonstrating that increases in ketones do not benefit cardiac parameters in a mouse model of #BarthSyndrome
www.frontierspartnerships.org/journals/jou...
www.frontierspartnerships.org/journals/jou...
Frontiers Publishing Partnerships | Pharmacological increases in circulating ketones fail to alleviate the hypertrophic cardiomyopathy present in the Tafazzin knockdown mouse model of Barth syndrome
ObjectiveMutations in the tafazzin gene lead to impaired remodeling of cardiolipin, thereby impairing mitochondrial function and causing Barth syndrome (BTHS...
www.frontierspartnerships.org
December 22, 2025 at 7:12 PM
Last, very happy to share the first original research paper from PhD student, Tanin Shafaati, demonstrating that increases in ketones do not benefit cardiac parameters in a mouse model of #BarthSyndrome
www.frontierspartnerships.org/journals/jou...
www.frontierspartnerships.org/journals/jou...
Also very excited to share the latest first author original research paper of Jordan's, demonstrating that #metformin can alleviate #diastolic_dysfunction in #Diabetic_Cardiomyopathy
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Metformin alleviates diastolic dysfunction in mice with experimental diabetic cardiomyopathy
The first line therapy for managing type 2 diabetes (T2D), metformin, has been shown to be cardioprotective in humans and several preclinical models o…
www.sciencedirect.com
December 22, 2025 at 7:12 PM
Also very excited to share the latest first author original research paper of Jordan's, demonstrating that #metformin can alleviate #diastolic_dysfunction in #Diabetic_Cardiomyopathy
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
First, very excited to share our latest review on #PDH and #glucose_oxidation as a target for #Diabetic_Cardiomyopathy courtesy of PhD student Jordan Chan
journals.physiology.org/doi/full/10....
journals.physiology.org/doi/full/10....
Metabolic modulation of pyruvate dehydrogenase and glucose oxidation in diabetic cardiomyopathy: pathways, perspectives, and potentials | American Journal of Physiology-Heart and Circulatory Physiolog...
Individuals living with obesity and/or type 2 diabetes (T2D) are at a disproportionately high risk of developing cardiovascular disease. This includes diabetic cardiomyopathy (DbCM), a condition chara...
journals.physiology.org
December 22, 2025 at 7:12 PM
First, very excited to share our latest review on #PDH and #glucose_oxidation as a target for #Diabetic_Cardiomyopathy courtesy of PhD student Jordan Chan
journals.physiology.org/doi/full/10....
journals.physiology.org/doi/full/10....