Finally, by looking at the stability of neural activity across days, we describe a major developmental transition that coincides with the emergence of arousal state modulation.

After making sure tracking was accurate, we quantified some basic activity statistics of the tracked neurons, showing an increase in rate, decrease in pairwise correlations, loss of spatial structure and a decrease in dimensionality of spontaneous activity.

We developed and evaluated a new cell tracking algorithm called Track2p, that allowed us to overcome these issues and track hundreds of neurons per mouse during the second postnatal week of neocortical development. During this time the weight and (estimated) brain volume increased by almost 50% 😱

How does a neuron get its activity? 👀

Check out our latest preprint, where we tracked the activity of the same neurons throughout early postnatal development: www.biorxiv.org/content/10.1...

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