We tend to forget that most expressed genes are actively transcribes only a few times per day…. Explains why E-P interactions seems so infrequent when analyzed by bulk assays . This study is very insightful.

Important result!

Yes, great work! And important work from @wbickmor.bsky.social

It is certainly en voque to make such claims. Many genes may simply not need very distant enhancers. But those that do (often key developmental genes) usually depend on appropriate chromosome looping, and these interaction follow the logic of loop extrusion plus CTCF blocking