Jakub Ruszkowski
@jruszkowski.bsky.social
MD, PhD. Internal medicine specialist, nephrology trainee. Passionate about pathophysiology, immunology, statistics, and evidence synthesis.
Normal anion gap metabolic acidosis + positive urine anion gap = RENAL TUBULAR ACIDOSIS
But which type? Proximal vs distal?🤔
Key findings that pointed to DISTAL RTA:
✅ Severe hypo-K
✅ Urine pH >5.5 despite systemic acidosis
✅ NO Fanconi syndrome features
www.kireportscommunity.org/post/renal-t...
But which type? Proximal vs distal?🤔
Key findings that pointed to DISTAL RTA:
✅ Severe hypo-K
✅ Urine pH >5.5 despite systemic acidosis
✅ NO Fanconi syndrome features
www.kireportscommunity.org/post/renal-t...
December 21, 2025 at 2:10 PM
Normal anion gap metabolic acidosis + positive urine anion gap = RENAL TUBULAR ACIDOSIS
But which type? Proximal vs distal?🤔
Key findings that pointed to DISTAL RTA:
✅ Severe hypo-K
✅ Urine pH >5.5 despite systemic acidosis
✅ NO Fanconi syndrome features
www.kireportscommunity.org/post/renal-t...
But which type? Proximal vs distal?🤔
Key findings that pointed to DISTAL RTA:
✅ Severe hypo-K
✅ Urine pH >5.5 despite systemic acidosis
✅ NO Fanconi syndrome features
www.kireportscommunity.org/post/renal-t...
Next level of cherry-picking. Lack of significance in Student's t-test? Report then F-test and interpret it as a t-test 🫣🫣🫣
(F-test compares variances, not means🤡)
Source: doi.org/10.3390/cell...
(F-test compares variances, not means🤡)
Source: doi.org/10.3390/cell...
July 1, 2025 at 6:29 PM
Next level of cherry-picking. Lack of significance in Student's t-test? Report then F-test and interpret it as a t-test 🫣🫣🫣
(F-test compares variances, not means🤡)
Source: doi.org/10.3390/cell...
(F-test compares variances, not means🤡)
Source: doi.org/10.3390/cell...
Sometimes it’s not about finding a disease marker — it’s about noticing what’s missing. In some cases, a healthy, stable microbiome is the best sign of health. When that pattern breaks, disease can follow.
doi.org/10.1101/2023...
doi.org/10.1101/2023...
May 7, 2025 at 4:39 PM
Sometimes it’s not about finding a disease marker — it’s about noticing what’s missing. In some cases, a healthy, stable microbiome is the best sign of health. When that pattern breaks, disease can follow.
doi.org/10.1101/2023...
doi.org/10.1101/2023...
2/4 Pathophysiology:
RHUC = mutations in proximal tubule UA transporters → impaired reabsorption → UA loss in urine. It can lead to exercise-induced AKI (EIAKI). To make life harder, during EIAKI, UA may normalize.
(Figure from www.mdpi.com/2227-9059/10...)
RHUC = mutations in proximal tubule UA transporters → impaired reabsorption → UA loss in urine. It can lead to exercise-induced AKI (EIAKI). To make life harder, during EIAKI, UA may normalize.
(Figure from www.mdpi.com/2227-9059/10...)
February 5, 2025 at 6:12 PM
2/4 Pathophysiology:
RHUC = mutations in proximal tubule UA transporters → impaired reabsorption → UA loss in urine. It can lead to exercise-induced AKI (EIAKI). To make life harder, during EIAKI, UA may normalize.
(Figure from www.mdpi.com/2227-9059/10...)
RHUC = mutations in proximal tubule UA transporters → impaired reabsorption → UA loss in urine. It can lead to exercise-induced AKI (EIAKI). To make life harder, during EIAKI, UA may normalize.
(Figure from www.mdpi.com/2227-9059/10...)
A great surprise to start the day—thank you, @wikipedia.org, for the recognition! 🥰
January 26, 2025 at 8:14 AM
A great surprise to start the day—thank you, @wikipedia.org, for the recognition! 🥰