Jillian Lau
@jillianlau.bsky.social
Clinician researcher in Melbourne 🇦🇺🐨
All about HIV cure
NHMRC EL1 Fellow
All about HIV cure
NHMRC EL1 Fellow
More on the reservoir. The AGING cohort in Argentina (defined as 50 or older!!!) looked at total DNA and pro-inflammatory cytokine profiles longitudinally over 1 year.
No changes but a short follow up time. I’d be interested in following this cohort over time w longer follow up analyses
#IAS2025
No changes but a short follow up time. I’d be interested in following this cohort over time w longer follow up analyses
#IAS2025
July 17, 2025 at 1:47 PM
More on the reservoir. The AGING cohort in Argentina (defined as 50 or older!!!) looked at total DNA and pro-inflammatory cytokine profiles longitudinally over 1 year.
No changes but a short follow up time. I’d be interested in following this cohort over time w longer follow up analyses
#IAS2025
No changes but a short follow up time. I’d be interested in following this cohort over time w longer follow up analyses
#IAS2025
This #IAS2025 poster looked at the #HIV reservoir in the Rakai cohort Uganda, measured w QVOA. As we know, QVOA < total HIV DNA.
Interestingly QVOA doubled over 5 years for women in the cohort pre- and post-menopause.
More evidence that female sex hormones impact reservoir. IPDA data coming
Interestingly QVOA doubled over 5 years for women in the cohort pre- and post-menopause.
More evidence that female sex hormones impact reservoir. IPDA data coming
July 17, 2025 at 1:42 PM
Always an excellent and engaging speaker Katie Bar, #IAS2025 Track A rapporteur summarises 3 days packed with science in 14 minutes.
What an amazing job! Check out the recording for a really nice overview of the basic sciences presented here in Kigali
What an amazing job! Check out the recording for a really nice overview of the basic sciences presented here in Kigali
July 17, 2025 at 1:31 PM
Always an excellent and engaging speaker Katie Bar, #IAS2025 Track A rapporteur summarises 3 days packed with science in 14 minutes.
What an amazing job! Check out the recording for a really nice overview of the basic sciences presented here in Kigali
What an amazing job! Check out the recording for a really nice overview of the basic sciences presented here in Kigali
Qualitative interviews and quantitative surveys on mental health, decision making certainty, self esteem and resilience were performed at multiple timepoints on the FRESH cohort participants.
The investigators stress the importance of conducting mental health assessments throughout these trials
The investigators stress the importance of conducting mental health assessments throughout these trials
July 17, 2025 at 1:26 PM
Qualitative interviews and quantitative surveys on mental health, decision making certainty, self esteem and resilience were performed at multiple timepoints on the FRESH cohort participants.
The investigators stress the importance of conducting mental health assessments throughout these trials
The investigators stress the importance of conducting mental health assessments throughout these trials
#HIVcure in the poster hall at #IAS2035 on Thursday!
Social & behavioural research done as part of FRESH cohort #ATI study in Africa. So important to include this work w the biomedical analysis.
Family & partners of study participants underwent in-depth interviews - concerns raised abt risks
Social & behavioural research done as part of FRESH cohort #ATI study in Africa. So important to include this work w the biomedical analysis.
Family & partners of study participants underwent in-depth interviews - concerns raised abt risks
July 17, 2025 at 11:37 AM
Modified IPDA (because of the lentiviral vector) demonstrated sustained reduction in intact provirus even if plasma viral load increased and necessitated restart ART
July 17, 2025 at 11:04 AM
Modified IPDA (because of the lentiviral vector) demonstrated sustained reduction in intact provirus even if plasma viral load increased and necessitated restart ART
Rebound virus from participants of the PULSE study #ATI was sequences and IMAP peptides are found in 90-100%
Their peptide pool able to trigger immune responses in transient virus controllers, response varies between donors
Their peptide pool able to trigger immune responses in transient virus controllers, response varies between donors
July 17, 2025 at 10:43 AM
Rebound virus from participants of the PULSE study #ATI was sequences and IMAP peptides are found in 90-100%
Their peptide pool able to trigger immune responses in transient virus controllers, response varies between donors
Their peptide pool able to trigger immune responses in transient virus controllers, response varies between donors
More from @westmeadinst.bsky.social at #IAS2025 at the cutting edge Basic Science session
Josefina Marin presents on IMAP (immunoinformatic analysis pipeline) which selects peptides found within >85% Los Alamos database) - known as IMAP peptides.
Josefina Marin presents on IMAP (immunoinformatic analysis pipeline) which selects peptides found within >85% Los Alamos database) - known as IMAP peptides.
July 17, 2025 at 10:43 AM
More from @westmeadinst.bsky.social at #IAS2025 at the cutting edge Basic Science session
Josefina Marin presents on IMAP (immunoinformatic analysis pipeline) which selects peptides found within >85% Los Alamos database) - known as IMAP peptides.
Josefina Marin presents on IMAP (immunoinformatic analysis pipeline) which selects peptides found within >85% Los Alamos database) - known as IMAP peptides.
A really nice summary of where CAR-T cell therapy in #HIVcure is at.
Briefly - promising but a while to go to address issues including lack of HIV antigens in PLWH on ART
I’ll be coming back to relisten to this talk!
Briefly - promising but a while to go to address issues including lack of HIV antigens in PLWH on ART
I’ll be coming back to relisten to this talk!
July 17, 2025 at 9:31 AM
A really nice summary of where CAR-T cell therapy in #HIVcure is at.
Briefly - promising but a while to go to address issues including lack of HIV antigens in PLWH on ART
I’ll be coming back to relisten to this talk!
Briefly - promising but a while to go to address issues including lack of HIV antigens in PLWH on ART
I’ll be coming back to relisten to this talk!
Several strategies explored to improve CAR-T cell activity in HIV
July 17, 2025 at 9:31 AM
Several strategies explored to improve CAR-T cell activity in HIV
N=32 majority female
16 reviewed by safety monitoring committee and 2/3 had experienced viral rebound by week 12.
Possibly indicating subtype C virus not sensitive to the bNAbs?
Study stopped enrolment as per pre-specified criteria. Further virology immunology and reservoir data to follow
16 reviewed by safety monitoring committee and 2/3 had experienced viral rebound by week 12.
Possibly indicating subtype C virus not sensitive to the bNAbs?
Study stopped enrolment as per pre-specified criteria. Further virology immunology and reservoir data to follow
July 17, 2025 at 9:08 AM
N=32 majority female
16 reviewed by safety monitoring committee and 2/3 had experienced viral rebound by week 12.
Possibly indicating subtype C virus not sensitive to the bNAbs?
Study stopped enrolment as per pre-specified criteria. Further virology immunology and reservoir data to follow
16 reviewed by safety monitoring committee and 2/3 had experienced viral rebound by week 12.
Possibly indicating subtype C virus not sensitive to the bNAbs?
Study stopped enrolment as per pre-specified criteria. Further virology immunology and reservoir data to follow
Another #HIVcure #ATI study from Southern Africa: PAUSE study a 3bnc117 & 101074 LS-J versions.
bNAb screening NOT conducted pre-enrolment
Primary endpoint again is viral rebound at 24w when therapeutic bNAb levels are still circulating - like RIO & Marina Caskey’s bNAb study presented yesterday
bNAb screening NOT conducted pre-enrolment
Primary endpoint again is viral rebound at 24w when therapeutic bNAb levels are still circulating - like RIO & Marina Caskey’s bNAb study presented yesterday
July 17, 2025 at 9:08 AM
In the immunological control for #HIVcure session at #IAS2025, my friend @jespergunst.bsky.social presents beautifully about what we know & what we don’t know about predictors of post treatment control & post intervention control with a shout out to the HIV reservoirs consortium.
July 17, 2025 at 8:59 AM
In the immunological control for #HIVcure session at #IAS2025, my friend @jespergunst.bsky.social presents beautifully about what we know & what we don’t know about predictors of post treatment control & post intervention control with a shout out to the HIV reservoirs consortium.
Whoops what did I do to my photo???
Here is the poster
Here is the poster
July 16, 2025 at 9:05 PM
Whoops what did I do to my photo???
Here is the poster
Here is the poster
Study from Aus 🇦🇺🐨🦘 in the poster hall #IAS2025
Our friends at @westmeadinst.bsky.social looked at cells from blood & pleural effusion fluid from people w HIV w active pleural TB.
TB coinfection impairs HIV specific CD8 T cells causing more genetically intact provirus in pleural effusion cells.
Our friends at @westmeadinst.bsky.social looked at cells from blood & pleural effusion fluid from people w HIV w active pleural TB.
TB coinfection impairs HIV specific CD8 T cells causing more genetically intact provirus in pleural effusion cells.
July 16, 2025 at 8:59 PM
Study from Aus 🇦🇺🐨🦘 in the poster hall #IAS2025
Our friends at @westmeadinst.bsky.social looked at cells from blood & pleural effusion fluid from people w HIV w active pleural TB.
TB coinfection impairs HIV specific CD8 T cells causing more genetically intact provirus in pleural effusion cells.
Our friends at @westmeadinst.bsky.social looked at cells from blood & pleural effusion fluid from people w HIV w active pleural TB.
TB coinfection impairs HIV specific CD8 T cells causing more genetically intact provirus in pleural effusion cells.
#HIVcure in the poster hall at #IAS2025 on Wednesday
This poster from Duke Transplant Centre highlights the HOPE Act in USA: 500 transplants in PLWH receiving organ transplants from HIV+ donors.
This is a rich opportunity to biobank discarded lymphoid tissue from the operation for research
This poster from Duke Transplant Centre highlights the HOPE Act in USA: 500 transplants in PLWH receiving organ transplants from HIV+ donors.
This is a rich opportunity to biobank discarded lymphoid tissue from the operation for research
July 16, 2025 at 3:33 PM
Gus Valen in the innovative virology section - from DIPS to TIPS.
His team engineered a therapeutic from a natural process that causes viral load vascilations in plasma.
Tested in monkey model - single dose TIPS led to lower viral set point.
Track A #IAS2025
His team engineered a therapeutic from a natural process that causes viral load vascilations in plasma.
Tested in monkey model - single dose TIPS led to lower viral set point.
Track A #IAS2025
July 15, 2025 at 2:43 PM
Gus Valen in the innovative virology section - from DIPS to TIPS.
His team engineered a therapeutic from a natural process that causes viral load vascilations in plasma.
Tested in monkey model - single dose TIPS led to lower viral set point.
Track A #IAS2025
His team engineered a therapeutic from a natural process that causes viral load vascilations in plasma.
Tested in monkey model - single dose TIPS led to lower viral set point.
Track A #IAS2025
Joseph Eron - LEN plus 3bnc117 and 101074 (bought by Gilead and now “TAB and ZAB”).
I think this was a TREATMENT study. 6 monthly dosing of LEN TAB and ZAB. 3 virological failures (but Joseph using the wording of viral rebound as if the participants underwent treatment interruption).
I think this was a TREATMENT study. 6 monthly dosing of LEN TAB and ZAB. 3 virological failures (but Joseph using the wording of viral rebound as if the participants underwent treatment interruption).
July 15, 2025 at 1:50 PM
Joseph Eron - LEN plus 3bnc117 and 101074 (bought by Gilead and now “TAB and ZAB”).
I think this was a TREATMENT study. 6 monthly dosing of LEN TAB and ZAB. 3 virological failures (but Joseph using the wording of viral rebound as if the participants underwent treatment interruption).
I think this was a TREATMENT study. 6 monthly dosing of LEN TAB and ZAB. 3 virological failures (but Joseph using the wording of viral rebound as if the participants underwent treatment interruption).