Full article, available for free here: t.co/yp2WGxns69

CONCLUSIONS:

PROPOSAL: Careful assessment of alcohol use and metabolic dysfunction in individuals with suspected steatotic liver disease.

One very important point: The association between alcohol and metabolic syndrome (pathophysiological mechanisms). Alcohol itself produces features of metabolic dysfunction

Attributable risk of the leading drivers of steatotic liver disease, including alcohol use, increased adiposity and obesity, diabetes, dyslipidemia, and arterial hypertension

Here we discuss:
-Importance of comprehensive history of alcohol use
-Impact of alcohol on metabolic syndrome criteria
-Longitudinal assessment of metabolic dysfunction and alcohol use
-Challenges in quantifying alcohol use
-Need for integrated approaches to manage MetALD

-Rare, but disulfiram is a notable exception🚨
-85% of cases attributed to Disulfiram
-Mortality or Transplant in 27% cases of Disulfiram-induced DILI.
-71% pts with severe or fatal disulfiram DILI had underlying liver disease

Can we please stop using Disulfiram in ALD?