Jiliang Zhou
@jiliang-zhou.bsky.social
Fan of smooth muscle, Barce FC & dog
This case suggests that MYH11 patients may have a similar angiographic and brain parenchymal phenotype to patients with ACTA2 mutations👍
September 27, 2025 at 6:16 PM
This case suggests that MYH11 patients may have a similar angiographic and brain parenchymal phenotype to patients with ACTA2 mutations👍
Interesting! MYH11 mutation in humans should have similar occlusive artery manifestations?
September 26, 2025 at 10:46 PM
Interesting! MYH11 mutation in humans should have similar occlusive artery manifestations?
Interesting. Will read 👍
September 22, 2025 at 10:38 PM
Interesting. Will read 👍
One more interesting thing I noticed is that the technique using AAV9-SM22α-shX or AAV9-SM22a-gene for in vivo knockdown or over expression specifically in SMCs is almost exclusively from labs in China. We might need to validate this in vivo delivery tool
July 13, 2025 at 9:57 PM
One more interesting thing I noticed is that the technique using AAV9-SM22α-shX or AAV9-SM22a-gene for in vivo knockdown or over expression specifically in SMCs is almost exclusively from labs in China. We might need to validate this in vivo delivery tool
“ATF3 Deficiency Exacerbates Ageing-Induced Atherosclerosis and Clinical Intervention Strategy”
The title is very odd to me. FYI: Nick Leeper has an ATF3 paper in Cardiovascular Research
The title is very odd to me. FYI: Nick Leeper has an ATF3 paper in Cardiovascular Research
July 12, 2025 at 6:11 PM
“ATF3 Deficiency Exacerbates Ageing-Induced Atherosclerosis and Clinical Intervention Strategy”
The title is very odd to me. FYI: Nick Leeper has an ATF3 paper in Cardiovascular Research
The title is very odd to me. FYI: Nick Leeper has an ATF3 paper in Cardiovascular Research
Soon will be on your bed😂
July 4, 2025 at 3:10 PM
Soon will be on your bed😂
Actually mir15/16 can inhibit YAP1, thereby reducing cell proliferation. Not sure whether YAP1 is upregulated in MiR 15/16 KO and is functionally involved in these settings as a down-stream target of miR15/16. Check out our publication in ATVB.
www.ahajournals.org/doi/10.1161/...
www.ahajournals.org/doi/10.1161/...
MicroRNA-15b/16 Attenuates Vascular Neointima Formation by Promoting the Contractile Phenotype of Vascular Smooth Muscle Through Targeting YAP | Arteriosclerosis, Thrombosis, and Vascular Biology
Objective—To investigate the functional role of the microRNA (miR)-15b/16 in vascular smooth
muscle (SM) phenotypic modulation. Approach and Results—We found that miR-15b/16 is one of the most abundan...
www.ahajournals.org
June 19, 2025 at 3:36 AM
Actually mir15/16 can inhibit YAP1, thereby reducing cell proliferation. Not sure whether YAP1 is upregulated in MiR 15/16 KO and is functionally involved in these settings as a down-stream target of miR15/16. Check out our publication in ATVB.
www.ahajournals.org/doi/10.1161/...
www.ahajournals.org/doi/10.1161/...
It seems odd but Dr. Xiaohong Lu at the dept has 2 NASA funded projects working on space medicine 😀
May 3, 2025 at 12:41 AM
It seems odd but Dr. Xiaohong Lu at the dept has 2 NASA funded projects working on space medicine 😀
Thanks for re-posting 💪
May 3, 2025 at 12:07 AM
Thanks for re-posting 💪
Not sure I am a guru on #SmoothMuscleCell😀
May 2, 2025 at 11:28 PM
Not sure I am a guru on #SmoothMuscleCell😀
Thanks for your visit and introducing bluesky😍 learned a great deal from you!
May 2, 2025 at 10:35 PM
Thanks for your visit and introducing bluesky😍 learned a great deal from you!