Jordan Ray
@jordanray.bsky.social
Biology PhD Candidate at MIT studying lysosomal RNA degradation. UC Berkeley Alum
Pinned
Jordan Ray
@jordanray.bsky.social
· Sep 9
Lysosomal RNA profiling reveals targeting of specific types of RNAs for degradation
Autophagy targets a wide variety of substrates for degradation within lysosomes. While lysosomes are known to possess RNase activity, the role of lysosomal RNA degradation in post-transcriptional gene...
www.biorxiv.org
I am excited to share my graduate work in the Sabatini and @bartellab.bsky.social labs. Since their discovery, we have known lysosomes possess RNase activity; however, their substrates were not known. Surprisingly we find specific RNAs are targeted for degradation! www.biorxiv.org/content/10.1...
Reposted by Jordan Ray
Check out the latest work from our lab, led by Daniel Lin and Lara Elcavage: www.biorxiv.org/content/10.1... (1/3)
mRNA 3′ UTRs direct microRNA degradation to participate in imprinted gene networks and regulate growth
MicroRNAs direct downregulation of target mRNAs. Sometimes, however, this regulatory paradigm inverts, and a target RNA triggers the degradation of a microRNA. This target-directed microRNA degradatio...
www.biorxiv.org
November 7, 2025 at 6:33 PM
Check out the latest work from our lab, led by Daniel Lin and Lara Elcavage: www.biorxiv.org/content/10.1... (1/3)
Reposted by Jordan Ray
Check out the latest work from our lab, led by Arash Latifkar @ara-latifkar.bsky.social , www.biorxiv.org/content/10.1...
mRNA poly(A)-tail length is a battleground for coronavirus–host competition
Most eukaryotic mRNAs contain a poly(A) tail, which in post-embryonic cells enhances their stability. Many cytoplasmic RNA viruses also harbor poly(A) tails on their genomic RNA and mRNAs. Here, we re...
www.biorxiv.org
October 13, 2025 at 7:44 PM
Check out the latest work from our lab, led by Arash Latifkar @ara-latifkar.bsky.social , www.biorxiv.org/content/10.1...
Reposted by Jordan Ray
Check out the latest work from Jordan Ray (@jordanray.bsky.social), a collaboration between our lab and David Sabatini’s lab. www.biorxiv.org/content/10.1... (1/2)
Lysosomal RNA profiling reveals targeting of specific types of RNAs for degradation
Autophagy targets a wide variety of substrates for degradation within lysosomes. While lysosomes are known to possess RNase activity, the role of lysosomal RNA degradation in post-transcriptional gene...
www.biorxiv.org
September 11, 2025 at 1:58 PM
Check out the latest work from Jordan Ray (@jordanray.bsky.social), a collaboration between our lab and David Sabatini’s lab. www.biorxiv.org/content/10.1... (1/2)
I am excited to share my graduate work in the Sabatini and @bartellab.bsky.social labs. Since their discovery, we have known lysosomes possess RNase activity; however, their substrates were not known. Surprisingly we find specific RNAs are targeted for degradation! www.biorxiv.org/content/10.1...
Lysosomal RNA profiling reveals targeting of specific types of RNAs for degradation
Autophagy targets a wide variety of substrates for degradation within lysosomes. While lysosomes are known to possess RNase activity, the role of lysosomal RNA degradation in post-transcriptional gene...
www.biorxiv.org
September 9, 2025 at 9:53 PM
I am excited to share my graduate work in the Sabatini and @bartellab.bsky.social labs. Since their discovery, we have known lysosomes possess RNase activity; however, their substrates were not known. Surprisingly we find specific RNAs are targeted for degradation! www.biorxiv.org/content/10.1...
Reposted by Jordan Ray
Are u tired of reading about tariffs? Then take a look to our last work! @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Retromer promotes the lysosomal turnover of mtDNA
Lysosomal uptake of mtDNA controls mitochondrial quality.
www.science.org
April 4, 2025 at 6:07 PM
Are u tired of reading about tariffs? Then take a look to our last work! @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Very cool. www.science.org/doi/10.1126/...
Exogenous RNA surveillance by proton-sensing TRIM25
Exogenous messenger RNAs (mRNAs) require cellular machinery for delivery and translation but also encounter inhibitory factors. To investigate their regulation, we performed genome-wide CRISPR screens...
www.science.org
April 5, 2025 at 8:02 PM
Very cool. www.science.org/doi/10.1126/...
Reposted by Jordan Ray
Don’t miss this Q&A with Dr. Michelle Frank (@michelle-frank.bsky.social), an awesome postdoc in our lab!
Our latest Postdoc Q&A features Michelle Frank from the Bartel lab. Michelle is interested in how the brain balances the ability to learn new things with the need for maintaining stable connections. wi.mit.edu/news/meet-wh... #WhiteheadPostdocProfiles @bartellab.bsky.social
April 5, 2025 at 7:51 PM
Don’t miss this Q&A with Dr. Michelle Frank (@michelle-frank.bsky.social), an awesome postdoc in our lab!
🫣
March 30, 2025 at 8:05 AM
🫣
Reposted by Jordan Ray
Pleased to share my recent work from the Bartel Lab! Some miRNAs recognize novel target sites called 3'-only sites, which pair to the miRNA 3' region but not to the seed. These sites direct mRNA repression in cells and are engaged by different mechanisms to seed sites
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Functional microRNA targeting without seed pairing
MicroRNAs (miRNAs) associate with Argonaute (AGO) proteins to serve as guides, directing binding to partially complementary sites in mRNAs, ultimately causing post-transcriptional repression. Compleme...
www.biorxiv.org
March 12, 2025 at 9:57 PM
Pleased to share my recent work from the Bartel Lab! Some miRNAs recognize novel target sites called 3'-only sites, which pair to the miRNA 3' region but not to the seed. These sites direct mRNA repression in cells and are engaged by different mechanisms to seed sites
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Jordan Ray
We’ve preprinted a small follow-up to our identification of MFSD12 as a mediator of lysosomal cysteine import. Would love to discuss, so please get in contact if you have comments or suggestions!
Lysosomal reduced thiols are essential for mouse embryonic development https://www.biorxiv.org/content/10.1101/2024.12.26.630348v1
December 27, 2024 at 8:55 PM
We’ve preprinted a small follow-up to our identification of MFSD12 as a mediator of lysosomal cysteine import. Would love to discuss, so please get in contact if you have comments or suggestions!
Reposted by Jordan Ray
Bartel Lab bids a fond farewell to our incredible lab manager, Asia Stefano. Wishing you all the best on your new adventures in the Rocky Mountains, Asia—thank you for the amazing time we shared together!
December 18, 2024 at 10:24 PM
Bartel Lab bids a fond farewell to our incredible lab manager, Asia Stefano. Wishing you all the best on your new adventures in the Rocky Mountains, Asia—thank you for the amazing time we shared together!
Reposted by Jordan Ray
If you've been meaning to check out the Night Science Podcast, this is the perfect episode to get started with. Everyone is telling me it's our best one yet!
November 27, 2024 at 10:54 PM
If you've been meaning to check out the Night Science Podcast, this is the perfect episode to get started with. Everyone is telling me it's our best one yet!
www.cell.com/cell/fulltex...
Quite a cool novel role for a snoRNA. I am curious how the structured domain of the SRP RNA becomes accessible for snoRNA73 binding and if this would disrupt SRP19 binding to the SRP RNA.
Quite a cool novel role for a snoRNA. I am curious how the structured domain of the SRP RNA becomes accessible for snoRNA73 binding and if this would disrupt SRP19 binding to the SRP RNA.
snoRNA-facilitated protein secretion revealed by transcriptome-wide snoRNA target identification
Transcriptome-wide mapping of snoRNA targets reveals mRNA-snoRNA-7SL RNA ternary interactions,
which facilitate nascent protein translocation to the ER and subsequent secretion.
www.cell.com
November 27, 2024 at 8:16 PM
www.cell.com/cell/fulltex...
Quite a cool novel role for a snoRNA. I am curious how the structured domain of the SRP RNA becomes accessible for snoRNA73 binding and if this would disrupt SRP19 binding to the SRP RNA.
Quite a cool novel role for a snoRNA. I am curious how the structured domain of the SRP RNA becomes accessible for snoRNA73 binding and if this would disrupt SRP19 binding to the SRP RNA.