Jiyeon Leem
jiyeonleem.bsky.social
Jiyeon Leem
@jiyeonleem.bsky.social
Postdoctoral researcher at Yale in the lab of Binyam Mogessie.
Reposted by Jiyeon Leem
Binyam Mogessie (@binyammogessie.bsky.social) and Jiyeon Leem (@jiyeonleem.bsky.social) from Yale MCDB reveal a new way to mimic egg aging in the lab, uncovering why chromosome errors rise with maternal age. 🧬✨

buff.ly/FMUoFhD
A new tool for understanding chromosome abnormalities in the eggs of older women
Yale researchers have created a new method for simulating “aging-like” chromosome errors in mouse eggs to better understand female reproductive lifespan.
buff.ly
November 11, 2025 at 3:05 PM
Reposted by Jiyeon Leem
Online now! @binyammogessie.bsky.social, @jiyeonleem.bsky.social and colleagues provide a system that enables cohesion protein depletion in mouse oocytes, probing reproductive age-related egg aneuploidy.
doi.org/10.1038/s435...
A versatile cohesion manipulation system probes female reproductive age-related egg aneuploidy - Nature Aging
To study pathways that lead to aneuploidy during aging, the authors provide a system that enables cohesion protein depletion in mouse oocytes, mimicking effects that occur during aging. They uncover a...
doi.org
November 5, 2025 at 10:06 AM
Reposted by Jiyeon Leem
We built a targeted protein degradation–based system to mimic reproductive age-related aneuploidy in young eggs - revealing how chromosome errors associated with female infertility arise with age. 🧬✨
With @jiyeonleem.bsky.social and our team at Yale MCDB.

Read: www.nature.com/articles/s43...
A versatile cohesion manipulation system probes female reproductive age-related egg aneuploidy - Nature Aging
To study pathways that lead to aneuploidy during aging, the authors provide a system that enables cohesion protein depletion in mouse oocytes, mimicking effects that occur during aging. They uncover a...
www.nature.com
November 4, 2025 at 1:17 PM
Reposted by Jiyeon Leem
Jiyeon Leem (Mogessie Lab) has been awarded a Fellowship from the Lalor Foundation for pursuing her research project ‘Uncovering the origins of egg aneuploidy associated with female reproductive aging’. Congratulations, Jiyeon!
May 27, 2025 at 9:52 PM
Reposted by Jiyeon Leem
Some good news during these difficult times. Please check out our new preprint. We built a new tool to probe the origins of high oocyte aneuploidy rates at advanced female reproductive ages. This NIH funded work was led by a fantastic postdoc in the lab, Jiyeon Leem. www.biorxiv.org/content/10.1...
A versatile cohesion manipulation system reveals CENP-A dysfunction accelerates female reproductive age-related egg aneuploidy.
Female reproductive aging is accompanied by a dramatic rise in the incidence of egg aneuploidy. Premature loss of chromosome cohesion proteins and untimely separation of chromosomes is thought to unde...
www.biorxiv.org
February 28, 2025 at 12:39 PM