Real-world example on how targeted protein sequence engineering can significantly outperform structurally informed de novo design. I strongly believe both methods have their place. This challenge by #AdaptyvBio was a good example of optimization>design.

www.cradle.bio/blog/adaptyv...

Adaptyv Bio hosted an antibody engineering competition to design/engineer binders to EGFR. Super stoked that we came in first place with the Cradle team! We’ll be talking about the methods used at #NeurIPS this coming week!
Here are the full results

foundry.adaptyvbio.com/competition