@judeydaros.bsky.social
Reposted
Excited to share this one! We developed an in vivo model for specific manipulation of transfer RNA acetylation and found it serves as a sentinel modification whose loss causes ribosome stalling and stress signaling. Implications for a genetic disorder and cancer.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Transfer RNA acetylation regulates in vivo mammalian stress signaling
An ancient tRNA modification is used by mammalian cells to coordinate protein translation and adaptive signaling.
www.science.org
March 20, 2025 at 1:42 AM
Excited to share this one! We developed an in vivo model for specific manipulation of transfer RNA acetylation and found it serves as a sentinel modification whose loss causes ribosome stalling and stress signaling. Implications for a genetic disorder and cancer.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...