James Conway
@jrwconway.bsky.social
Cancer researcher working in Finland
Lab website: https://www.helsinki.fi/en/researchgroups/tumour-microenvironment-and-metastasis
Lab website: https://www.helsinki.fi/en/researchgroups/tumour-microenvironment-and-metastasis
Hi! We find that replacement of endogenous integrin beta1 with a non-phosphorylatable mutant, reduces cancer invasion, and this was phenocopied by Shp2 inhibition in WT expressing cells (not in the mutant cells). It may be that Src & paxillin phosphorylation is also reduced in the mutant cells.
May 28, 2025 at 3:41 AM
Hi! We find that replacement of endogenous integrin beta1 with a non-phosphorylatable mutant, reduces cancer invasion, and this was phenocopied by Shp2 inhibition in WT expressing cells (not in the mutant cells). It may be that Src & paxillin phosphorylation is also reduced in the mutant cells.