John P. Overington
@jpoverington.bsky.social
Work at drughunter.com - Drug Discovery, Data Science, Cheminformatics, Computational Medicinal Chemistry, Drug Repositioning, Structural Bioinformatics, CADD, SaaS, DaaS, AI/ML https://scholar.google.com/citations?user=52VMFeYAAAAJ
Apparently it’s 48 years ago since New Boots and Panties was released. A true classic album, survived the test of time for sure!
September 30, 2025 at 9:57 PM
Apparently it’s 48 years ago since New Boots and Panties was released. A true classic album, survived the test of time for sure!
For self conscious pseudo-intellectual teenagers from post-industrial Britain in the 1980s this is big news. For the rest of the world - nothing to see here.
September 26, 2025 at 5:03 PM
For self conscious pseudo-intellectual teenagers from post-industrial Britain in the 1980s this is big news. For the rest of the world - nothing to see here.
Nostalgia ain’t what it used to be. Just found a microfiche. Big stack of these. If only I had the reader. I bet they’re museum pieces now.
September 7, 2025 at 7:20 PM
Nostalgia ain’t what it used to be. Just found a microfiche. Big stack of these. If only I had the reader. I bet they’re museum pieces now.
Just sorting through some old files.
Really fun to step back in time. This must have been 1988 or so. Acetates, permanent markers. None of your AI assistants in putting this together. And it shows 😂😂
Really fun to step back in time. This must have been 1988 or so. Acetates, permanent markers. None of your AI assistants in putting this together. And it shows 😂😂
September 7, 2025 at 7:13 PM
Just sorting through some old files.
Really fun to step back in time. This must have been 1988 or so. Acetates, permanent markers. None of your AI assistants in putting this together. And it shows 😂😂
Really fun to step back in time. This must have been 1988 or so. Acetates, permanent markers. None of your AI assistants in putting this together. And it shows 😂😂
It’s August in our home, and that means getting ready for Halloween!! The theme this year (apparently) is Labyrinth - here is David Bowie.
August 22, 2025 at 7:47 PM
It’s August in our home, and that means getting ready for Halloween!! The theme this year (apparently) is Labyrinth - here is David Bowie.
Getting frustrated with the number of resources that disappear, change terms of use, etc. Seems cheeky that people publish in places like NAR Database with an 'open' resource, then flip to closed. Tempted to put together a table of all the NAR DB resources and plot existence/current license....
August 5, 2025 at 3:55 PM
Getting frustrated with the number of resources that disappear, change terms of use, etc. Seems cheeky that people publish in places like NAR Database with an 'open' resource, then flip to closed. Tempted to put together a table of all the NAR DB resources and plot existence/current license....
And while I’m thinking of Nature, their typography has gone downhill. The spacing between words in titles is now atrocious! Defense against OCR LLM tokenization or just poor visual design? 🤣
July 20, 2025 at 6:07 PM
And while I’m thinking of Nature, their typography has gone downhill. The spacing between words in titles is now atrocious! Defense against OCR LLM tokenization or just poor visual design? 🤣
Bit of an insult for Nature magazine in the Google response to asking if fake patents and fake publications are different.
July 20, 2025 at 5:03 PM
Bit of an insult for Nature magazine in the Google response to asking if fake patents and fake publications are different.
UI oddity of the day - a box to ask if I'm human, which looks like the only option I have is to click to say no, turns out it's a slider hiding as a tick box.
July 1, 2025 at 11:10 AM
UI oddity of the day - a box to ask if I'm human, which looks like the only option I have is to click to say no, turns out it's a slider hiding as a tick box.
It’s my son’s birthday, so we are at a Metallica concert.
June 14, 2025 at 10:33 PM
It’s my son’s birthday, so we are at a Metallica concert.
A long day ahead, flying back home from Hamburg via Munich. Really enjoyed the CSSB 2025 conference, learnt so much; realised how much I missed virology.
May 9, 2025 at 4:16 AM
A long day ahead, flying back home from Hamburg via Munich. Really enjoyed the CSSB 2025 conference, learnt so much; realised how much I missed virology.
At DESY in Hamburg at CSSB for a few days. I’ll speak on structural biology and systems approaches in drug resistance, with a little splash of AI thrown in. I love these big science campuses.
May 7, 2025 at 7:02 AM
At DESY in Hamburg at CSSB for a few days. I’ll speak on structural biology and systems approaches in drug resistance, with a little splash of AI thrown in. I love these big science campuses.
I bought a really cute cactus today. Put it in plastic bag, then managed to enter glochid hell. Here is my hand with PVA glue waiting to dry.
May 2, 2025 at 11:50 PM
I bought a really cute cactus today. Put it in plastic bag, then managed to enter glochid hell. Here is my hand with PVA glue waiting to dry.
The approval of new differentiated drugs that improve on current therapies and particularly the approval of novel drugs for currently untreated diseases are the heartbeat of progress of the pharmaceutical industry and improved human health.
April 27, 2025 at 12:36 PM
The approval of new differentiated drugs that improve on current therapies and particularly the approval of novel drugs for currently untreated diseases are the heartbeat of progress of the pharmaceutical industry and improved human health.
At the finals of the First 2025 Championship Robot competition. It’s huge!
April 19, 2025 at 3:26 PM
At the finals of the First 2025 Championship Robot competition. It’s huge!
Just reading some old literature on penicillin and toxicity, there's a great turn of phrase I don't think can be beaten in the discussion of SAR - from watermark.silverchair.com/postgradmedj...
April 16, 2025 at 12:12 PM
Just reading some old literature on penicillin and toxicity, there's a great turn of phrase I don't think can be beaten in the discussion of SAR - from watermark.silverchair.com/postgradmedj...
My first home grown pineapple is coming along well. I had no idea there were flowers though.
April 12, 2025 at 7:43 PM
My first home grown pineapple is coming along well. I had no idea there were flowers though.
At a robot competition today with Albert. Great to see youngsters into STEM!
April 5, 2025 at 1:21 PM
At a robot competition today with Albert. Great to see youngsters into STEM!
Friday afternoon. Work this week was great fun. Time for a cheeky beer. Must admit I didn’t realise it was an 18.8%er.
March 21, 2025 at 9:00 PM
Friday afternoon. Work this week was great fun. Time for a cheeky beer. Must admit I didn’t realise it was an 18.8%er.
I love tracking the process and trends in drug discovery. Here is an interesting view of kinase inhibitors in development analyses by originator country. It is significant to see the growth of China as a very significant innovation centre for NMEs. Sorry that the countries.
March 4, 2025 at 5:48 PM
I love tracking the process and trends in drug discovery. Here is an interesting view of kinase inhibitors in development analyses by originator country. It is significant to see the growth of China as a very significant innovation centre for NMEs. Sorry that the countries.
Had a good find in a thrift store today while in Tomball this morning. 3 mint condition classic Tufte books for a total of 12 bucks.
March 1, 2025 at 9:57 PM
Had a good find in a thrift store today while in Tomball this morning. 3 mint condition classic Tufte books for a total of 12 bucks.
New work laptop. Don’t you love it when you have to adjust to a new keyboard and all that muscle memory is worthless.
February 17, 2025 at 3:56 PM
New work laptop. Don’t you love it when you have to adjust to a new keyboard and all that muscle memory is worthless.
The AI search agents out there are really bad. Here's an example from this morning that looked odd, so I checked. Turns out it's simply wrong. Do the search again on same computer and it's yet a different answer. Search engines should search, not guess in my view.
February 10, 2025 at 3:24 PM
The AI search agents out there are really bad. Here's an example from this morning that looked odd, so I checked. Turns out it's simply wrong. Do the search again on same computer and it's yet a different answer. Search engines should search, not guess in my view.