Josca Schoonejans, PhD
@jmschoonejans.bsky.social
Interested in adipose tissue, metabolic disorders of pregnancy & developmental origins of health and disease (DOHaD) | Imperial College London | UK, NL | Imperial College Research Fellow at the MRC-LMS
See our paper here
Recently I moved from offspring to maternal health, studying the role of bile acids in pathogenesis of human GDM. I found serum bile acids are associated with insulin resistance, and increased in GDM in European (but not in South Asian) women: obgyn.onlinelibrary.wiley.com/doi/10.1111/...
OBGYN
Objective
Investigation of serum bile acid profiles in pregnancies complicated by gestational diabetes mellitus (GDM) in a multi-ethnic cohort of women who are lean or obese.
Design
Prospective co.....
obgyn.onlinelibrary.wiley.com
October 2, 2025 at 1:31 PM
See our paper here
New paper update! bsky.app/profile/jmsc...
Our new paper showing sex-specific adverse #cardiovascular outcomes of prenatal #metformin exposure in a mouse model of diet-induced glucose intolerance is out now in @jphysiol.bsky.social ! 🐁❤️ ♂️♀ Find it here shorturl.at/VKqjD (in collab with @ozannelab.bsky.social & Giussani labs) #DOHaD
July 18, 2025 at 10:46 AM
New paper update! bsky.app/profile/jmsc...
Our new paper showing sex-specific adverse #cardiovascular outcomes of prenatal #metformin exposure in a mouse model of diet-induced glucose intolerance is out now in @jphysiol.bsky.social ! 🐁❤️ ♂️♀ Find it here shorturl.at/VKqjD (in collab with @ozannelab.bsky.social & Giussani labs) #DOHaD
July 17, 2025 at 4:31 PM
Full paper here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
Cardiovascular outcome in 12‐month‐old male and female offspring of metformin‐treated obese mice
Abstract figure legend This study described the effects of exposure to maternal obesogenic diet and metformin treatment during pregnancy on offspring cardiovascular outcomes. Maternal diet-induced ob...
physoc.onlinelibrary.wiley.com
June 23, 2025 at 3:14 PM
Full paper here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
This highlights the need for long-term cardiovascular follow up in offspring (of both sexes!) from human metformin-treated pregnancies to inform decisions about its use in pregnancy - a tricky question that requires balancing mum and baby's health 👩🍼
June 23, 2025 at 3:14 PM
This highlights the need for long-term cardiovascular follow up in offspring (of both sexes!) from human metformin-treated pregnancies to inform decisions about its use in pregnancy - a tricky question that requires balancing mum and baby's health 👩🍼
Offspring of obese mice had hypertension and diastolic dysfunction by 12mo. Maternal #metformin worsened the phenotype and introduced sex-dependent CV alterations in both male (cardiac stiffening, vascular dysfunction) & female (obesity-induced hypertension) offspring.
June 23, 2025 at 3:14 PM
Offspring of obese mice had hypertension and diastolic dysfunction by 12mo. Maternal #metformin worsened the phenotype and introduced sex-dependent CV alterations in both male (cardiac stiffening, vascular dysfunction) & female (obesity-induced hypertension) offspring.
Career development update / an example of an exciting project announced this month! bsky.app/profile/jmsc...
I'm thrilled to finally announce that I have been awarded an Imperial College Research Fellowship! I am excited to join @mrc-lms.bsky.social later in 2025 to study novel treatments for gestational diabetes and start my career as an independent researcher🥂 @imperialcollegeldn.bsky.social #GDM #DOHaD
February 26, 2025 at 6:30 PM
Career development update / an example of an exciting project announced this month! bsky.app/profile/jmsc...