Poster today #161

Sometimes I can't find it anywhere in the paper!

This! Looking at my summer of deadlines whilst juggling childcare...😭

I feel seen 👀

Thought this for a while...they kill the vibe

I've added you to the synapse starter pack...welcome!

very cool, congrats!

Would be happy to help review

I seem to do all major work and life events together too...or maybe that's just adulting

Thanks for being such an awesome colleague! We will miss you but exciting times ahead for you!

This opens up new synaptic tragets and avenues for the therapeutic targeting of synapses in AD. This was a great team effort by Jessica Griffiths joint with Seth Grant lab, Eleonore Scheegans and the UKDRI MAP team. The end. 6/6

Taken together, we believe we have derived a pseudotemporal profile of synaptic changes in human AD and shown that they are associated with changes in the astrocyte proteome, particularly that of PAPs. 5/6

Alongside these synaptic changes, we found a astrcoyte signature that was enriched for proteins at the peri-synaptic astrocytic processes (PAPs). This astrocyte signature increased with pathology and was associated with reduced synaptic resilience. 4/6

Mitochondrial proteomic changes dominated in the low pathology region, inhibitory changes in the mid pathology region and widespread synaptic transmission pathways were most prominant in the higher pathology region. 3/6