A really nice 15 min talk on Scientific understanding by Henk de Regt. Really worth watching for those practicing scientists who like me haven't had the time to read his book yet www.youtube.com/watch?v=SY1v...

🚨 New preprint + thread 🧵
We've gone back to studying motoneuron control principles and their applications & here's paper #1:

A proof-of-concept study showing that people with tetraplegic spinal cord injury can control up to 2DoF from a single intramuscular implant

www.medrxiv.org/content/10.1...

🚨New paper🚨

Neural manifolds went from a niche-y word to an ubiquitous term in systems neuro thanks to many interesting findings across fields. But like with any emerging term, people use it very differently.

Here, we clarify our take on the term, and review key findings & challenges rdcu.be/ex8hW

Last week I attended the @bcisociety.bsky.social meeting for the first time; it was great fun! I enjoyed both catching up with friends and meeting new people, and re-thinking our comp neuro work and a bunch of other papers in the field in the context of BCI decoding
Two quick thoughts & 1 pic
1/4

Posting stuff while going through my reading list ... Here's a very well done study on mouse sensorimotor cortex from Matt Kaufman's lab. Not the first, but nice to see very careful characterization of mouse kinematics, and what features are reflected in M1 and S1

www.biorxiv.org/content/10.1...

I was thinking about this one in particular: www.americanscientist.org/sites/americ...

I was thinking of this figure, which suggests a coding "mechanism" at the population level

Always a pleasure :-)

For completeness, this is a plot comparing VMR in Parkinson's disease patients and controls (each plot is a different metric)

Quite a few… e.g., look at panel B from this great paper and compare II (adaptation to visuomotor rotation of the cursor feedback during centre out to 8 targets) to III -- deadaptation.

(Panel A is interesting: they told people that there was a rotation and they got it much faster, Panel C = A-B)

I am not sure the gatekeeping has become much harsher but it has gone up a bit (27.7% vs 31.4% pre- vs post-change)

Importantly, perceived quality and impact (thanks to assessments) hasn't shifted significantly

elifesciences.org/inside-elife...