@jleven.bsky.social
What if the patient is hypokalemia due to RTA?
December 7, 2024 at 2:03 PM
What if the patient is hypokalemia due to RTA?
But it was mainly in those without dose adjustment and not linked to lactic acidosis. Interestingly, the metformin group had a lower risk of ESRD progression, although the reasons are unclear. www.thelancet.com/journals/lan...
Metformin use and mortality in patients with advanced chronic kidney disease: national, retrospective, observational, cohort study
Use of metformin in people with type 2 diabetes and a serum creatinine concentration
greater than 530 μmol/L is associated with a significantly increased risk of all-cause
mortality compared with non-...
www.thelancet.com
November 23, 2024 at 2:44 PM
But it was mainly in those without dose adjustment and not linked to lactic acidosis. Interestingly, the metformin group had a lower risk of ESRD progression, although the reasons are unclear. www.thelancet.com/journals/lan...
I think the significance is that metformin remains an effective diabetes medication whereas SGLT2i are considerably less effective in advanced CKD. There was a Taiwan retrospective registry study finding increased mortality in patients on metformin with advanced ckd
November 23, 2024 at 2:44 PM
I think the significance is that metformin remains an effective diabetes medication whereas SGLT2i are considerably less effective in advanced CKD. There was a Taiwan retrospective registry study finding increased mortality in patients on metformin with advanced ckd
The STEP study, used less than 130 as a treatment arm and showed similar benefits to SPRINT. However, the usual treatment arm allowed was less than 150.
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Trial of Intensive Blood-Pressure Control in Older Patients with Hypertension | NEJM
The appropriate target for systolic blood pressure to reduce cardiovascular risk in
older patients with hypertension remains unclear. In this multicenter, randomized,
controlled trial, we assigned ...
www.nejm.org
November 18, 2024 at 1:59 PM
The STEP study, used less than 130 as a treatment arm and showed similar benefits to SPRINT. However, the usual treatment arm allowed was less than 150.
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
May be easier to identify who “isn’t” a candidate
November 13, 2024 at 4:19 PM
May be easier to identify who “isn’t” a candidate