John Helmann
@johnhelmann.bsky.social
Professor at Cornell Univ. Bacillus subtilis physiology and stress responses (metal homeostasis, redox stress, antibiotic resistance & cell envelope). EIC of Mol Microbiol.
The B. subtilis histidine-containing phosphocarrier protein (HPr) supports PTS-sugar import, interacts with GAPDH, and helps mediate carbon catabolite repression (CCR). Here, a mutant HPr protein is shown to alleviate metabolic intoxication in a cpgA mutant.
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
August 14, 2025 at 2:09 PM
The B. subtilis histidine-containing phosphocarrier protein (HPr) supports PTS-sugar import, interacts with GAPDH, and helps mediate carbon catabolite repression (CCR). Here, a mutant HPr protein is shown to alleviate metabolic intoxication in a cpgA mutant.
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
A new paper led by Ahmed Gaballa and Yesha Patel explores the pathways that reduce the dithiolopyrrolone (DTP) antibiotic thiolutin in B. subtilis. The active dithiol chelates intracellular Zn ions to impede growth.
#MicroSky #Zinc #Antibiotics
journals.asm.org/doi/10.1128/...
#MicroSky #Zinc #Antibiotics
journals.asm.org/doi/10.1128/...
July 3, 2025 at 3:50 PM
A new paper led by Ahmed Gaballa and Yesha Patel explores the pathways that reduce the dithiolopyrrolone (DTP) antibiotic thiolutin in B. subtilis. The active dithiol chelates intracellular Zn ions to impede growth.
#MicroSky #Zinc #Antibiotics
journals.asm.org/doi/10.1128/...
#MicroSky #Zinc #Antibiotics
journals.asm.org/doi/10.1128/...
This new cryoEM structure can be viewed in the context of results published previously by Huang et al.
onlinelibrary.wiley.com/doi/10.1111/...
MntR represses uptake genes (mntH, mntA) and activates efflux genes (mneP/S). The latter occurs with higher Mn and with higher cooperativity.
#MicroSky
onlinelibrary.wiley.com/doi/10.1111/...
MntR represses uptake genes (mntH, mntA) and activates efflux genes (mneP/S). The latter occurs with higher Mn and with higher cooperativity.
#MicroSky
March 5, 2025 at 3:53 PM
This new cryoEM structure can be viewed in the context of results published previously by Huang et al.
onlinelibrary.wiley.com/doi/10.1111/...
MntR represses uptake genes (mntH, mntA) and activates efflux genes (mneP/S). The latter occurs with higher Mn and with higher cooperativity.
#MicroSky
onlinelibrary.wiley.com/doi/10.1111/...
MntR represses uptake genes (mntH, mntA) and activates efflux genes (mneP/S). The latter occurs with higher Mn and with higher cooperativity.
#MicroSky
Want to hear some great talks about Bacterial Locomotion and Signal Transduction?
The BLAST conference (Jan. 19-24) has a "virtual" option this year (for a nominal fee). More than 50 talks and 100 posters!
blastscience.regfox.com/blast-xviii-... Registration deadline is Friday, Jan 10!
The BLAST conference (Jan. 19-24) has a "virtual" option this year (for a nominal fee). More than 50 talks and 100 posters!
blastscience.regfox.com/blast-xviii-... Registration deadline is Friday, Jan 10!
January 6, 2025 at 3:18 PM
Want to hear some great talks about Bacterial Locomotion and Signal Transduction?
The BLAST conference (Jan. 19-24) has a "virtual" option this year (for a nominal fee). More than 50 talks and 100 posters!
blastscience.regfox.com/blast-xviii-... Registration deadline is Friday, Jan 10!
The BLAST conference (Jan. 19-24) has a "virtual" option this year (for a nominal fee). More than 50 talks and 100 posters!
blastscience.regfox.com/blast-xviii-... Registration deadline is Friday, Jan 10!