Thank you for your kind comments. And congratulations on your 2022 Nature Metabolism discovery on astrocyte-neuron ketone shuttle www.nature.com/articles/s42...!

Good question. If you read how that view came to be, it’s from studies e.g. using isolated mitochondria (excluding neuronal and Ddhd2 activity), supplementing short-chain fatty acids, or by comparing beta-ox capacity to cells with robust beta-ox such as astocytes or cardiomyocytes.

🎉 Our discovery opens up exciting new research avenues for supporting healthy brain aging, and treating other metabolic brain disorders. 3/3 #raredisease #mitochondria #neuronalenergy #fattyacids #beta-oxidation #HSP #SPG #metabolism #lipids

💊 Loss of DDHD2-fatty acid pathway causes hereditary spastic paraplegia (HSP54), a childhood-onset neurodegenerative disorder. Excitingly, we found that a combination of activated fatty acids restored neuronal energy and function in HSP54-model neurons, identifying a potential therapy for HSP54. 2/3

Out study suggests that dynamin function at endocytic pits can be essential for infection with single-receptor viruses, while it is not essential but increases uptake and infection efficiency of multi-receptor viruses that otherwise rely on a functional actin network for infection.

Could you please add me to this list? :)

Could you please add me? My lab does all things microscopy 😊

Please add me too