Julian Stamp
@julian-stamp.bsky.social
PhD Candidate @ Center for Computational Molecular Biology, Brown University
Reposted by Julian Stamp
📣Online now!
📄Sparse modeling of interactions enables fast detection of genome-wide epistasis in biobank-scale studies
🧑🤝🧑 @lcrawford.bsky.social @julian-stamp.bsky.social & co
📄Sparse modeling of interactions enables fast detection of genome-wide epistasis in biobank-scale studies
🧑🤝🧑 @lcrawford.bsky.social @julian-stamp.bsky.social & co
Sparse modeling of interactions enables fast detection of genome-wide epistasis in biobank-scale studies
The sparse marginal epistasis test overcomes computational limitations of previous
mapping approaches by focusing its epistatic search to regions of the genome that
have some known functional relation...
www.cell.com
July 29, 2025 at 3:28 PM
📣Online now!
📄Sparse modeling of interactions enables fast detection of genome-wide epistasis in biobank-scale studies
🧑🤝🧑 @lcrawford.bsky.social @julian-stamp.bsky.social & co
📄Sparse modeling of interactions enables fast detection of genome-wide epistasis in biobank-scale studies
🧑🤝🧑 @lcrawford.bsky.social @julian-stamp.bsky.social & co
Looking forward to presenting my work at ISMB 2025!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Sparse modeling of interactions enables fast detection of genome-wide epistasis in biobank-scale studies
The lack of computational methods capable of detecting epistasis in biobanks has led to uncertainty about the role of non-additive genetic effects on complex trait variation. The marginal epistasis fr...
www.biorxiv.org
June 2, 2025 at 10:04 PM
Looking forward to presenting my work at ISMB 2025!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Our recent R-package for the Sparse Marginal Epistasis test (smer) is mentioned on a blog post about the Top 40 New CRAN packages!
www.r-bloggers.com/2025/02/janu...
www.r-bloggers.com/2025/02/janu...
January 2025 Top 40 New CRAN Packages | R-bloggers
In January, one hundred eighty-six new packages made it to CRAN. Here are my Top 40 picks in sixteen categories: Archaeology, Artificial Intelligence, Computational Methods, Ecology, Epidemiology, Fin...
www.r-bloggers.com
March 7, 2025 at 4:02 PM
Our recent R-package for the Sparse Marginal Epistasis test (smer) is mentioned on a blog post about the Top 40 New CRAN packages!
www.r-bloggers.com/2025/02/janu...
www.r-bloggers.com/2025/02/janu...
Reposted by Julian Stamp
Quick post to close out the week - in our newest preprint,
@julian-stamp.bsky.social scales the marginal epistasis test to work on biobanks! The key is that using trait-specific information to induce sparsity in the modeled gene-interactions greatly improves both runtime and power
@julian-stamp.bsky.social scales the marginal epistasis test to work on biobanks! The key is that using trait-specific information to induce sparsity in the modeled gene-interactions greatly improves both runtime and power
Can we find epistasis in human traits? To help, in our preprint, we present the most scalable and powerful framework for detecting epistasis to date: the “sparse marginal epistasis test” (SME).
Thank you @lcrawford.bsky.social, @sampatsmith.bsky.social, Dan Weinreich!
doi.org/10.1101/2025...
1/6
Thank you @lcrawford.bsky.social, @sampatsmith.bsky.social, Dan Weinreich!
doi.org/10.1101/2025...
1/6
Sparse modeling of interactions enables fast detection of genome-wide epistasis in biobank-scale studies
The lack of computational methods capable of detecting epistasis in biobanks has led to uncertainty about the role of non-additive genetic effects on complex trait variation. The marginal epistasis fr...
doi.org
January 17, 2025 at 9:22 PM
Quick post to close out the week - in our newest preprint,
@julian-stamp.bsky.social scales the marginal epistasis test to work on biobanks! The key is that using trait-specific information to induce sparsity in the modeled gene-interactions greatly improves both runtime and power
@julian-stamp.bsky.social scales the marginal epistasis test to work on biobanks! The key is that using trait-specific information to induce sparsity in the modeled gene-interactions greatly improves both runtime and power
Can we find epistasis in human traits? To help, in our preprint, we present the most scalable and powerful framework for detecting epistasis to date: the “sparse marginal epistasis test” (SME).
Thank you @lcrawford.bsky.social, @sampatsmith.bsky.social, Dan Weinreich!
doi.org/10.1101/2025...
1/6
Thank you @lcrawford.bsky.social, @sampatsmith.bsky.social, Dan Weinreich!
doi.org/10.1101/2025...
1/6
Sparse modeling of interactions enables fast detection of genome-wide epistasis in biobank-scale studies
The lack of computational methods capable of detecting epistasis in biobanks has led to uncertainty about the role of non-additive genetic effects on complex trait variation. The marginal epistasis fr...
doi.org
January 17, 2025 at 4:46 PM
Can we find epistasis in human traits? To help, in our preprint, we present the most scalable and powerful framework for detecting epistasis to date: the “sparse marginal epistasis test” (SME).
Thank you @lcrawford.bsky.social, @sampatsmith.bsky.social, Dan Weinreich!
doi.org/10.1101/2025...
1/6
Thank you @lcrawford.bsky.social, @sampatsmith.bsky.social, Dan Weinreich!
doi.org/10.1101/2025...
1/6
Reposted by Julian Stamp
I know I’m not supposed to judge a book by it’s cover but this is so beautiful, Daniel Weinreich! Love Ernst Haeckel‘s drawings.
October 15, 2023 at 1:33 PM
I know I’m not supposed to judge a book by it’s cover but this is so beautiful, Daniel Weinreich! Love Ernst Haeckel‘s drawings.
Reposted by Julian Stamp
Sparse modeling of interactions enables fast detection of genome-wide epistasis in biobank-scale studies https://www.biorxiv.org/content/10.1101/2025.01.11.632557v1
January 14, 2025 at 12:32 PM
Sparse modeling of interactions enables fast detection of genome-wide epistasis in biobank-scale studies https://www.biorxiv.org/content/10.1101/2025.01.11.632557v1
Reposted by Julian Stamp
Sparse modeling of interactions enables fast detection of genome-wide epistasis in biobank-scale studies https://www.biorxiv.org/content/10.1101/2025.01.11.632557v1
January 14, 2025 at 12:32 PM
Sparse modeling of interactions enables fast detection of genome-wide epistasis in biobank-scale studies https://www.biorxiv.org/content/10.1101/2025.01.11.632557v1