Jonathan Haars
@jonathanhaars.bsky.social
PhD-student in clinical microbiology at Uppsala University and Uppsala University Hospital, Sweden.
Interested in Nanopore sequencing, metagenomics, SARS-CoV-2 and more.
Interested in Nanopore sequencing, metagenomics, SARS-CoV-2 and more.
Link to the original research article: www.tandfonline.com/doi/full/10.... 🧪
Dynamics of SARS-CoV-2 variants and mutations in Central Sweden between 2023 and 2024 and their potential implications on monoclonal antibodies pemivibart and sipavibart as PrEP in the region
Monoclonal antibodies (mAbs) are an important option against SARS-CoV-2, especially as pre-exposure prophylaxis (PrEP) for patients with immune system impairment. PrEP mAbs like sipavibart and pemi...
www.tandfonline.com
June 9, 2025 at 12:57 PM
Link to the original research article: www.tandfonline.com/doi/full/10.... 🧪
Karin Elfving, Anna-Karin Jonsson and Hong Yin from @RegionDalarna, Patrik Ellström, Johan Lindh and René Kaden from the Department of Medical Sciences at Uppsala University and Uppsala University Hospital.
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May 29, 2025 at 9:39 PM
Karin Elfving, Anna-Karin Jonsson and Hong Yin from @RegionDalarna, Patrik Ellström, Johan Lindh and René Kaden from the Department of Medical Sciences at Uppsala University and Uppsala University Hospital.
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The manuscript was written together with my co-supervisor Johan Lennerstrand and co-authors Navaneethan Palanisamy from Chester Medical School, Frans Wallin, Paula Mölling and Martin Sundqvist from Örebro University, and…
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May 29, 2025 at 9:37 PM
The manuscript was written together with my co-supervisor Johan Lennerstrand and co-authors Navaneethan Palanisamy from Chester Medical School, Frans Wallin, Paula Mölling and Martin Sundqvist from Örebro University, and…
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The threat to global health by SARS-CoV-2, Covid-19 and long covid is not over. Continual surveillance through sequencing is needed to understand the dynamics of its spread and evolution.
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May 29, 2025 at 9:36 PM
The threat to global health by SARS-CoV-2, Covid-19 and long covid is not over. Continual surveillance through sequencing is needed to understand the dynamics of its spread and evolution.
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This highlights the importance of rapidly developing, testing and approving new drugs for viruses undergoing relatively rapid evolution, such as SARS-CoV-2 because of its large global spread.
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May 29, 2025 at 9:36 PM
This highlights the importance of rapidly developing, testing and approving new drugs for viruses undergoing relatively rapid evolution, such as SARS-CoV-2 because of its large global spread.
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We found that the lineages and mutations causing resistance became more common during the study period. Meaning these monoclonal antibodies may be less useful than initially thought.
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May 29, 2025 at 9:36 PM
We found that the lineages and mutations causing resistance became more common during the study period. Meaning these monoclonal antibodies may be less useful than initially thought.
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Among these drugs are the monoclonal antibodies. Which are very important to some of the most vulnerable people in society, the immunocompromised. We investigated how common the SARS-COV-2 lineages and mutations which offer resistance were in central Sweden in 2023 and 2024
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May 29, 2025 at 9:35 PM
Among these drugs are the monoclonal antibodies. Which are very important to some of the most vulnerable people in society, the immunocompromised. We investigated how common the SARS-COV-2 lineages and mutations which offer resistance were in central Sweden in 2023 and 2024
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Whole genome sequencing allows tracking mutations and how their abundance changes over time. These are important, they are responsible for how the virus spreads, for how the virus evades the immune system, and are also responsible for causing resistance against drugs.
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May 29, 2025 at 9:34 PM
Whole genome sequencing allows tracking mutations and how their abundance changes over time. These are important, they are responsible for how the virus spreads, for how the virus evades the immune system, and are also responsible for causing resistance against drugs.
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This has helped us track which variants of the virus are present in the population at different times. Waves of different variants come and go, spreading from one continent to the next.
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May 29, 2025 at 9:33 PM
This has helped us track which variants of the virus are present in the population at different times. Waves of different variants come and go, spreading from one continent to the next.
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In a collaboration between Region Uppsala, Region Dalarna and Region Örebro we nanopore sequenced SARS-CoV-2 to track resistance mutations affecting monoclonal antibodies pemivibart and sipavibart #COVID19 treatments.
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May 29, 2025 at 9:32 PM
In a collaboration between Region Uppsala, Region Dalarna and Region Örebro we nanopore sequenced SARS-CoV-2 to track resistance mutations affecting monoclonal antibodies pemivibart and sipavibart #COVID19 treatments.
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Reposted by Jonathan Haars
May 18, 2025 at 11:29 PM