John Stinchcombe
@johnstinchcombe.bsky.social
Ecological and evolutionary genetics in Ecology and Evolutionary Biology at UofT. Dad, dog lover, unashamed coffee addict.
A stunning day to be in the field in Southern Ontario today, at the Koffler Scientific Reserve, @ksrjokershill.bsky.social
September 18, 2025 at 1:46 AM
A stunning day to be in the field in Southern Ontario today, at the Koffler Scientific Reserve, @ksrjokershill.bsky.social
Congrats to Dr. Meng Yuan, who defended her PhD on the genome-wide potential for ploidy & sexual conflict in plants! Many thanks to @judithmank.bsky.social for serving as her external examiner. A fun collaboration w/ @stepheniwright.bsky.social and also @stuartmcdaniel.bsky.social for a paper!
September 16, 2025 at 2:47 AM
Congrats to Dr. Meng Yuan, who defended her PhD on the genome-wide potential for ploidy & sexual conflict in plants! Many thanks to @judithmank.bsky.social for serving as her external examiner. A fun collaboration w/ @stepheniwright.bsky.social and also @stuartmcdaniel.bsky.social for a paper!
Prettiest view on campus! @utoronto.ca
July 10, 2025 at 6:02 PM
Prettiest view on campus! @utoronto.ca
What we all wish we could say to reviewer 2, or overly aggressive conference questions.
April 30, 2025 at 4:28 PM
What we all wish we could say to reviewer 2, or overly aggressive conference questions.
I don't know..... I look at Figure 2 in the paper-- not the news and views summary-- and I see a lot more Mendelian variation than quantitative genetic variation.
This snap shot of Figure 2 looks like the old-fashioned Punnett square still works.....
This snap shot of Figure 2 looks like the old-fashioned Punnett square still works.....
April 23, 2025 at 6:01 PM
I don't know..... I look at Figure 2 in the paper-- not the news and views summary-- and I see a lot more Mendelian variation than quantitative genetic variation.
This snap shot of Figure 2 looks like the old-fashioned Punnett square still works.....
This snap shot of Figure 2 looks like the old-fashioned Punnett square still works.....
She then used Principal Component regression to estimate selection accounting for the correlated expression of other genes.
We found appreciable selection, centered around zero. Perhaps not surprisingly, selection on the expression of individual genes is much weaker than on macro phenotypes.
We found appreciable selection, centered around zero. Perhaps not surprisingly, selection on the expression of individual genes is much weaker than on macro phenotypes.
March 25, 2025 at 1:00 PM
She then used Principal Component regression to estimate selection accounting for the correlated expression of other genes.
We found appreciable selection, centered around zero. Perhaps not surprisingly, selection on the expression of individual genes is much weaker than on macro phenotypes.
We found appreciable selection, centered around zero. Perhaps not surprisingly, selection on the expression of individual genes is much weaker than on macro phenotypes.
To measure selection on expression, for each gene she estimated selection differentials. Mean expression of those that reproduced minus mean expression of the entire population.
At manageable sample sizes, she detected phenotypic expression to increase & decrease gene expression.
At manageable sample sizes, she detected phenotypic expression to increase & decrease gene expression.
March 25, 2025 at 1:00 PM
To measure selection on expression, for each gene she estimated selection differentials. Mean expression of those that reproduced minus mean expression of the entire population.
At manageable sample sizes, she detected phenotypic expression to increase & decrease gene expression.
At manageable sample sizes, she detected phenotypic expression to increase & decrease gene expression.
She grew ~ 100 individuals of Ipomoea hederacea at our field station, the Koffler Scientific Reserve. At the midpoint of their life cycle, she gathered leaf tissue for RNAseq. At the end of the season, she scored fitness components: those that reproduced successfully, & seed set, given reproduction.
March 25, 2025 at 1:00 PM
She grew ~ 100 individuals of Ipomoea hederacea at our field station, the Koffler Scientific Reserve. At the midpoint of their life cycle, she gathered leaf tissue for RNAseq. At the end of the season, she scored fitness components: those that reproduced successfully, & seed set, given reproduction.
Interested in gene expression, machine learning, natural selection, and evolution? My former student, Georgia Henry just published a paper that may interest you.
Her goal: understand how natural selection acts on the transcriptome, within a single generation experiment, *in the field*.
Her goal: understand how natural selection acts on the transcriptome, within a single generation experiment, *in the field*.
March 25, 2025 at 1:00 PM
Interested in gene expression, machine learning, natural selection, and evolution? My former student, Georgia Henry just published a paper that may interest you.
Her goal: understand how natural selection acts on the transcriptome, within a single generation experiment, *in the field*.
Her goal: understand how natural selection acts on the transcriptome, within a single generation experiment, *in the field*.
Post a warning.
March 24, 2025 at 5:39 PM
Post a warning.
I am interested in recruiting PhD students in the area of plant ecological genetics!
Potential topics include ecological genomics in Arabidopsis, morning glory, or ragweed; plant-microbe interactions; or new topics at the intersection of quant gen and pop gen.
Application portal opens Nov 1.
Potential topics include ecological genomics in Arabidopsis, morning glory, or ragweed; plant-microbe interactions; or new topics at the intersection of quant gen and pop gen.
Application portal opens Nov 1.
October 31, 2024 at 8:31 PM
I am interested in recruiting PhD students in the area of plant ecological genetics!
Potential topics include ecological genomics in Arabidopsis, morning glory, or ragweed; plant-microbe interactions; or new topics at the intersection of quant gen and pop gen.
Application portal opens Nov 1.
Potential topics include ecological genomics in Arabidopsis, morning glory, or ragweed; plant-microbe interactions; or new topics at the intersection of quant gen and pop gen.
Application portal opens Nov 1.
While I'm sad to miss #Evol2024, two grad students from my lab will be there to present their PhD work: Amanda Peake (@GWAS_Peake on the other place) and Meng Yuan (@imengyuan on the bird site) who I coadvise with
@stepheniwright.bsky.social ! Please say hello and check out their work!
@stepheniwright.bsky.social ! Please say hello and check out their work!
July 26, 2024 at 5:27 PM
While I'm sad to miss #Evol2024, two grad students from my lab will be there to present their PhD work: Amanda Peake (@GWAS_Peake on the other place) and Meng Yuan (@imengyuan on the bird site) who I coadvise with
@stepheniwright.bsky.social ! Please say hello and check out their work!
@stepheniwright.bsky.social ! Please say hello and check out their work!
First day of class, and we're off !
January 9, 2024 at 7:52 PM
First day of class, and we're off !
Hi! I'm John Stinchcombe (EEB, UToronto). I'm looking to recruit PhD students to work on plant ecological genetics. We blend field work, greenhouse experiments, & genetics.
(Like @flybehaviour.bsky.social I’m in Canada, which has nationalized healthcare, bodily autonomy for women, & gun control).
(Like @flybehaviour.bsky.social I’m in Canada, which has nationalized healthcare, bodily autonomy for women, & gun control).
October 4, 2023 at 1:59 PM
Hi! I'm John Stinchcombe (EEB, UToronto). I'm looking to recruit PhD students to work on plant ecological genetics. We blend field work, greenhouse experiments, & genetics.
(Like @flybehaviour.bsky.social I’m in Canada, which has nationalized healthcare, bodily autonomy for women, & gun control).
(Like @flybehaviour.bsky.social I’m in Canada, which has nationalized healthcare, bodily autonomy for women, & gun control).
Also looks about bang-on for me.
September 23, 2023 at 6:45 AM
Also looks about bang-on for me.
1 week in the books @SCAS_Uppsala! Still settling in, and trying to enjoy the tail end of summer.
September 11, 2023 at 4:06 PM
1 week in the books @SCAS_Uppsala! Still settling in, and trying to enjoy the tail end of summer.
This stuff is remarkably good. Surprisingly, because it came from a foil pouch like a Capri Sun.
August 22, 2023 at 6:49 PM
This stuff is remarkably good. Surprisingly, because it came from a foil pouch like a Capri Sun.