Jiyeon Leem
@jiyeonleem.bsky.social
Postdoctoral researcher at Yale in the lab of Binyam Mogessie.
Reposted by Jiyeon Leem
Binyam Mogessie (@binyammogessie.bsky.social) and Jiyeon Leem (@jiyeonleem.bsky.social) from Yale MCDB reveal a new way to mimic egg aging in the lab, uncovering why chromosome errors rise with maternal age. 🧬✨
buff.ly/FMUoFhD
buff.ly/FMUoFhD
A new tool for understanding chromosome abnormalities in the eggs of older women
Yale researchers have created a new method for simulating “aging-like” chromosome errors in mouse eggs to better understand female reproductive lifespan.
buff.ly
November 11, 2025 at 3:05 PM
Binyam Mogessie (@binyammogessie.bsky.social) and Jiyeon Leem (@jiyeonleem.bsky.social) from Yale MCDB reveal a new way to mimic egg aging in the lab, uncovering why chromosome errors rise with maternal age. 🧬✨
buff.ly/FMUoFhD
buff.ly/FMUoFhD
Reposted by Jiyeon Leem
Online now! @binyammogessie.bsky.social, @jiyeonleem.bsky.social and colleagues provide a system that enables cohesion protein depletion in mouse oocytes, probing reproductive age-related egg aneuploidy.
doi.org/10.1038/s435...
doi.org/10.1038/s435...
A versatile cohesion manipulation system probes female reproductive age-related egg aneuploidy - Nature Aging
To study pathways that lead to aneuploidy during aging, the authors provide a system that enables cohesion protein depletion in mouse oocytes, mimicking effects that occur during aging. They uncover a...
doi.org
November 5, 2025 at 10:06 AM
Online now! @binyammogessie.bsky.social, @jiyeonleem.bsky.social and colleagues provide a system that enables cohesion protein depletion in mouse oocytes, probing reproductive age-related egg aneuploidy.
doi.org/10.1038/s435...
doi.org/10.1038/s435...
Reposted by Jiyeon Leem
We built a targeted protein degradation–based system to mimic reproductive age-related aneuploidy in young eggs - revealing how chromosome errors associated with female infertility arise with age. 🧬✨
With @jiyeonleem.bsky.social and our team at Yale MCDB.
Read: www.nature.com/articles/s43...
With @jiyeonleem.bsky.social and our team at Yale MCDB.
Read: www.nature.com/articles/s43...
A versatile cohesion manipulation system probes female reproductive age-related egg aneuploidy - Nature Aging
To study pathways that lead to aneuploidy during aging, the authors provide a system that enables cohesion protein depletion in mouse oocytes, mimicking effects that occur during aging. They uncover a...
www.nature.com
November 4, 2025 at 1:17 PM
We built a targeted protein degradation–based system to mimic reproductive age-related aneuploidy in young eggs - revealing how chromosome errors associated with female infertility arise with age. 🧬✨
With @jiyeonleem.bsky.social and our team at Yale MCDB.
Read: www.nature.com/articles/s43...
With @jiyeonleem.bsky.social and our team at Yale MCDB.
Read: www.nature.com/articles/s43...
Reposted by Jiyeon Leem
Jiyeon Leem (Mogessie Lab) has been awarded a Fellowship from the Lalor Foundation for pursuing her research project ‘Uncovering the origins of egg aneuploidy associated with female reproductive aging’. Congratulations, Jiyeon!
May 27, 2025 at 9:52 PM
Jiyeon Leem (Mogessie Lab) has been awarded a Fellowship from the Lalor Foundation for pursuing her research project ‘Uncovering the origins of egg aneuploidy associated with female reproductive aging’. Congratulations, Jiyeon!
Reposted by Jiyeon Leem
Some good news during these difficult times. Please check out our new preprint. We built a new tool to probe the origins of high oocyte aneuploidy rates at advanced female reproductive ages. This NIH funded work was led by a fantastic postdoc in the lab, Jiyeon Leem. www.biorxiv.org/content/10.1...
A versatile cohesion manipulation system reveals CENP-A dysfunction accelerates female reproductive age-related egg aneuploidy.
Female reproductive aging is accompanied by a dramatic rise in the incidence of egg aneuploidy. Premature loss of chromosome cohesion proteins and untimely separation of chromosomes is thought to unde...
www.biorxiv.org
February 28, 2025 at 12:39 PM
Some good news during these difficult times. Please check out our new preprint. We built a new tool to probe the origins of high oocyte aneuploidy rates at advanced female reproductive ages. This NIH funded work was led by a fantastic postdoc in the lab, Jiyeon Leem. www.biorxiv.org/content/10.1...