Juan J. Fraire-Zamora
@juanjo-fraire.bsky.social
Scientists in #ReproMed | R&D @Eugin Group | #ESHREjc and FoR editor | Maths in biology | Mexican food lover | Views are my own
Reposted by Juan J. Fraire-Zamora
Human Reproduction turns 40! 🎉
We’re celebrating by revisiting landmark papers with commentaries from original authors. First up: Leese & Gardner revisit their 1989 study (Hardy et al., 1989 – doi.org/10.1093/humr...) with a new commentary (Leese & Gardner, 2026 – doi.org/10.1093/humr...).
We’re celebrating by revisiting landmark papers with commentaries from original authors. First up: Leese & Gardner revisit their 1989 study (Hardy et al., 1989 – doi.org/10.1093/humr...) with a new commentary (Leese & Gardner, 2026 – doi.org/10.1093/humr...).
February 3, 2026 at 8:00 AM
Human Reproduction turns 40! 🎉
We’re celebrating by revisiting landmark papers with commentaries from original authors. First up: Leese & Gardner revisit their 1989 study (Hardy et al., 1989 – doi.org/10.1093/humr...) with a new commentary (Leese & Gardner, 2026 – doi.org/10.1093/humr...).
We’re celebrating by revisiting landmark papers with commentaries from original authors. First up: Leese & Gardner revisit their 1989 study (Hardy et al., 1989 – doi.org/10.1093/humr...) with a new commentary (Leese & Gardner, 2026 – doi.org/10.1093/humr...).
Reposted by Juan J. Fraire-Zamora
Many thanks to all participants, experts, authors and to @gliperis.bsky.social and his team for leading this great first Bluesky edition of the #ESHREjc 🦋
See you next time! 🙌
See you next time! 🙌
January 31, 2026 at 4:01 PM
Many thanks to all participants, experts, authors and to @gliperis.bsky.social and his team for leading this great first Bluesky edition of the #ESHREjc 🦋
See you next time! 🙌
See you next time! 🙌
Reposted by Juan J. Fraire-Zamora
🔥 Thank you everyone for attending the #ESHREjc and the first one hosted on Bluesky
Many thanks to our experts for the insightful discussion on the multifaceted role of the oocyte cortex @rvassena.bsky.social @paolavigano.bsky.social
And the # ESHREjc team 💫
Until next time! 👋🏻
Many thanks to our experts for the insightful discussion on the multifaceted role of the oocyte cortex @rvassena.bsky.social @paolavigano.bsky.social
And the # ESHREjc team 💫
Until next time! 👋🏻
Many thanks to all participants, experts, authors and to @gliperis.bsky.social and his team for leading this great first Bluesky edition of the #ESHREjc 🦋
See you next time! 🙌
See you next time! 🙌
January 31, 2026 at 4:05 PM
🔥 Thank you everyone for attending the #ESHREjc and the first one hosted on Bluesky
Many thanks to our experts for the insightful discussion on the multifaceted role of the oocyte cortex @rvassena.bsky.social @paolavigano.bsky.social
And the # ESHREjc team 💫
Until next time! 👋🏻
Many thanks to our experts for the insightful discussion on the multifaceted role of the oocyte cortex @rvassena.bsky.social @paolavigano.bsky.social
And the # ESHREjc team 💫
Until next time! 👋🏻
Here the summary of our discussion for Q3 on biomechanic parameters of oocyte developmental competence #ESHREjc
@eshre.bsky.social
@eshre.bsky.social
January 31, 2026 at 3:26 PM
Here the summary of our discussion for Q3 on biomechanic parameters of oocyte developmental competence #ESHREjc
@eshre.bsky.social
@eshre.bsky.social
Q4 waiting for your comments! #ESHREjc
Q4:Given that the cortex is a part of the interface between the oocyte and cumulus cells, how might abnormalities in the follicular environment alter cortical signaling or architecture, and how could these changes be detected through non-invasive follicular fluid or cumulus cell biomarkers?
#ESHREjc
#ESHREjc
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ALT: a card that says have an egg-stra egg-cellent day with a blue penguin
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January 30, 2026 at 5:10 PM
Q4 waiting for your comments! #ESHREjc
Q3. Coticchio et al suggest cortical properties (stiffness, viscoelasticity) could be biomarkers of oocyte developmental competence. Which technologies 🧫🔬🤖could realistically be applied in an IVF lab 👩🏻🔬 to measure cortex mechanics and what are the major barriers to clinical 🧑🏻⚕️ translation? #ESHREjc
a circle with a blue wave in it
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January 30, 2026 at 4:49 PM
Q3. Coticchio et al suggest cortical properties (stiffness, viscoelasticity) could be biomarkers of oocyte developmental competence. Which technologies 🧫🔬🤖could realistically be applied in an IVF lab 👩🏻🔬 to measure cortex mechanics and what are the major barriers to clinical 🧑🏻⚕️ translation? #ESHREjc
Q2 is now rolling! #ESHREjc
Q2: The paper proposed that cortical dysregulation can lead to blastomeri fragmentation and reduced blastocyst quality. What are the proposed mechanisms by which ectopic chromosomal signaling or cortical instability leads to abnormal cleavage patterns in early embryos? #ESHREjc
January 30, 2026 at 4:33 PM
Q2 is now rolling! #ESHREjc
Q1 is out for discussion! #ESHREjc
Q1. How do the structural components of the oocyte cortex (e.g., actin, myosin-!, pERM, Arp2/3, Fyn kinases) dynamically remodel during the transitions from GV to MIl and how do these changes mechanistically support spindle positioning and polar body extrusion? #ESHREjc
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January 30, 2026 at 4:14 PM
Q1 is out for discussion! #ESHREjc
Reposted by Juan J. Fraire-Zamora
WELCOME everyone to the first #ESHREjc on Bluesky to talk all about the
Oocyte Cortex: Fertility’s Hidden Control Layer #ESHREjc
Paper ➡️ pubmed.ncbi.nlm.nih.gov/41206604/
Oocyte Cortex: Fertility’s Hidden Control Layer #ESHREjc
Paper ➡️ pubmed.ncbi.nlm.nih.gov/41206604/
The emerging role of the oocyte cortical domain in maturation, fertilization, and development - PubMed
The cell cortex, a cytoskeletal network with regulatory signalling pathways, is localized beneath the cell membrane: it is especially prominent in mammalian oocytes. As in other cells, the cortex ensures appropriate shape and robustness of oocytes. It is also involved in other key and more specific …
pubmed.ncbi.nlm.nih.gov
January 30, 2026 at 4:03 PM
WELCOME everyone to the first #ESHREjc on Bluesky to talk all about the
Oocyte Cortex: Fertility’s Hidden Control Layer #ESHREjc
Paper ➡️ pubmed.ncbi.nlm.nih.gov/41206604/
Oocyte Cortex: Fertility’s Hidden Control Layer #ESHREjc
Paper ➡️ pubmed.ncbi.nlm.nih.gov/41206604/
Reposted by Juan J. Fraire-Zamora
@gliperis.bsky.social will be the lead moderator of this #ESHREjc – thank you George, the floor is yours 😊
January 30, 2026 at 4:02 PM
@gliperis.bsky.social will be the lead moderator of this #ESHREjc – thank you George, the floor is yours 😊
Reposted by Juan J. Fraire-Zamora
We’d also like to welcome our #ESHREjc experts
@paolavigano.bsky.social
@rvassena.bsky.social
@enricabianchi.bsky.social
AND authors Giovanni Coticchio and Danilo Cimadomo
@paolavigano.bsky.social
@rvassena.bsky.social
@enricabianchi.bsky.social
AND authors Giovanni Coticchio and Danilo Cimadomo
January 30, 2026 at 4:02 PM
We’d also like to welcome our #ESHREjc experts
@paolavigano.bsky.social
@rvassena.bsky.social
@enricabianchi.bsky.social
AND authors Giovanni Coticchio and Danilo Cimadomo
@paolavigano.bsky.social
@rvassena.bsky.social
@enricabianchi.bsky.social
AND authors Giovanni Coticchio and Danilo Cimadomo
Reposted by Juan J. Fraire-Zamora
Welcome to this month's #ESHREjc moderators 🙌 Have fun!
@gliperis.bsky.social
@noemisalmeri.bsky.social
@omarammar.bsky.social
@mr-att.bsky.social
@juanjo-fraire.bsky.social
@dkalaitzopoulos.bsky.social
@ribeirosara.bsky.social
@fabrizzio-horta.bsky.social
@gliperis.bsky.social
@noemisalmeri.bsky.social
@omarammar.bsky.social
@mr-att.bsky.social
@juanjo-fraire.bsky.social
@dkalaitzopoulos.bsky.social
@ribeirosara.bsky.social
@fabrizzio-horta.bsky.social
January 30, 2026 at 4:02 PM
Reposted by Juan J. Fraire-Zamora
For those who have not had the chance to read the paper our moderators have created a great Skytorial 👉 bsky.app/profile/glip...
#ESHREjc
#ESHREjc
January 30, 2026 at 4:02 PM
For those who have not had the chance to read the paper our moderators have created a great Skytorial 👉 bsky.app/profile/glip...
#ESHREjc
#ESHREjc
Reposted by Juan J. Fraire-Zamora
This edition’s paper is “The emerging role of the oocyte cortical domain in maturation, fertilization, and development” published in our academic journal Human Reproduction 👩🎓
🔗 doi.org/10.1093/humr...
#ESHREjc
🔗 doi.org/10.1093/humr...
#ESHREjc
The emerging role of the oocyte cortical domain in maturation, fertilization, and development
Abstract. The cell cortex, a cytoskeletal network with regulatory signalling pathways, is localized beneath the cell membrane: it is especially prominent i
doi.org
January 30, 2026 at 4:02 PM
This edition’s paper is “The emerging role of the oocyte cortical domain in maturation, fertilization, and development” published in our academic journal Human Reproduction 👩🎓
🔗 doi.org/10.1093/humr...
#ESHREjc
🔗 doi.org/10.1093/humr...
#ESHREjc
Almost there! #ESHREjc
Are you ready for the #ESHREjc? Starting in couple of hours, join the discussion on the versatile functions of the oocyte cortex over a 24h window! @rvassena.bsky.social @paolavigano.bsky.social @enricabianchi.bsky.social
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January 30, 2026 at 3:51 PM
Almost there! #ESHREjc
Reposted by Juan J. Fraire-Zamora
🔹 New FoR article online 🔹
A new Lancet series updates sexual & reproductive rights and universal access since the Guttmacher-Lancet report, calling on countries to tackle gaps and inequalities.
Read the entire article here 👇
www.focusonreproduction.eu/science-and-...
A new Lancet series updates sexual & reproductive rights and universal access since the Guttmacher-Lancet report, calling on countries to tackle gaps and inequalities.
Read the entire article here 👇
www.focusonreproduction.eu/science-and-...
January 29, 2026 at 8:00 AM
🔹 New FoR article online 🔹
A new Lancet series updates sexual & reproductive rights and universal access since the Guttmacher-Lancet report, calling on countries to tackle gaps and inequalities.
Read the entire article here 👇
www.focusonreproduction.eu/science-and-...
A new Lancet series updates sexual & reproductive rights and universal access since the Guttmacher-Lancet report, calling on countries to tackle gaps and inequalities.
Read the entire article here 👇
www.focusonreproduction.eu/science-and-...
Reposted by Juan J. Fraire-Zamora
@noemisalmeri.bsky.social @juanjo-fraire.bsky.social @omarammar.bsky.social @mr-att.bsky.social @ribeirosara.bsky.social @dkalaitzopoulos.bsky.social @fabrizzio-horta.bsky.social
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January 23, 2026 at 5:53 AM
Get ready for our next #ESHREjc in Bluesky! @eshre.bsky.social
🧬 The Oocyte Cortex: Fertility’s Hidden Control Layer
To find out join #ESHREjc on Friday 29/1 starting 17:00 CET.
@paolavigano.bsky.social @rvassena.bsky.social @enricabianchi.bsky.social&authors Giovanni Cotichio and Danilo Cimadomo
Paper ➡️ pubmed.ncbi.nlm.nih.gov/41206604/
🧵 #bluetorial 👇🏻
To find out join #ESHREjc on Friday 29/1 starting 17:00 CET.
@paolavigano.bsky.social @rvassena.bsky.social @enricabianchi.bsky.social&authors Giovanni Cotichio and Danilo Cimadomo
Paper ➡️ pubmed.ncbi.nlm.nih.gov/41206604/
🧵 #bluetorial 👇🏻
The emerging role of the oocyte cortical domain in maturation, fertilization, and development - PubMed
The cell cortex, a cytoskeletal network with regulatory signalling pathways, is localized beneath the cell membrane: it is especially prominent in mammalian oocytes. As in other cells, the cortex ensures appropriate shape and robustness of oocytes. It is also involved in other key and more specific …
pubmed.ncbi.nlm.nih.gov
January 23, 2026 at 6:18 AM
Get ready for our next #ESHREjc in Bluesky! @eshre.bsky.social
Reposted by Juan J. Fraire-Zamora
🌟 Conclusion
The oocyte cortex is a biomechanical decision-making layer controlling fertility, genome stability, and embryo survival and a powerful future tool for non-invasive IVF diagnostics. #ESHREjc
The oocyte cortex is a biomechanical decision-making layer controlling fertility, genome stability, and embryo survival and a powerful future tool for non-invasive IVF diagnostics. #ESHREjc
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January 23, 2026 at 5:53 AM
🌟 Conclusion
The oocyte cortex is a biomechanical decision-making layer controlling fertility, genome stability, and embryo survival and a powerful future tool for non-invasive IVF diagnostics. #ESHREjc
The oocyte cortex is a biomechanical decision-making layer controlling fertility, genome stability, and embryo survival and a powerful future tool for non-invasive IVF diagnostics. #ESHREjc
Reposted by Juan J. Fraire-Zamora
📊 IVF Insight
Mechanical tests show:
Cortical stiffness predicts blastulation better than morphology alone.
Biomechanics > embryologist grading
#ESHREjc
Mechanical tests show:
Cortical stiffness predicts blastulation better than morphology alone.
Biomechanics > embryologist grading
#ESHREjc
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ALT: two cats are standing next to each other on their hind legs and playing with each other .
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January 23, 2026 at 5:48 AM
📊 IVF Insight
Mechanical tests show:
Cortical stiffness predicts blastulation better than morphology alone.
Biomechanics > embryologist grading
#ESHREjc
Mechanical tests show:
Cortical stiffness predicts blastulation better than morphology alone.
Biomechanics > embryologist grading
#ESHREjc
Reposted by Juan J. Fraire-Zamora
🎯 Cortex Stiffness Tunes Chromosome Fidelity
Too stiff?
Too soft?
→ Both cause spindle failure and aneuploidy.
There is a narrow “Goldilocks zone.” #ESHREjc
Too stiff?
Too soft?
→ Both cause spindle failure and aneuploidy.
There is a narrow “Goldilocks zone.” #ESHREjc
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ALT: a cartoon character from the emperor 's new groove is giving a thumbs up sign .
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January 23, 2026 at 5:47 AM
🎯 Cortex Stiffness Tunes Chromosome Fidelity
Too stiff?
Too soft?
→ Both cause spindle failure and aneuploidy.
There is a narrow “Goldilocks zone.” #ESHREjc
Too stiff?
Too soft?
→ Both cause spindle failure and aneuploidy.
There is a narrow “Goldilocks zone.” #ESHREjc
Reposted by Juan J. Fraire-Zamora
⚡ Fyn Kinase = Cortical Master Regulator
Loss of Fyn → defective actin cortex, failed polar body extrusion, abnormal zona pellucida, chromosome errors → subfertility. #ESHREjc
Loss of Fyn → defective actin cortex, failed polar body extrusion, abnormal zona pellucida, chromosome errors → subfertility. #ESHREjc
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January 23, 2026 at 5:47 AM
⚡ Fyn Kinase = Cortical Master Regulator
Loss of Fyn → defective actin cortex, failed polar body extrusion, abnormal zona pellucida, chromosome errors → subfertility. #ESHREjc
Loss of Fyn → defective actin cortex, failed polar body extrusion, abnormal zona pellucida, chromosome errors → subfertility. #ESHREjc
Reposted by Juan J. Fraire-Zamora
🧱 Actomyosin Engineers the Cortex
ERM proteins+actin+myosin sculpt polarity, actin caps, and spindle migration.
Disruption = misalignment, meiotic arrest, aneuploidy.
#ESHREjc
ERM proteins+actin+myosin sculpt polarity, actin caps, and spindle migration.
Disruption = misalignment, meiotic arrest, aneuploidy.
#ESHREjc
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January 23, 2026 at 5:46 AM
🧱 Actomyosin Engineers the Cortex
ERM proteins+actin+myosin sculpt polarity, actin caps, and spindle migration.
Disruption = misalignment, meiotic arrest, aneuploidy.
#ESHREjc
ERM proteins+actin+myosin sculpt polarity, actin caps, and spindle migration.
Disruption = misalignment, meiotic arrest, aneuploidy.
#ESHREjc