@josh-atkins.bsky.social
Had a great day out at the Royal Society of Chemistry in London for the CRUK "From Biology of Ageing to Cancer Prevention" Workshop - #CRUKPrevResearch! - Super cool room but I forgot to take photos
January 28, 2025 at 10:20 PM
Had a great day out at the Royal Society of Chemistry in London for the CRUK "From Biology of Ageing to Cancer Prevention" Workshop - #CRUKPrevResearch! - Super cool room but I forgot to take photos
Oxford really put on a show this morning in the -6 temperature
January 21, 2025 at 1:21 PM
Oxford really put on a show this morning in the -6 temperature
They do statistics different here in the UK
January 21, 2025 at 1:21 PM
They do statistics different here in the UK
Its great seeing how much the city i was born and raised in has progressed mostly thanks to this wonderful human. Make sure you vote @Nuatali_Nelmes so she can keep doing a fabulous job here in #Newcastle
January 21, 2025 at 1:21 PM
Its great seeing how much the city i was born and raised in has progressed mostly thanks to this wonderful human. Make sure you vote @Nuatali_Nelmes so she can keep doing a fabulous job here in #Newcastle
We found 4 proteins-cancer associations that had evidence from all analysis performed
January 21, 2025 at 1:59 PM
We found 4 proteins-cancer associations that had evidence from all analysis performed
Out of the 618 - we wanted to identify if there was any genetic evidence to support these associations -> We used cis-pQTL but also created exome scores (projected into the full ukbb exome data). We found strong evidence for one cis hit and 28 proteins using the exome-scores
January 21, 2025 at 1:53 PM
Out of the 618 - we wanted to identify if there was any genetic evidence to support these associations -> We used cis-pQTL but also created exome scores (projected into the full ukbb exome data). We found strong evidence for one cis hit and 28 proteins using the exome-scores
We identified 182 proteins that differed <3 years before diagnosis --> providing a potential marker for immediate cancer
January 21, 2025 at 1:43 PM
We identified 182 proteins that differed <3 years before diagnosis --> providing a potential marker for immediate cancer
when we stratified out into < 3 yrs to diagnosis, 3-7 yrs and > 7 yrs (median time do diagnosis in this group was 12 yrs). In the >7 yrs group we identified 107 protein-cancer associations.....
January 21, 2025 at 1:37 PM
when we stratified out into < 3 yrs to diagnosis, 3-7 yrs and > 7 yrs (median time do diagnosis in this group was 12 yrs). In the >7 yrs group we identified 107 protein-cancer associations.....
Using the invaluable @uk_biobank and the @OlinkProteomics data, we investigated 1,463 proteins across 19 common cancers, finding 618 protein-cancer associations.... (Thanks Trishna Desai for this great figure 1)
January 21, 2025 at 1:32 PM
Using the invaluable @uk_biobank and the @OlinkProteomics data, we investigated 1,463 proteins across 19 common cancers, finding 618 protein-cancer associations.... (Thanks Trishna Desai for this great figure 1)
My sister (aged 41) is terminal with metastatic breast cancer. I was told the Peter Mac was the best in Australia. Tried to get a second opinion to explore all treatment options here in Oz. No phone call. This is how the Peter Mac treats the most desperate cancer patients.
January 21, 2025 at 1:22 PM
My sister (aged 41) is terminal with metastatic breast cancer. I was told the Peter Mac was the best in Australia. Tried to get a second opinion to explore all treatment options here in Oz. No phone call. This is how the Peter Mac treats the most desperate cancer patients.
Here is what the updated UMAP for genetic ancestry looks like...
January 21, 2025 at 1:22 PM
Here is what the updated UMAP for genetic ancestry looks like...
We just had a very exciting unit seminar talk by @ellvlirae from the Genomic Epidemolgy Branch(GEM) at @IARCWHO on the largest GWAS results from the @HEADSpAcE_Study
January 21, 2025 at 1:27 PM
We just had a very exciting unit seminar talk by @ellvlirae from the Genomic Epidemolgy Branch(GEM) at @IARCWHO on the largest GWAS results from the @HEADSpAcE_Study
Strengthening the collaboration between @BristolUni , @IARCWHO and @UniofOxford for head and neck cancer research with @dudders1986, @DrShamaVirani and @ellvlirae
January 21, 2025 at 1:27 PM
Strengthening the collaboration between @BristolUni , @IARCWHO and @UniofOxford for head and neck cancer research with @dudders1986, @DrShamaVirani and @ellvlirae
When in Boston for meetings have to get a sneaky baseball game in... #lovemyjob
January 21, 2025 at 1:27 PM
When in Boston for meetings have to get a sneaky baseball game in... #lovemyjob
Hey Oxford Community.. someone broke into our garage and stole 2 bikes. If anyone has any info plz dm me. Would also love a share.. stolen from the house next to Botley McDonald's. The black bike is a giant defy advanced pro 2, and the blue is a specialized diverge e5
January 21, 2025 at 1:27 PM
Hey Oxford Community.. someone broke into our garage and stole 2 bikes. If anyone has any info plz dm me. Would also love a share.. stolen from the house next to Botley McDonald's. The black bike is a giant defy advanced pro 2, and the blue is a specialized diverge e5
Big day in unit, the Oxford component of the European Investigation into Cancer and Nutrition(EPIC) turned 30 today. Also celebrating the Feeding the future study (FEED) reaching 5000 participants.. 🥳🥳🥳🥳🥳🥳🥳🥳
January 21, 2025 at 1:27 PM
Big day in unit, the Oxford component of the European Investigation into Cancer and Nutrition(EPIC) turned 30 today. Also celebrating the Feeding the future study (FEED) reaching 5000 participants.. 🥳🥳🥳🥳🥳🥳🥳🥳
First week at @UniofOxford over. Amazed by all the great research and the talented individuals here ... Super pumped to do big things here
January 21, 2025 at 1:32 PM
First week at @UniofOxford over. Amazed by all the great research and the talented individuals here ... Super pumped to do big things here
Great to see the amazing work going on in my hometown in genomics.. great conference and well done to @williamreay96 @DKiltschewskij @duchatel_ryan
January 21, 2025 at 1:32 PM
Great to see the amazing work going on in my hometown in genomics.. great conference and well done to @williamreay96 @DKiltschewskij @duchatel_ryan
Today is my last day @IARCWHO. My top highlight was having my concept selected for the cover of Nature Genetics cheers mutographs team. Looking forward to my next big adventure at the @UniofOxford in the new year. But now, enjoying some downtime with my family back in Australia
January 21, 2025 at 1:32 PM
Today is my last day @IARCWHO. My top highlight was having my concept selected for the cover of Nature Genetics cheers mutographs team. Looking forward to my next big adventure at the @UniofOxford in the new year. But now, enjoying some downtime with my family back in Australia
This shows good evidence that smoking behaviours are influenced by the individual's germline genetics which influences their lifetime carcinogenic exposure -> increased somatic mutation burden
January 21, 2025 at 2:15 PM
This shows good evidence that smoking behaviours are influenced by the individual's germline genetics which influences their lifetime carcinogenic exposure -> increased somatic mutation burden
As expected for the CHRNA3-5 hit that we call Mr Big, the association was stronger and additional independent associations were discovered
January 21, 2025 at 1:59 PM
As expected for the CHRNA3-5 hit that we call Mr Big, the association was stronger and additional independent associations were discovered
Another novel finding is in 15q24 near CYP1A1 and CYP1A2 - This finding colocalises with lung function but not with SMOKING TRAITS - may be related to air pollution ????? - more work is need to explore this cool finding...
January 21, 2025 at 1:53 PM
Another novel finding is in 15q24 near CYP1A1 and CYP1A2 - This finding colocalises with lung function but not with SMOKING TRAITS - may be related to air pollution ????? - more work is need to explore this cool finding...
By meta-analysing these results, we have discovered an additional 8 new loci (coloured in red).......
January 21, 2025 at 1:43 PM
By meta-analysing these results, we have discovered an additional 8 new loci (coloured in red).......
We know that family history of lung cancer is a susceptibility factor - so we performed a genome-wide association by proxy (GWAx) within the @uk_biobank and compared this to the traditional GWAS approach using LC cases, the Manhattan plots are very similar ...
January 21, 2025 at 1:37 PM
We know that family history of lung cancer is a susceptibility factor - so we performed a genome-wide association by proxy (GWAx) within the @uk_biobank and compared this to the traditional GWAS approach using LC cases, the Manhattan plots are very similar ...
FYI - we broke it
January 21, 2025 at 1:37 PM
FYI - we broke it