🧬 New pig models of neonatal #HCM show severe cardiac #hypertrophy and perinatal lethality from MYBPC3 and MYH7 mutations.
Pigs were highly sensitive to sarcomeric gene disruption, developing severe HCM, suggesting they may not be ideal genetic models.
🔗 www.sciencedirect.com/science/arti...

12-week-old #ob/ob mice show mild DCM with no major structural changes in #MAMs.
Proteins linked to lipid metabolism and stress response were increased in MAMs, while hypoxic stress triggered more cardiomyocyte death.

www.sciencedirect.com/science/arti...

Calling all #immunofluorescence scientists! Teng et al. showed glyoxal enhances IF signal and co-localisation while reducing staining artifacts, making it a superior alternative to PFA in murine cardiac tissue research.

www.sciencedirect.com/science/arti...

📈 Circulating adropin is linked to higher risk of #AKI in patients with acutely decompensated #heartfailure (#ADHF) after decongestive therapy.
It outperformed conventional biomarkers like urinary ACR and NT-proBNP.
#CardioRenal #Biomarkers

www.sciencedirect.com/science/arti...

Kazantzi et al show that #MEK–ERK1/2 and #PKC pathways independently and synergistically modulate ETB receptor upregulation under flow cessation. These signalling axes may be promising targets for #cerebrovascular disease.

Read more here! www.sciencedirect.com/science/arti...

NIH-funded and need to publish in an open-access journal? JMCC Plus is fully OA and we're offering a 50% APC discount until 30 Sept 2025! Submit your work and join our growing community of cardiovascular researchers. #OpenAccess #Cardiac #Research

www.sciencedirect.com/journal/jour...

New in JMCC Plus: This study presents a multidimensional analysis to investigate culture-induced alterations in living #myocardial slices, demonstrating structural integrity despite changes to slices’ functional and #molecular profiles

Read more here! www.sciencedirect.com/science/arti...

Exciting news! Clarivate has released the inaugural #ImpactFactor for 2024, and JMCC Plus, just 3 years since its launch, has earned a spot in Q2! A huge thank you to our authors, reviewers, and readers for helping us reach this milestone. #AcademicPublishing #JMCCPlus

Heart failure alters organelle dynamics. Latchman et al. reveal striking shifts in failing cardiomyocytes- more rounded #mitochondria, disrupted SR-mitochondria juxtaposition and altered lipid droplet size across #heart #failure types .
www.sciencedirect.com/science/arti...
‪@upenn.edu @temple.edu‬

The JMCC and JMCC Plus Reception is in full swing at #ISHR World Congress 2025! A great opportunity to bring our editorial team and reviewers together, while hearing from JMCC #EiC Rong Tian and JMCC Plus #EiC @davorpavlovic.bsky.social

The 25th World Congress of #ISHR 2025 in Nara, Japan, has officially begun with over 1000 members attending! A fantastic start to the conference, welcomed by traditional Japanese music, before hearing from this years' ISHR awardees.
@ishr-aus.bsky.social

A recent study found that women undergoing cardiac surgery show reduced CD39/CD73 expression and greater #fibrosis. Using a #CD39 mimetic and #CD73 enhancer improved cardiac function and reduced fibrosis in an ovariectomy + high-fat diet mouse model.

Read more: www.sciencedirect.com/science/arti...

Exciting news! Join us for another exclusive ISHR-ES webinar: The Beating Edge of Cardiac Metabolism! 🫀💡
📅 Friday, 7th March 2025 | ⏰ 14:00 to15:00 GMT + 1| 💻 Live Online

Hear from three leading experts as they dive into cutting-edge research & innovations.
🔗 Register now: https://buff.ly/4aWIbv1

New research by Grazide and colleagues has revealed a novel biomarker for myocardial infarction risk. Rubicon, a negative regulator of autophagy, could aid in the early detection of individuals at high risk for MI
Read more here: https://buff.ly/3WyWO1i

Wishing everyone Happy Holidays from the #JMCCPlus team!

2024 has been a great year for the journal, but wouldnt have been possible without the hard work of the editors, reviewers, authors and readers, so thanks!

Looking forward to what #2025 brings!

#CardioSky

We are pleased to have recently published the abstracts from both the ISHR_ES and ISHR-Southeast Asia meetings..

Interested in the latest work presented there? Check out the following links!

sciencedirect.com/journal/jour...

sciencedirect.com/journal/jour...

#CardioSky

In our December issue, fantastic research by Jiang et al. highlights how perivascular #fibrosis in intramyocardial blood vessels may play a key role in #myocardialinfarction (#MI) progression.

Read more here: www.sciencedirect.com/science/arti...

Congratulation to the authors on this great piece of work just published in our journal!

Learn more about it in the thread below from @dr-yktham.bsky.social