Jim Notwell
@jimnotwell.bsky.social
Computational {biology, chemistry} @MapLightRx. Long-term collaborator of @ellenrim.bsky.social
Reposted by Jim Notwell
Really excited to join Stanford ChemE this September! We'll engineer proteins in plant immune and hormone pathways, combining high-throughput directed evolution with ML. Our goal is to enhance climate stress resilience and disease resistance in crops: rim.stanford.edu
Harnessing synthetic biology to engineer resilient crops
rim.stanford.edu
August 20, 2025 at 4:37 PM
Really excited to join Stanford ChemE this September! We'll engineer proteins in plant immune and hormone pathways, combining high-throughput directed evolution with ML. Our goal is to enhance climate stress resilience and disease resistance in crops: rim.stanford.edu
Reposted by Jim Notwell
Reposted by Jim Notwell
The Internet Archive has to date downloaded 500 terabytes of US government websites, which it crawls at the end of every presidential term. The whole archive is fully searchable. This effort's housed by a donation-funded nonprofit, not a branch of the US government. blog.archive.org/2024/05/08/e...
End of Term Web Archive – Preserving the Transition of a Nation | Internet Archive Blogs
blog.archive.org
February 1, 2025 at 12:58 AM
The Internet Archive has to date downloaded 500 terabytes of US government websites, which it crawls at the end of every presidential term. The whole archive is fully searchable. This effort's housed by a donation-funded nonprofit, not a branch of the US government. blog.archive.org/2024/05/08/e...
Reposted by Jim Notwell
I'm very excited to share my first graduate research project! Check out our preprint which describes how data generated with directed evolution can be used to model the phenotypic effects of naturally-evolved sequence variants. (1/11) www.biorxiv.org/content/10.1...
Combining Directed Evolution with Machine Learning Enables Accurate Genotype-to-Phenotype Predictions
Linking sequence variation to phenotypic effects is critical for efficient exploitation of large genomic datasets. Here we present a novel approach combining directed evolution with protein language m...
www.biorxiv.org
January 29, 2025 at 10:23 PM
I'm very excited to share my first graduate research project! Check out our preprint which describes how data generated with directed evolution can be used to model the phenotypic effects of naturally-evolved sequence variants. (1/11) www.biorxiv.org/content/10.1...
Reposted by Jim Notwell
FYI the designed esmGFP is 58% identical to the most similar extant GFP sequence - hence "500 million years of evolution" - but nearly half of the novelty (the 42% unaligned part of the seq) is derived from one other protein. Originally caught by @btnaughton.bsky.social, source link in alt text
January 18, 2025 at 6:42 AM
FYI the designed esmGFP is 58% identical to the most similar extant GFP sequence - hence "500 million years of evolution" - but nearly half of the novelty (the 42% unaligned part of the seq) is derived from one other protein. Originally caught by @btnaughton.bsky.social, source link in alt text
Reposted by Jim Notwell
I think you're describing science, IMO. Everything is atop a foundation of basic research. An example: at a previous company, I worked on a series of small-molecule inhibitors of Hormone-Sensitive Lipase, a possible target for Type II diabetes and related conditions. (1/10)
January 5, 2025 at 10:04 PM
I think you're describing science, IMO. Everything is atop a foundation of basic research. An example: at a previous company, I worked on a series of small-molecule inhibitors of Hormone-Sensitive Lipase, a possible target for Type II diabetes and related conditions. (1/10)
Reposted by Jim Notwell
I shared this story about Jimmy Carter on X last year. I'd like to put it here, too.
It starts with a reporter's keepsake.
These are the notes President Carter handed me after I met him at a $MRK event to celebrate the company's collaboration with the Carter Center to end river blindness. 1/8
It starts with a reporter's keepsake.
These are the notes President Carter handed me after I met him at a $MRK event to celebrate the company's collaboration with the Carter Center to end river blindness. 1/8
December 30, 2024 at 12:51 AM
I shared this story about Jimmy Carter on X last year. I'd like to put it here, too.
It starts with a reporter's keepsake.
These are the notes President Carter handed me after I met him at a $MRK event to celebrate the company's collaboration with the Carter Center to end river blindness. 1/8
It starts with a reporter's keepsake.
These are the notes President Carter handed me after I met him at a $MRK event to celebrate the company's collaboration with the Carter Center to end river blindness. 1/8