While over here discussions are about slashing Science funding, the Swiss are proposing to put it center stage on their currency. And I thought I was returning to the "Mecca of Science", not leaving it... 😅 Also, is this even real money? www.neuebanknotenserie.ch/detailview.h...

We evaluated combinatorial E-P modifications, finding a new role for the TATA box, which acts as a 'noise suppressor' to prevent expression from weak (1 TFBS) "enhancers". With increasing E strength it switches to activation thus expanding the dynamic range.

It also allows testing "out-of context" enhancer activities and what enhancer-native molecular features correlate with expression.

EXTRA-seq can be targeted to endogenous loci, allowing us to measure "near-native" gene expression as a function of dozens of newly introduced E-P genotypes (over 2kb apart).