Leveraging proprietary AI and ML approaches, our researchers have discovered a broad range of human proteins potentially accessible to cereblon (CRBN)-based degradation, spanning diverse protein domains and classes, including many targets historically considered undruggable.

Proud to share this new preprint from our team at Monte Rosa. By integrating AI with computational design and structural biology, we're mapping the features that make a protein degradable – what we call ‘glueprints’ – expanding what’s possible with molecular glue degraders.