This remark is especially on-point for structural biologists lately. Augmentation is always enshittification to some degree, especially when extrapolated out to several orders of magnitude beyond simulation limits of a model full of dubious assumptions to begin with. E.g: bsky.app/profile/fran...

Water networks in xtal structures is something I have been analyzing extensively, but until I saw your post I hadn’t looked at cryoEM. May I ask what temperature was used? Network size goes up linearly with decreasing T. My DMs are open.