@jimenascoccia.bsky.social
Reposted
There are very little methods to control reactivity of bioorthogonal reaction of tetrazines with alkenes/alkynes. We proved rotaxanation slows kinetics, and disassembly of mechanical bond activates the reaction. @ipna.csic.es
@angewandtechemie.bsky.social
onlinelibrary.wiley.com/doi/10.1002/...
@angewandtechemie.bsky.social
onlinelibrary.wiley.com/doi/10.1002/...
Control of Tetrazine Bioorthogonal Reactivity by Rotaxanation
Control of tetrazine-mediated inverse electron demand Diels–Alder (IEDDA) reaction has been achieved by rotaxanation. Tetrazine rotaxanes were synthesized in high yield and they displayed a much slow...
onlinelibrary.wiley.com
September 22, 2025 at 8:15 AM
There are very little methods to control reactivity of bioorthogonal reaction of tetrazines with alkenes/alkynes. We proved rotaxanation slows kinetics, and disassembly of mechanical bond activates the reaction. @ipna.csic.es
@angewandtechemie.bsky.social
onlinelibrary.wiley.com/doi/10.1002/...
@angewandtechemie.bsky.social
onlinelibrary.wiley.com/doi/10.1002/...